scholarly journals Additive Manufacturing of Biopolymers for Tissue Engineering and Regenerative Medicine: An Overview, Potential Applications, Advancements, and Trends

2021 ◽  
Vol 2021 ◽  
pp. 1-20 ◽  
Author(s):  
Dhinakaran Veeman ◽  
M. Swapna Sai ◽  
P. Sureshkumar ◽  
T. Jagadeesha ◽  
L. Natrayan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Three Dimensional ◽  
Porous Scaffolds ◽  
Wide Range ◽  
Potential Applications ◽  
Pharmaceutical Industries

As a technique of producing fabric engineering scaffolds, three-dimensional (3D) printing has tremendous possibilities. 3D printing applications are restricted to a wide range of biomaterials in the field of regenerative medicine and tissue engineering. Due to their biocompatibility, bioactiveness, and biodegradability, biopolymers such as collagen, alginate, silk fibroin, chitosan, alginate, cellulose, and starch are used in a variety of fields, including the food, biomedical, regeneration, agriculture, packaging, and pharmaceutical industries. The benefits of producing 3D-printed scaffolds are many, including the capacity to produce complicated geometries, porosity, and multicell coculture and to take growth factors into account. In particular, the additional production of biopolymers offers new options to produce 3D structures and materials with specialised patterns and properties. In the realm of tissue engineering and regenerative medicine (TERM), important progress has been accomplished; now, several state-of-the-art techniques are used to produce porous scaffolds for organ or tissue regeneration to be suited for tissue technology. Natural biopolymeric materials are often better suited for designing and manufacturing healing equipment than temporary implants and tissue regeneration materials owing to its appropriate properties and biocompatibility. The review focuses on the additive manufacturing of biopolymers with significant changes, advancements, trends, and developments in regenerative medicine and tissue engineering with potential applications.

3D printing in tissue engineering: a state of the art review of technologies and biomaterials

2020 ◽  
Vol 26 (7) ◽  
pp. 1313-1334 ◽  
Author(s):  
Nataraj Poomathi ◽  
Sunpreet Singh ◽  
Chander Prakash ◽  
Arjun Subramanian ◽  
Rahul Sahay ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Regenerative Medicine ◽  
State Of The Art ◽  
Three Dimensional ◽  
Cost Effective ◽  
Cochrane Library ◽  
Content Type ◽  
Wide Range ◽  
Potential Applications

Purpose In the past decade, three-dimensional (3D) printing has gained attention in areas such as medicine, engineering, manufacturing art and most recently in education. In biomedical, the development of a wide range of biomaterials has catalysed the considerable role of 3D printing (3DP), where it functions as synthetic frameworks in the form of scaffolds, constructs or matrices. The purpose of this paper is to present the state-of-the-art literature coverage of 3DP applications in tissue engineering (such as customized scaffoldings and organs, and regenerative medicine). Design/methodology/approach This review focusses on various 3DP techniques and biomaterials for tissue engineering (TE) applications. The literature reviewed in the manuscript has been collected from various journal search engines including Google Scholar, Research Gate, Academia, PubMed, Scopus, EMBASE, Cochrane Library and Web of Science. The keywords that have been selected for the searches were 3 D printing, tissue engineering, scaffoldings, organs, regenerative medicine, biomaterials, standards, applications and future directions. Further, the sub-classifications of the keyword, wherever possible, have been used as sectioned/sub-sectioned in the manuscript. Findings 3DP techniques have many applications in biomedical and TE (B-TE), as covered in the literature. Customized structures for B-TE applications are easy and cost-effective to manufacture through 3DP, whereas on many occasions, conventional technologies generally become incompatible. For this, this new class of manufacturing must be explored to further capabilities for many potential applications. Originality/value This review paper presents a comprehensive study of the various types of 3DP technologies in the light of their possible B-TE application as well as provides a future roadmap.

scholarly journals Editorial for the Special Issue on 3D Printing for Tissue Engineering and Regenerative Medicine

Micromachines ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 366 ◽  
Author(s):  
Vahid Serpooshan ◽  
Murat Guvendiren
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Three Dimensional ◽  
Living Cells ◽  
3D Bioprinting ◽  
Special Issue ◽  
3D Structures ◽  
Manufacturing Techniques

Three-dimensional (3D) bioprinting uses additive manufacturing techniques to fabricate 3D structures consisting of heterogenous selections of living cells, biomaterials, and active biomolecules [...]

scholarly journals 3D Printing for Soft Tissue Regeneration and Applications in Medicine

Biomedicines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 336
Author(s):  
Sven Pantermehl ◽  
Steffen Emmert ◽  
Aenne Foth ◽  
Niels Grabow ◽  
Said Alkildani ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Soft Tissue ◽  
3D Printing ◽  
Tissue Regeneration ◽  
Research Area ◽  
Modern Medicine ◽  
Soft Tissue Regeneration ◽  
General Overview

