Regenerative Medicine: Current and Potential Applications

2011 ◽  
pp. 75-94
Author(s):  
Alfonso Barbarisi ◽  
Francesco Rosso
Keyword(s):  
Regenerative Medicine ◽  
Potential Applications

Biodegradable porous beads and their potential applications in regenerative medicine

2012 ◽  
Vol 22 (23) ◽  
pp. 11442 ◽  
Author(s):  
Sung-Wook Choi ◽  
Yu Zhang ◽  
Yi-Chun Yeh ◽  
A. Lake Wooten ◽  
Younan Xia
Keyword(s):  
Regenerative Medicine ◽  
Potential Applications ◽  
Porous Beads

scholarly journals Additive Manufacturing of Biopolymers for Tissue Engineering and Regenerative Medicine: An Overview, Potential Applications, Advancements, and Trends

2021 ◽  
Vol 2021 ◽  
pp. 1-20 ◽  
Author(s):  
Dhinakaran Veeman ◽  
M. Swapna Sai ◽  
P. Sureshkumar ◽  
T. Jagadeesha ◽  
L. Natrayan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Three Dimensional ◽  
Porous Scaffolds ◽  
Wide Range ◽  
Potential Applications ◽  
Pharmaceutical Industries

As a technique of producing fabric engineering scaffolds, three-dimensional (3D) printing has tremendous possibilities. 3D printing applications are restricted to a wide range of biomaterials in the field of regenerative medicine and tissue engineering. Due to their biocompatibility, bioactiveness, and biodegradability, biopolymers such as collagen, alginate, silk fibroin, chitosan, alginate, cellulose, and starch are used in a variety of fields, including the food, biomedical, regeneration, agriculture, packaging, and pharmaceutical industries. The benefits of producing 3D-printed scaffolds are many, including the capacity to produce complicated geometries, porosity, and multicell coculture and to take growth factors into account. In particular, the additional production of biopolymers offers new options to produce 3D structures and materials with specialised patterns and properties. In the realm of tissue engineering and regenerative medicine (TERM), important progress has been accomplished; now, several state-of-the-art techniques are used to produce porous scaffolds for organ or tissue regeneration to be suited for tissue technology. Natural biopolymeric materials are often better suited for designing and manufacturing healing equipment than temporary implants and tissue regeneration materials owing to its appropriate properties and biocompatibility. The review focuses on the additive manufacturing of biopolymers with significant changes, advancements, trends, and developments in regenerative medicine and tissue engineering with potential applications.

Morpholino-functionalized phosphorus dendrimers for precision regenerative medicine: osteogenic differentiation of mesenchymal stem cells

Nanoscale ◽  
2019 ◽  
Vol 11 (37) ◽  
pp. 17230-17234
Author(s):  
Aijun Li ◽  
Yu Fan ◽  
Xueyan Cao ◽  
Liang Chen ◽  
Le Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Bone Regeneration ◽  
Osteogenic Differentiation ◽  
Potential Applications

Morpholino-functionalized phosphorus dendrimers strongly promote the transformation of mesenchymal stem cells into osteoblasts for potential applications in bone regeneration.

scholarly journals Somatic cell nuclear transfer: failures, successes and the challenges ahead

2019 ◽  
Vol 63 (3-4-5) ◽  
pp. 123-130 ◽  
Author(s):  
Marta Czernik ◽  
Debora A. Anzalone ◽  
Luca Palazzese ◽  
Mami Oikawa ◽  
Pasqualino Loi
Keyword(s):  
Endangered Species ◽  
Regenerative Medicine ◽  
Somatic Cell ◽  
Somatic Cell Nuclear Transfer ◽  
Nuclear Transfer ◽  
Transgenic Animals ◽  
Factors Affecting ◽  
Potential Applications ◽  
Mitochondrial Defects ◽  
Species Production

Somatic cell nuclear transfer (SCNT) has a broad spectrum of potential applications, including rescue of endangered species, production of transgenic animals, drug production, and regenerative medicine. Unfortunately, the efficiency of SCNT is still disappointingly low. Many factors affecting cloning procedures have been described in several previous reviews; here we review the most effective improvements in SCNT, with a special emphasis on the effect of mitochondrial defects on SCNT embryo/ foetus development, an issue never touched upon before.

scholarly journals Parthenogenesis and Human Assisted Reproduction

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Adriana Bos-Mikich ◽  
Fabiana F. Bressan ◽  
Rafael R. Ruggeri ◽  
Yeda Watanabe ◽  
Flávio V. Meirelles
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Assisted Reproduction ◽  
Embryonic Stem ◽  
Human Oocytes ◽  
Assisted Reproduction Technologies ◽  
Infertility Treatments ◽  
Potential Applications ◽  
Stem Cell Lines ◽  
Artificial Activation

Parthenogenetic activation of human oocytes obtained from infertility treatments has gained new interest in recent years as an alternative approach to create embryos with no reproductive purpose for research in areas such as assisted reproduction technologies itself, somatic cell, and nuclear transfer experiments and for derivation of clinical grade pluripotent embryonic stem cells for regenerative medicine. Different activating methods have been tested on human and nonhuman oocytes, with varying degrees of success in terms of parthenote generation rates, embryo development stem cell derivation rates. Success in achieving a standardized artificial activation methodology for human oocytes and the subsequent potential therapeutic gain obtained from these embryos depends mainly on the availability of gametes donated from infertility treatments. This review will focus on the creation of parthenotes from clinically unusable oocytes for derivation and establishment of human parthenogenetic stem cell lines and their potential applications in regenerative medicine.

scholarly journals The Human Skin-Derived Precursors for Regenerative Medicine: Current State, Challenges, and Perspectives

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Ru Dai ◽  
Wei Hua ◽  
Heng Xie ◽  
Wei Chen ◽  
Lidan Xiong ◽  
...  
Keyword(s):  
Regenerative Medicine ◽  
Adult Stem Cell ◽  
Biological Properties ◽  
Culture Methods ◽  
Stem Cell Source ◽  
Cell Based Therapy ◽  
Potential Applications ◽  
Innovative Culture

Skin-derived precursors (SKPs) are an adult stem cell source with self-renewal and multipotent differentiation. Although rodent SKPs have been discussed in detail in substantial studies, human SKPs (hSKPs) are rarely reported. Understanding the biological properties and possible mechanisms underlying hSKPs has important implications for regenerative medicine particularly clinical applications, as human-derived sources are more suitable for clinical transplantation. The finding that hSKPs derivatives, such as neural and mesodermal progeny, have bothin vitroandin vivofunction without any genetical modification makes hSKPs a trustable, secure, and accessible resource for cell-based therapy. Here, we provide an overview of hSKPs, describing their characteristics, originations and niches, and potential applications. A comparison between traditional and innovative culture methods used for hSKPs is also introduced. Furthermore, we discuss the challenges and the future perspectives towards the field of hSKPs. With this review, we hope to point out the current stage of hSKPs and highlight the problems that remain in this field.

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