Cancellous Bone Adaptation Predicted by Remodeling Simulations

2018 ◽  
pp. 91-101
Author(s):  
Yoshitaka Kameo ◽  
Ken-ichi Tsubota ◽  
Taiji Adachi
Keyword(s):  
Cancellous Bone ◽  
Bone Adaptation

scholarly journals Cancellous bone adaptation to in vivo loading in a rabbit model

Bone ◽  
2006 ◽  
Vol 38 (6) ◽  
pp. 871-877 ◽  
Author(s):  
Marjolein C.H. van der Meulen ◽  
Timothy G. Morgan ◽  
Xu Yang ◽  
Todd H. Baldini ◽  
Elizabeth R. Myers ◽  
...  
Keyword(s):  
Cancellous Bone ◽  
Rabbit Model ◽  
Bone Adaptation ◽  
In Vivo Loading

Two-week longitudinal survey of bone architecture alteration in the hindlimb-unloaded rat model of bone loss: sex differences

2006 ◽  
Vol 290 (3) ◽  
pp. E440-E447 ◽  
Author(s):  
Valentin David ◽  
Marie-Hélène Lafage-Proust ◽  
Norbert Laroche ◽  
Alexandre Christian ◽  
Peter Ruegsegger ◽  
...  
Keyword(s):  
Cancellous Bone ◽  
Bone Adaptation ◽  
Bone Volume ◽  
Hindlimb Unloading ◽  
Bone Architecture ◽  
Female Rats ◽  
Male Rats ◽  
Bone Formation Rate ◽  
Trabecular Thickness ◽  
Age Related

The goal of this study was to determine, through a longitudinal follow-up, whether sex influences bone adaptation during simulated weightlessness. Twelve-week-old male and female Wistar rats were hindlimb unweighted for 2 wk, and the time course of bone alteration was monitored in vivo by means of densitometry and unbiased three-dimensional quantitative microcomputed tomography at 7 and 14 days. Compared with male rats, female rats had twice more cancellous bone volume at the proximal tibia at baseline, and this bone volume continued to increase, whereas in males it stabilized. Conversely, cortical area was greater in males than in females, and in both sexes cortical bone was still expanding. Hindlimb unloading resulted in larger reductions in males than in females in both cortical and cancellous compartments. In females, trabecular thickness and number decreased mildly, whereas in males trabecular number was dramatically reduced. In both sexes, the trabecular network became less connected and more rod-like shaped. Bone cellular activities evaluated by histomorphometry showed decreased bone formation rate in both sexes and increased resorption activity only in males. In conclusion, in female rats unloaded-related cancellous alterations reversed the growing process, whereas in males, which show lower growth process, it induced an accentuation of age-related cancellous bone changes for most of the parameters.

scholarly journals Simulated spaceflight produces a rapid and sustained loss of osteoprogenitors and an acute but transitory rise of osteoclast precursors in two genetic strains of mice

2012 ◽  
Vol 303 (11) ◽  
pp. E1354-E1362 ◽  
Author(s):  
Mohammad Shahnazari ◽  
Pam Kurimoto ◽  
Benjamin M. Boudignon ◽  
Benjamin E. Orwoll ◽  
Daniel D. Bikle ◽  
...  
Keyword(s):  
Bone Loss ◽  
Cancellous Bone ◽  
Bone Structure ◽  
Bone Cells ◽  
Weight Bearing ◽  
Bone Adaptation ◽  
Hindlimb Unloading ◽  
Skeletal Unloading ◽  
Precursor Pool ◽  
Cancellous Bone Structure

Loss of skeletal weight bearing or skeletal unloading as occurs during spaceflight inhibits bone formation and stimulates bone resorption. These are associated with a decline in the osteoblast (Ob.S/BS) and an increase in the osteoclast (Oc.S/BS) bone surfaces. To determine the temporal relationship between changes in the bone cells and their marrow precursor pools during sustained unloading, and whether genetic background influences these relationships, we used the hindlimb unloading model to induce bone loss in two strains of mice known to respond to load and having significantly different cancellous bone volumes (C57BL/6 and DBA/2 male mice). Skeletal unloading caused a progressive decline in bone volume that was accompanied by strain-specific changes in Ob.S/BS and Oc.S/BS. These were associated with a sustained reduction in the osteoprogenitor population and a dramatic but transient increase in the osteoclast precursor pool size in both strains. The results reveal that bone adaptation to skeletal unloading involves similar rapid changes in the osteoblast and osteoclast progenitor populations in both strains of mice but striking differences in Oc.S/BS dynamics, BFR, and cancellous bone structure. These strain-specific differences suggest that genetics plays an important role in determining the osteoblast and osteoclast populations on the bone surface and the dynamics of bone loss in response to skeletal unloading.

scholarly journals Cancellous bone adaptation to tibial compression is not sex dependent in growing mice