The use of additive manufacturing (AM) technologies is a relatively young research area in modern medicine. This technology offers a fast and effective way of producing implants, tissues, or entire organs individually adapted to the needs of a patient. Today, a large number of different 3D printing technologies with individual application areas are available. This review is intended to provide a general overview of these various printing technologies and their function for medical use. For this purpose, the design and functionality of the different applications are presented and their individual strengths and weaknesses are explained. Where possible, previous studies using the respective technologies in the field of tissue engineering are briefly summarized.

scholarly journals Advances in 3D Printing for Tissue Engineering

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3149
Author(s):  
Angelika Zaszczyńska ◽  
Maryla Moczulska-Heljak ◽  
Arkadiusz Gradys ◽  
Paweł Sajkiewicz
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Complex Structure ◽  
Three Dimensional ◽  
Computer Assisted ◽  
Scaffold Fabrication ◽  
Manufacturing Techniques ◽  
Printing Techniques ◽  
State Of Art

Tissue engineering (TE) scaffolds have enormous significance for the possibility of regeneration of complex tissue structures or even whole organs. Three-dimensional (3D) printing techniques allow fabricating TE scaffolds, having an extremely complex structure, in a repeatable and precise manner. Moreover, they enable the easy application of computer-assisted methods to TE scaffold design. The latest additive manufacturing techniques open up opportunities not otherwise available. This study aimed to summarize the state-of-art field of 3D printing techniques in applications for tissue engineering with a focus on the latest advancements. The following topics are discussed: systematics of the available 3D printing techniques applied for TE scaffold fabrication; overview of 3D printable biomaterials and advancements in 3D-printing-assisted tissue engineering.

scholarly journals Biomimicry in Bio-Manufacturing: Developments in Melt Electrospinning Writing Technology Towards Hybrid Biomanufacturing

2019 ◽  
Vol 9 (17) ◽  
pp. 3540 ◽  
Author(s):  
Ferdows Afghah ◽  
Caner Dikyol ◽  
Mine Altunbek ◽  
Bahattin Koc
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Cell Attachment ◽  
Three Dimensional ◽  
Future Perspective ◽  
Melt Electrospinning ◽  
Wide Range ◽  
Challenges And Opportunities ◽  
Potential Applications ◽  
Homogeneous Cell

Melt electrospinning writing has been emerged as a promising technique in the field of tissue engineering, with the capability of fabricating controllable and highly ordered complex three-dimensional geometries from a wide range of polymers. This three-dimensional (3D) printing method can be used to fabricate scaffolds biomimicking extracellular matrix of replaced tissue with the required mechanical properties. However, controlled and homogeneous cell attachment on melt electrospun fibers is a challenge. The combination of melt electrospinning writing with other tissue engineering approaches, called hybrid biomanufacturing, has introduced new perspectives and increased its potential applications in tissue engineering. In this review, principles and key parameters, challenges, and opportunities of melt electrospinning writing, and particularly, recent approaches and materials in this field are introduced. Subsequently, hybrid biomanufacturing strategies are presented for improved biological and mechanical properties of the manufactured porous structures. An overview of the possible hybrid setups and applications, future perspective of hybrid processes, guidelines, and opportunities in different areas of tissue/organ engineering are also highlighted.

scholarly journals 3D-Printed Biopolymers for Tissue Engineering Application

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Xiaoming Li ◽  
Rongrong Cui ◽  
Lianwen Sun ◽  
Katerina E. Aifantis ◽  
Yubo Fan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Three Dimensional ◽  
Engineering Application ◽  
Tissue Engineering Application ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Potential Applications ◽  
3D Printed ◽  
Dimensional Object

3D printing technology has recently gained substantial interest for potential applications in tissue engineering due to the ability of making a three-dimensional object of virtually any shape from a digital model. 3D-printed biopolymers, which combine the 3D printing technology and biopolymers, have shown great potential in tissue engineering applications and are receiving significant attention, which has resulted in the development of numerous research programs regarding the material systems which are available for 3D printing. This review focuses on recent advances in the development of biopolymer materials, including natural biopolymer-based materials and synthetic biopolymer-based materials prepared using 3D printing technology, and some future challenges and applications of this technology are discussed.

scholarly journals Bioinspired Materials 2018: Conference Report

Biomimetics ◽  
2019 ◽  
Vol 4 (1) ◽  
pp. 4 ◽  
Author(s):  
Marloes Peeters ◽  
Patricia Linton ◽  
Araida Hidalgo-Bastida
Keyword(s):  
Tissue Engineering ◽  
Fuel Cell ◽  
3D Printing ◽  
Three Dimensional ◽  
Conference Report ◽  
Materials Chemistry ◽  
The Third ◽  
Wide Range ◽  
Bioinspired Materials ◽  
Metropolitan University

