Opposite lipid signaling pathways tightly control proline accumulation in Arabidopsis thaliana and Thellungiella halophila

2008 ◽  
pp. 317-324 ◽  
Author(s):  
Mohamed Ali Ghars ◽  
Elodie Parre ◽  
Anne-Sophie Leprince ◽  
Marianne Bordenave ◽  
Delphine Lefebvre-De Vos ◽  
...  
Keyword(s):  
Arabidopsis Thaliana ◽  
Signaling Pathways ◽  
Proline Accumulation ◽  
Lipid Signaling ◽  
Thellungiella Halophila

The Role of Lipids and Membranes in the Pathogenesis of Alzheimer's Disease: A Comprehensive View

2018 ◽  
Vol 15 (13) ◽  
pp. 1191-1212 ◽  
Author(s):  
Botond Penke ◽  
Gábor Paragi ◽  
János Gera ◽  
Róbert Berkecz ◽  
Zsolt Kovács ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Signaling Pathways ◽  
Membrane Lipids ◽  
Specific Protein ◽  
Dietary Factors ◽  
Lipid Signaling ◽  
Special Role ◽  
Aβ Peptides

Lipids participate in Amyloid Precursor Protein (APP) trafficking and processing - important factors in the initiation of Alzheimer’s disease (AD) pathogenesis and influence the formation of neurotoxic β-amyloid (Aβ) peptides. An important risk factor, the presence of ApoE4 protein in AD brain cells binds the lipids to AD. In addition, lipid signaling pathways have a crucial role in the cellular homeostasis and depend on specific protein-lipid interactions. The current review focuses on pathological alterations of membrane lipids (cholesterol, glycerophospholipids, sphingolipids) and lipid metabolism in AD and provides insight in the current understanding of biological membranes, their lipid structures and functions, as well as their role as potential therapeutic targets. Novel methods for studying the membrane structure and lipid composition will be reviewed in a broad sense whereas the use of lipid biomarkers for early diagnosis of AD will be shortly summarized. Interactions of Aβ peptides with the cell membrane and different subcellular organelles are reviewed. Next, the details of the most important lipid signaling pathways, including the role of the plasma membrane as stress sensor and its therapeutic applications are given. 4-hydroxy-2-nonenal may play a special role in the initiation of the pathogenesis of AD and thus the “calpain-cathepsin hypothesis” of AD is highlighted. Finally, the most important lipid dietary factors and their possible use and efficacy in the prevention of AD are discussed.

scholarly journals An Enzyme that Regulates Ether Lipid Signaling Pathways in Cancer Annotated by Multidimensional Profiling

2006 ◽  
Vol 13 (10) ◽  
pp. 1041-1050 ◽  
Author(s):  
Kyle P. Chiang ◽  
Sherry Niessen ◽  
Alan Saghatelian ◽  
Benjamin F. Cravatt
Keyword(s):  
Signaling Pathways ◽  
Ether Lipid ◽  
Lipid Signaling
Sign in / Sign up

Export Citation Format

Share Document