The Effect of Heaped and Sloped Powder Layers on Ejection Times and the Residence-Time Distribution of a Conical Mass-Flow Hopper

Author(s):  
Samuel Irvine ◽  
Luke Fullard ◽  
Clive Davies
Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 207 ◽  
Author(s):  
Jens Wesholowski ◽  
Andreas Berghaus ◽  
Markus Thommes

Over recent years Twin-Screw-Extrusion (TSE) has been established as a platform technology for pharmaceutical manufacturing. Compared to other continuous operation, one of the major benefits of this method is the combination of several unit operations within one apparatus. Several of these are linked to the Residence Time Distribution (RTD), which is typically expressed by the residence time density function. One relevant aspect for pharmaceutical processes is the mixing capacity, which is represented by the width of this distribution. In the frame of this study the influence of the mass flow, the temperature and the screw-barrel clearance were investigated for a constant barrel load (specific feed load, SFL). While the total mass flow as well as the external screw diameter affected the mixing performance, the barrel temperature had no influence for the investigated range. The determined results were additionally evaluated with respect to a fit to the Twin-Dispersion-Model (TDM). This model is based on the superimposition of two mixing functions. The correlations between varied process parameters and the obtained characteristic model parameters proved this general physical view on extrusion.


2021 ◽  
Vol 32 (2) ◽  
pp. 611-618
Author(s):  
Atena Dehghani Kiadehi ◽  
Mikel Leturia ◽  
Franco Otaola ◽  
Aissa Ould-Dris ◽  
Khashayar Saleh

Metals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 430
Author(s):  
Changyou Ding ◽  
Hong Lei ◽  
Hong Niu ◽  
Han Zhang ◽  
Bin Yang ◽  
...  

The residence time distribution (RTD) curve is widely applied to describe the fluid flow in a tundish, different tracer mass concentrations and different tracer volumes give different residence time distribution curves for the same flow field. Thus, it is necessary to have a deep insight into the effects of the mass concentration and the volume of tracer solution on the residence time distribution curve. In order to describe the interaction between the tracer and the fluid, solute buoyancy is considered in the Navier–Stokes equation. Numerical results show that, with the increase of the mass concentration and the volume of the tracer, the shape of the residence time distribution curve changes from single flat peak to single sharp peak and then to double peaks. This change comes from the stratified flow of the tracer. Furthermore, the velocity difference number is introduced to demonstrate the importance of the density difference between the tracer and the fluid.


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