Vesicular Carriers for Transcutaneous Immunization

2016 ◽  
pp. 319-335
Author(s):  
Udita Agrawal ◽  
Madhu Gupta ◽  
Suresh P. Vyas
Keyword(s):  
Vesicular Carriers ◽  
Transcutaneous Immunization

Emerging Role of Vesicular Carriers for Therapy of Visceral Leishmaniasis: Conventional versus Novel

2010 ◽  
Vol 27 (6) ◽  
pp. 461-507 ◽  
Author(s):  
Navneet Kumar ◽  
Swati Gupta ◽  
Anuradha Dube ◽  
Suresh P. Vyas
Keyword(s):  
Visceral Leishmaniasis ◽  
Vesicular Carriers

A Review of Transdermal Drug Delivery Using Nano-Vesicular Carriers: Transfersomes

2012 ◽  
Vol 2 (2) ◽  
pp. 164-171 ◽  
Author(s):  
Ishan Ghai ◽  
Hema Chaudhary ◽  
Shashank Ghai ◽  
Kanchan Kohli ◽  
Vikash Kr
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Vesicular Carriers

scholarly journals Transcutaneous Immunization Studies in Mice Using Diphtheria Toxoid-Loaded Vesicle Formulations and a Microneedle Array

2010 ◽  
Vol 28 (1) ◽  
pp. 145-158 ◽  
Author(s):  
Zhi Ding ◽  
Suzanne M. Bal ◽  
Stefan Romeijn ◽  
Gideon F. A. Kersten ◽  
Wim Jiskoot ◽  
...  
Keyword(s):  
Diphtheria Toxoid ◽  
Microneedle Array ◽  
Transcutaneous Immunization

Elegant flexible vesicular nanocarriers for the efficient skin delivery of topically applied drugs-

2021 ◽  
Vol 18 ◽  
Author(s):  
Waleed Albalawi ◽  
Surur Alharbi ◽  
Fahad Alanazi ◽  
Hameed Alahmadi ◽  
Mothib Alghamdi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Skin Diseases ◽  
Fungal Infections ◽  
Skin Barrier ◽  
Therapeutic Outcome ◽  
Health Concern ◽  
Inflammatory Skin Diseases ◽  
Skin Delivery ◽  
Pubmed Database ◽  
Vesicular Carriers

Background: Skin diseases represent a major health concern worldwide and negatively impact patients’ quality of life. Despite the availability of various efficacious drugs, their therapeutic outcome is often limited due to shortcomings related to the formidable skin barrier and unfavorable physicochemical properties of drugs. Flexible nano-vesicles have shown tremendous potential to overcome these hurdles and improve the local therapeutic effect of these drugs. Objective: This review article is aimed to shed light on flexible nano-vesicular carriers as a means to combat skin diseases. Methods: The literature was reviewed using PubMed database using various keywords such as liposomes, flexible (deformable liposomes) (transferosomes), ethosomes, transethosomes, niosomes, and spanlastics. Results: Liposomes and niosomes were found effective for the loading and release of both hydrophilic and lipophilic drugs. However, their limited skin penetration led to drug delivery to the outermost layers of skin only. This necessitates the search for innovative vesicular carriers, including liposomes, flexible (deformable liposomes), ethosomes, transethosomes, and spanlastics. These flexible nano-vesicular carriers showed enhanced drug delivery and deposition across various skin layers, which was better than their corresponding conventional vesicles. This resulted in superior drug efficacy against various skin diseases such as skin cancer, inflammatory skin diseases, superficial fungal infections, etc. Conclusion: Flexible nano-vesicular carriers have proven themselves as efficient drug delivery systems that are able to deliver their cargo into the deep skin layers and thus, improve the therapeutic outcome of various skin diseases. However, there remain some challenges that need to be addressed before these nanocarriers can be translated from the lab to clinics.

Active immunization using hand-push emulsification method increases the operator's risk of transcutaneous immunization

2018 ◽  
Vol 506 (4) ◽  
pp. 970-975
Author(s):  
Xiaochen Yin ◽  
Suli Zhang ◽  
Zhen Zhou ◽  
Jingwei Bian ◽  
Ye Wu ◽  
...  
Keyword(s):  
Active Immunization ◽  
Transcutaneous Immunization

scholarly journals Proteomic Profiling of Mammalian COPII Vesicles

2018 ◽  
Author(s):  
Frank Adolf ◽  
Manuel Rhiel ◽  
Bernd Hessling ◽  
Andrea Hellwig ◽  
Felix T. Wieland
Keyword(s):  
Intracellular Transport ◽  
Spectrometric Analysis ◽  
Secretory Proteins ◽  
Proteomic Profiling ◽  
Vesicular Carriers ◽  
Copii Vesicle ◽  
Cargo Proteins ◽  
Core Proteome ◽  
Copii Vesicles

AbstractIntracellular transport and homeostasis of the endomembrane system in eukaryotic cells depend on formation and fusion of vesicular carriers. COPII vesicles export newly synthesized secretory proteins from the endoplasmic reticulum (ER). They are formed by sequential recruitment of the small GTP binding protein Sar1, the inner coat complex Sec23/24, and the outer coat complex Sec13/31. In order to investigate the roles of mammalian Sec24 isoforms in cargo sorting, we have combined in vitro COPII vesicle reconstitutions with SILAC-based mass spectrometric analysis. This approach enabled us to identify the core proteome of mammalian COPII vesicles. Comparison of the proteomes generated from vesicles with different Sec24 isoforms confirms several established isoform-dependent cargo proteins, and identifies ERGIC1 and CNIH1 as novel Sec24C‐ and Sec24A-specific cargo proteins, respectively. Proteomic analysis of vesicles reconstituted with a Sec24C mutant, bearing a compromised binding site for the ER-to-Golgi QSNARE Syntaxin5, revealed that the SM/Munc18 protein SCFD1 binds to Syntaxin5 prior to its sorting into COPII vesicles. Furthermore, analysis of Sec24D mutants implicated in the development of a syndromic form of osteogenesis imperfecta showed sorting defects for the three ER-to-Golgi QSNAREs Syntaxin5, GS27, and Bet1.

scholarly journals Viruses as vesicular carriers of the viral genome: A functional module perspective

2010 ◽  
Vol 1803 (4) ◽  
pp. 507-519 ◽  
Author(s):  
Bastian Thaa ◽  
Klaus Peter Hofmann ◽  
Michael Veit
Keyword(s):  
Viral Genome ◽  
Functional Module ◽  
Vesicular Carriers
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