Development of Edible Plant Vaccines

2010 ◽  
pp. 497-501
Author(s):  
Heike Mikschofsky ◽  
Patricia König ◽  
Günther Keil ◽  
Horst Schirrmeier ◽  
Inge Broer
Keyword(s):  
2002 ◽  
Vol 8 (7) ◽  
pp. 324-329 ◽  
Author(s):  
Hugh S. Mason ◽  
Heribert Warzecha ◽  
Tsafrir Mor ◽  
Charles J. Arntzen

1996 ◽  
Vol 14 (11) ◽  
pp. 1532-1533 ◽  
Author(s):  
Emma Johnson
Keyword(s):  

2021 ◽  
Vol 22 (15) ◽  
pp. 8223
Author(s):  
Violetta Krajka-Kuźniak ◽  
Wanda Baer-Dubowska

Nrf2 (nuclear factor erythroid 2-related factor 2) and NF-κB (nuclear factor–kappa B) signaling pathways play a central role in suppressing or inducing inflammation and angiogenesis processes. Therefore, they are involved in many steps of carcinogenesis through cooperation with multiple signaling molecules and pathways. Targeting both transcription factors simultaneously may be considered an equally important strategy for cancer chemoprevention and therapy. Several hundreds of phytochemicals, mainly edible plant and vegetable components, were shown to activate Nrf2 and mediate antioxidant response. A similar number of phytochemicals was revealed to affect NF-κB. While activation of Nrf2 and inhibition of NF-κB may protect normal cells against cancer initiation and promotion, enhanced expression and activation in cancer cells may lead to resistance to conventional chemo- or radiotherapy. Most phytochemicals, through different mechanisms, activate Nrf2, but others, such as luteolin, can act as inhibitors of both Nrf2 and NF-κB. Despite many experimental data confirming the above mechanisms currently, limited evidence exists demonstrating such activity in humans. Combinations of phytochemicals resembling that in a natural food matrix but allowing higher concentrations may improve their modulating effect on Nrf2 and NF-κB and ultimately cancer prevention and therapy. This review presents the current knowledge on the effect of selected phytochemicals and their combinations on Nrf2 and NF-κB activities in the above context.


2021 ◽  
Vol 21 (1) ◽  
pp. 609-618
Author(s):  
R.K. Maikhuri ◽  
Dalbeer S. Parshwan ◽  
Pushpa Kewlani ◽  
Vikram S. Negi ◽  
Sandeep Rawat ◽  
...  

Author(s):  
Kelly Alencar Silva ◽  
Thais Matsue Uekane ◽  
Jeniffer Ferreira de Miranda ◽  
Larissa Fernandes Ruiz ◽  
Juliana Cristini Brum da Motta ◽  
...  

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3712
Author(s):  
Ryan D. Rattray ◽  
Ben-Erik Van Wyk

The Lamiaceae is undoubtedly an important plant family, having a rich history of use that spans the globe with many species being used in folk medicine and modern industries alike. Their ability to produce aromatic volatile oils has made them valuable sources of materials in the cosmetic, culinary, and pharmaceutical industries. A thorough account of the taxonomic diversity, chemistry and ethnobotany is lacking for southern African Lamiaceae, which feature some of the region’s most notable medicinal and edible plant species. We provide a comprehensive insight into the Lamiaceae flora of southern Africa, comprising 297 species in 42 genera, 105 of which are endemic to the subcontinent. We further explore the medicinal and traditional uses, where all genera with documented uses are covered for the region. A broad review of the chemistry of southern African Lamiaceae is presented, noting that only 101 species (34%) have been investigated chemically (either their volatile oils or phytochemical characterization of secondary metabolites), thus presenting many and varied opportunities for further studies. The main aim of our study was therefore to present an up-to-date account of the botany, chemistry and traditional uses of the family in southern Africa, and to identify obvious knowledge gaps.


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