Ultradeformable Vesicles as Skin Drug Delivery Systems: Mechanisms of Action

2016 ◽  
pp. 137-145 ◽  
Author(s):  
Gamal M. El Maghraby
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Mechanisms Of Action ◽  
Delivery Systems

scholarly journals The main potentialities of resveratrol for drug delivery systems

2015 ◽  
Vol 51 (3) ◽  
pp. 499-513 ◽  
Author(s):  
Joana Ruivo ◽  
Cátia Francisco ◽  
Rita Oliveira ◽  
Ana Figueiras
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Physicochemical Properties ◽  
Drug Delivery Systems ◽  
Mechanisms Of Action ◽  
Delivery Systems ◽  
Therapeutic Applications ◽  
Natural Polyphenol ◽  
Prevention And Therapy ◽  
Novel Therapeutic

Resveratrol (RSV), a natural polyphenol found in grapes, was found to be effective in the prevention and therapy of several diseases, however, it does have unfavourable physicochemical properties. In this context, an increasing number of studies have aimed at developing novel therapeutic systems for its delivery to overcome these disadvantages. This review focuses on the mechanisms of action and therapeutic applications. Finally, it also describes some tested formulations for RSV administration, controlled release and targeting, developed with the purpose of increasing RSV bioavailability.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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