Trans-Sphenoidal Microsurgery in the Management of Non-Pituitary Tumours of the Sella Turcica

Pituitary tumours observations on large tumours which have spread widely beyond the confines of the sella turcica

British Journal of Surgery ◽

10.1002/bjs.18003915303 ◽

1951 ◽

Vol 39 (153) ◽

pp. 7-24 ◽

Cited By ~ 18

Author(s):

Hugh C. Trumble

Keyword(s):

Sella Turcica ◽

Pituitary Tumours

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Treatment of Aggressive Pituitary Adenomas and Carcinomas – An Overview

European Neurological Review ◽

10.17925/enr.2012.07.03.178 ◽

2012 ◽

Vol 7 (3) ◽

pp. 178

Author(s):

Luis V Syro ◽

Leon D Ortiz ◽

Fabio Rotondo ◽

Humberto Uribe ◽

Luis C Penagos ◽

...

Keyword(s):

Growth Rate ◽

Side Effects ◽

Pituitary Adenomas ◽

Treatment Options ◽

Sella Turcica ◽

Incomplete Resection ◽

Pituitary Tumours ◽

Non Invasive ◽

Rapid Growth Rate ◽

Pituitary Carcinomas

Most pituitary tumours are non-invasive, benign adenomas that remain confined to the sella turcica. Some of them recur, have a rapid growth rate, and invade surrounding tissues. These adenomas, considered aggressive pituitary tumours, are difficult to manage and present problems due to incomplete resection. A pituitary carcinoma is diagnosed when craniospinal and/or systemic metastases are documented. Treatment options for pituitary adenomas are surgery, radiation and drugs. Recent publications report the efficacy of temozolomide in the treatment of aggressive pituitary adenomas and carcinomas. Indications for, results with, and side effects of temozolomide therapy in aggressive pituitary tumours and pituitary carcinomas are reviewed here. Alternative treatment options for resistant or recurrent pituitary tumours are also discussed.

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The Ultrastructure of Lymphocytic Hypophysitis

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100098824 ◽

1981 ◽

Vol 39 ◽

pp. 466-467

Author(s):

S.L. Asa ◽

K. Kovacs ◽

J. M. Bilbao ◽

R. G. Josse ◽

K. Kreines

Keyword(s):

Electron Microscopy ◽

Plasma Cells ◽

Secretory Granules ◽

Sella Turcica ◽

Uranyl Acetate ◽

Lymphocytic Hypophysitis ◽

Pituitary Cells ◽

Transmission Electron ◽

Ultrathin Sections ◽

Mass Lesions

Seven cases of lymphocytic hypophysitis in women have been reported previously in association with various degrees of hypopituitarism. We report two pregnant patients who presented with mass lesions of the sella turcica, clinically mimicking pituitary adenoma. However, pathologic examination revealed extensive infiltration of the anterior pituitary by lymphocytes and plasma cells with destruction of the gland. To our knowledge, the ultrastructural features of lymphocytic hypophysitis have not been studied so far.For transmission electron microscopy, tissue from surgical specimens was fixed in glutaraldehyde, postfixed in OsO4, dehydrated and embedded in epoxy-resin. Ultrathin sections were stained with uranyl acetate and lead citrate and examined with a Philips 300 electron microscope.Electron microscopy revealed adenohypophysial cells of all types exhibiting varying degrees of injury. In the areas of most dense inflammatory cell infiltration pituitary cells contained large lysosomal bodies fusing with secretory granules (Fig. 1), as well as increased numbers of swollen mitochondria, indicating oncocytic transformation (Fig. 2).

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