2010 ◽  
Vol 109 (3) ◽  
pp. 685-691 ◽  
Author(s):  
Maureen E. Lynch ◽  
Russell P. Main ◽  
Qian Xu ◽  
Daniel J. Walsh ◽  
Mitchell B. Schaffler ◽  
...  
Keyword(s):  
Bone Mass ◽  
Mechanical Loading ◽  
Cancellous Bone ◽  
Adaptive Response ◽  
Bone Adaptation ◽  
Micro Computed Tomography ◽  
Element Analysis ◽  
Male And Female ◽  
And Control

Mechanical loading can be used to increase bone mass and thus attenuate pathological bone loss. Because the skeleton's adaptive response to loading is most robust before adulthood, elucidating sex-specific responses during growth may help maximize peak bone mass. This study investigated the effect of sex on the response to controlled, in vivo mechanical loading in growing mice. Ten-week-old male and female C57Bl/6 mice underwent noninvasive compression of the left tibia. Peak loads of −11.5 N were applied, corresponding to +1,200 με at the tibial midshaft in both sexes. Cancellous bone mass, architecture, and dynamic formation in the proximal metaphysis were compared between loaded and control limbs via micro-computed tomography and histomorphometry. The strain environment of the proximal metaphysis during loading was characterized using finite element analysis. Both sexes responded to tibial compression through increased bone mass and altered architecture. Cancellous bone mass and tissue density were enhanced in loaded limbs relative to control limbs in both sexes through trabecular thickening and reduced separation. Changes in mass were due to increased cellular activity in loaded limbs compared with control limbs. Adaptation to loading increased the proportion of load transferred by the cancellous bone in the proximal metaphysis. For all cancellous measures, the response to tibial compression did not differ between male and female mice. When similar strains are engendered in males and females, the adaptive response in cancellous bone to mechanical loading does not depend on sex.

Model of cancellous bone adaptation considering hypermineralised bone tissue

2012 ◽  
Vol 15 (sup1) ◽  
pp. 353-354
Author(s):  
C. Chan Yone ◽  
J. L. Milan ◽  
J. M. Rossi ◽  
J. F. Witz ◽  
M. Brieu ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Cancellous Bone ◽  
Bone Adaptation

The Repair and Healing of Two Traumatic Ilial Body Fractures Adjacent to Cemented Total Hip Acetabular Components

1992 ◽  
Vol 05 (02) ◽  
pp. 85-89
Author(s):  
P. K. Shires ◽  
T. L. Dew
Keyword(s):  
Internal Fixation ◽  
Cancellous Bone ◽  
Surgical Techniques ◽  
Autogenous Bone ◽  
Cancellous Bone Graft ◽  
Standard Methods ◽  
Intravenous Antibiotics ◽  
Prophylactic Use ◽  
Acetabular Components ◽  
Autogenous Bone Grafts

SummaryThis report has documented the repair and healing of two ilial fractures in dogs which were compounded by the presence of a cemented acetabular prosthesis. While specific recommendations can not be made from such a small number of cases, the information presented herein suggests that such fractures will heal without complication if aseptic surgical techniques and standard methods of internal fixation are employed. The authors strongly recommend the prophylactic use of intravenous antibiotics and the placement of cancellous bone graft when the repair of such fractures is attempted.Two traumatic ilial fractures involving the cement/bone interface of acetabular prostheses were repaired using lag screws, cerclage wires, and autogenous bone grafts. The fractures healed and ambulatory function was regained.

Arthrodesis of the Distal Two Tarsal Joints in the Horse Using Perforated Stainless Steel Cylinders and Cancellous Bone Graft

1991 ◽  
Vol 4 (01) ◽  
pp. 21-27 ◽  
Author(s):  
R. M. Archer ◽  
R. K. Schneider
Keyword(s):  
Stainless Steel ◽  
Bone Graft ◽  
Cancellous Bone ◽  
Cancellous Bone Graft ◽  
The Third ◽  
Partial Fusion

SummaryTwo perforated stainless steel cylinders and autogenous cancellous bone were implanted into each of the distal intertarsal and tarsometatarsal joints of seven horses. In two control horses holes were drilled into each joint and autogenous cancellous bone was implanted without stainless steel cylinders. Horses which had cylinders implanted in the distal tarsal joints exhibited less lameness and were more comfortable following surgery than were the control horses. Fracture of the third tarsal, central tarsal, or third metatarsal occurred in five of the seven horses implanted with stainless steel cylinders within 45 days of surgery. Two implanted horses and two control horses were observed for five months after surgery. Partial fusion of the distal tarsal joints occurred in all four horses. Control horses were more lame than the implanted horses and developed a large bony exostosis over the medial distal tarsus.

Cortico-cancellous bone allografting in treatment of children with orthopedic diseases

2017 ◽  
Author(s):  
Mikhail Mikhovich ◽  
Leanid Hlazkin ◽  
Viktoryja Kazlova
Keyword(s):  
Cancellous Bone ◽  
Orthopedic Diseases
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