The Bioinspired Materials conference 2018 was organized for the third time by a team of researchers from Manchester Metropolitan University. This international conference aims to bring together the scientific committee in the fields of biomimetic sensors, bioinspired materials, materials chemistry, three-dimensional (3D) printing, and tissue engineering. The 2018 edition was held at the John Dalton Building of Manchester Metropolitan University, Manchester, UK, and took place on the 10th of October 2018. There were over 60 national and international attendees, with the international attendees participating in a lab tour through the synthetic facilities and Fuel Cell Innovation Centre on the 9th of October. The three conference sessions encompassed a wide range of topics, varying from biomimetic sensors, hydrogels, and biofabrics and bioengineering.

Importance of 3D Printing Technology in Medical Fields

2019 ◽  
pp. 21-40
Author(s):  
Ranjit Barua ◽  
Sudipto Datta ◽  
Amit Roychowdhury ◽  
Pallab Datta
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
New Technology ◽  
Three Dimensional ◽  
Layer By Layer ◽  
Medical Field ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Proper Material

Three-dimensional or 3D printing technology is a growing interest in medical fields like tissue engineering, dental, drug delivery, prosthetics, and implants. It is also known as the additive manufacturing (AM) process because the objects are done by extruding or depositing the material layer by layer, and the material may be like biomaterials, plastics, living cells, or powder ceramics. Specially in the medical field, this new technology has importance rewards in contrast with conventional technologies, such as the capability to fabricate patient-explicit difficult components, desire scaffolds for tissue engineering, and proper material consumption. In this chapter, different types of additive manufacturing (AM) techniques are described that are applied in the medical field, especially in community health and precision medicine.

A Parallel Multiple Layer Cryolithography Device for the Manufacture of Biological Material for Tissue Engineering

2019 ◽  
Vol 13 (3) ◽  
Author(s):  
Gideon Ukpai ◽  
Joseph Sahyoun ◽  
Robert Stuart ◽  
Sky Wang ◽  
Zichen Xiao ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
3D Structure ◽  
Three Dimensional ◽  
3D Object ◽  
New Device ◽  
Biological Matter ◽  
Simple Product ◽  
Printing Processes

While three-dimensional (3D) printing of biological matter is of increasing interest, current linear 3D printing processes lack the efficiency at scale required to mass manufacture products made of biological matter. This paper introduces a device for a newly developed parallel additive manufacturing technology for production of 3D objects, which addresses the need for faster, industrial scale additive manufacturing methods. The technology uses multilayer cryolithography (MLCL) to make biological products faster and in larger quantities by simultaneously printing two-dimensional (2D) layers in parallel and assembling the layers into a 3D structure at an assembly site, instead of sequentially and linearly assembling a 3D object from individual elements as in conventional 3D printing. The technique uses freezing to bind the 2D layers together into a 3D object. This paper describes the basic principles of MLCL and demonstrates the technology with a new device used to manufacture a very simple product that could be used for tissue engineering, as an example. An evaluation of the interlayer bonding shows that a continuous and coherent structure can be made from the assembly of distinct layers using MLCL.

scholarly journals A pilot study on the use of 3D printers in veterinary medicine

2021 ◽  
Vol 14 (3) ◽  
pp. 159-164
Author(s):  
Leonardo Leonardi ◽  
◽  
Roberto Marsili ◽  
Enrico Bellezza ◽  
Giovanni Angeli ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Bone Tissue ◽  
Three Dimensional ◽  
The Body ◽  
Porous Scaffolds ◽  
Layer By Layer ◽  
Three Dimensional Objects ◽  
Cellular Attachment

Additive manufacturing (AM) is the process of joining materials to create layer-by-layer three-dimensional objects using a 3D printer from a digital model. The great advantage of Additive Manufacturing is to allow a freer design than traditional processes. The development of additive manufacturing processes has permitted to optimize the production of the customized product through the modeling of the geometry and the knowledge of the morphometric parameters of the body structures. 3D printing has revolutionized the field of Regenerative Medicine because, starting from computerized tomography (CT) images and using traditional materials such as plastic and metals, it can provide customized prostheses for each patient, which adapt perfectly to the needs of the subject and act as structures support. 3D printing allows you to print three-dimensional porous scaffolds with a precise shape and chemical composition suitable for medical and veterinary use. Some of these scaffolds are biodegradable and appear to be ideal for bone tissue engineering. In fact, they are able to simulate extracellular matrix properties that allow mechanical support, favoring mechanical interactions and providing a model for cellular attachment and in vivo stimulation of bone tissue formation.

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