A Framework for Constructive Design Rationale

2011 ◽  
pp. 135-153 ◽  
Author(s):  
Udo Kannengiesser ◽  
John S. Gero
Keyword(s):  
Design Rationale

Clustering-Triggered Efficient Room Temperature Phosphorescence from Nonconventional Luminophores

2019 ◽  
Author(s):  
Shuyuan Zheng ◽  
Taiping Hu ◽  
Xin Bin ◽  
Yunzhong Wang ◽  
Yuanping Yi ◽  
...  
Keyword(s):  
Room Temperature ◽  
High Efficiency ◽  
Spin Orbit Coupling ◽  
Design Rationale ◽  
Emission Mechanism ◽  
Room Temperature Phosphorescence ◽  
Electronic Interactions ◽  
Energy Gaps ◽  
Theoretical Results

Pure organic room temperature phosphorescence (RTP) and luminescence from nonconventional luminophores have gained increasing attention. However, it remains challenging to achieve efficient RTP from unorthodox luminophores, on account of the unsophisticated understanding of the emission mechanism. Here we propose a strategy to realize efficient RTP in nonconventional luminophores through incorporation of lone pairs together with clustering and effective electronic interactions. The former promotes spin-orbit coupling and boost the consequent intersystem crossing, whereas the latter narrows energy gaps and stabilizes the triplets, thus synergistically affording remarkable RTP. Experimental and theoretical results of urea and its derivatives verify the design rationale. Remarkably, RTP from thiourea solids with unprecedentedly high efficiency of up to 24.5% is obtained. Further control experiments testify the crucial role of through-space delocalization on the emission. These results would spur the future fabrication of nonconventional phosphors, and moreover should advance understanding of the underlying emission mechanism.<br>

How to Fluorescently Label the Potassium Channel: A Case in hERG

2020 ◽  
Vol 27 (18) ◽  
pp. 3046-3054
Author(s):  
Xiaomeng Zhang ◽  
Beilei Wang ◽  
Zhenzhen Liu ◽  
Yubin Zhou ◽  
Lupei Du
Keyword(s):  
Potassium Channel ◽  
Herg Channel ◽  
Pore Channel ◽  
Design Rationale ◽  
Related Gene ◽  
Open Conformation ◽  
Cardiac Action ◽  
Qt Syndrome ◽  
Herg Channels ◽  
Action Potential Repolarization

hERG (Human ether-a-go-go-related gene) potassium channel, which plays an essential role in cardiac action potential repolarization, is responsible for inherited and druginduced long QT syndrome. Recently, the Cryo-EM structure capturing the open conformation of hERG channel was determined, thus pushing the study on hERG channel at 3.8 Å resolution. This report focuses primarily on summarizing the design rationale and application of several fluorescent probes that target hERG channels, which enables dynamic and real-time monitoring of potassium pore channel affinity to further advance the understanding of the channels.

scholarly journals A DESIGN RATIONALE ANALYSIS METHOD TOWARDS ROBUST ARTIFACT DESIGN

2021 ◽  
Vol 1 ◽  
pp. 71-80
Author(s):  
Yusuke Tsutsui ◽  
Yuya Mitake ◽  
Mar'atus Sholihah ◽  
Shigeru Hosono ◽  
Yoshiki Shimomura
Keyword(s):  
Robust Design ◽  
Design Rationale ◽  
Analysis Method ◽  
The Past ◽  
Previous Design ◽  
Artifact Design

AbstractTo design a more robust artifact, an artifact design based on a design rationale analysis is pivotal. Errors in previous design rationales that led to the degradation of artifact robustness in the past provide valuable knowledge towards improving the robust design. However, methods for exposing and analysing errors in design rationale remain unclear. This paper proposes a structured method for a design rationale analysis based on logical structuring. This method provides a well-constructed means of identifying and analysing errors in design rationale from the perspective of knowledge operation.

DRed and Design Folders: A Way of Capturing, Storing and Passing On Knowledge Generated During Design Projects

2004 ◽  
Author(s):  
Rob H. Bracewell ◽  
Saeema Ahmed ◽  
Ken M. Wallace
Keyword(s):  
Software Tool ◽  
Preliminary Evaluation ◽  
Design Rationale ◽  
Knowledge Model ◽  
Design Data ◽  
Design Work ◽  
High Profile ◽  
Design Projects ◽  
Design Case Study ◽  
Or Team

This paper describes a software tool called DRed (the Design Rationale editor), that allows engineering designers to record their design rationale (DR) at the time of its generation and deliberation. DRed is one of many proposed derivatives of the venerable IBIS concept, but by contrast with other tools of this type, practicing designers appear surprisingly willing to use it. DRed allows the issues addressed, options considered, and associated arguments for and against, to be captured graphically. The software, despite still being essentially a research prototype, is already in use on high profile design projects in an international aerospace company, including the presentation of results of design work to external customers. The paper compares DRed with other IBIS-derived software tools, to explain how it addresses problems that seem to have made them unsuitable for routine use by designers. In addition to the capture and presentation of the DR itself, the set of linked DR graphs can be used to provide a map of the contents of an electronic Design Folder, containing all the documents created by an individual or team during a design project. The structure of the knowledge model instantiated in such a Design Folder is described. By reprising a design case study published at the DTM 2003 conference, concerning the design of a Mobile Arm Support (MAS), the DRed knowledge model is compared with the previously proposed Design Data Model (DDM), to show how it addresses the shortcomings identified in the DDM. Finally the methodology and results of the preliminary evaluation of the use of DRed by aerospace designers are presented.

scholarly journals The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods

2015 ◽  
Vol 20 (2) ◽  
pp. 893-900 ◽  
Author(s):  
Brian B. Koo ◽  
Christine Won ◽  
Bernardo J. Selim ◽  
Li Qin ◽  
Sangchoon Jeon ◽  
...  
Keyword(s):  
Study Design ◽  
Design Rationale ◽  
Vascular Events ◽  
Apnea Monitoring

scholarly journals Real-time point of care microcirculatory assessment of shock: design, rationale and application of the point of care microcirculation (POEM) tool

Critical Care ◽  
2016 ◽  
Vol 20 (1) ◽  
Author(s):  
David N. Naumann ◽  
Clare Mellis ◽  
Shamus L. G. Husheer ◽  
Philip Hopkins ◽  
Jon Bishop ◽  
...  
Keyword(s):  
Real Time ◽  
Point Of Care ◽  
Design Rationale ◽  
Time Point
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