The Distinction between Luminance and Spatial Contrast Components in the Pattern ERG

AbstractUpregulation of retinal dopaminergic activity may be a target treatment for myopia progression. This study aimed to explore the viability of inducing changes in retinal electrical activity with short-wavelength light targeting melanopsin-expressing retinal ganglion cells (ipRGCs) passing through the optic nerve head. Fifteen healthy non-myopic or myopic young adults were recruited and underwent stimulation with blue light using a virtual reality headset device. Amplitudes and implicit times from photopic 3.0 b-wave and pattern electroretinogram (PERG) were measured at baseline and 10 and 20 min after stimulation. Relative changes were compared between non-myopes and myopes. The ERG b-wave amplitude was significantly larger 20 min after blind-spot stimulation compared to baseline (p < 0.001) and 10 min (p < 0.001) post-stimulation. PERG amplitude P50-N95 also showed a significant main effect for ‘Time after stimulation’ (p < 0.050). Implicit times showed no differences following blind-spot stimulation. PERG and b-wave changes after blind-spot stimulation were stronger in myopes than non-myopes. It is possible to induce significant changes in retinal electrical activity by stimulating ipRGCs axons at the optic nerve head with blue light. The results suggest that the changes in retinal electrical activity are located at the inner plexiform layer and are likely to involve the dopaminergic system.

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Interocular Amplitude and Latency Differences of Pattern ERG and Pattern VEP Parameters

Optometry and Vision Science ◽

10.1097/opx.0000000000000193 ◽

2014 ◽

Vol 91 (4) ◽

pp. 472-476

Author(s):

Imre Fejes ◽

Péter Balázs Kocsis ◽

György Benedek ◽

Márta Janáky

Keyword(s):

Pattern Erg ◽

Pattern Vep

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Pattern ERG as a predictor in ocular hypertensive

Asian Journal of Ophthalmology ◽

10.35119/asjoo.v15i2.215 ◽

2016 ◽

Vol 15 (2) ◽

Author(s):

Paaraj Dave ◽

Jitendra Jethani

Keyword(s):

Amplitude Ratio ◽

Corneal Thickness ◽

Visual Fields ◽

Cross Sectional Study ◽

Control Group ◽

Study Group ◽

Pattern Erg ◽

Check Size ◽

Cross Sectional ◽

The Mean

Purpose: To report the repeatability of Pattern Electrotretinogram (PERG) and its findings in ocular hypertension (OHT) and normal eyes.Methods: A cross-sectional study where PERG responses were compared between the study group comprising of 80 eyes of 80 patients with intraocular pressure (IOP)>21 mmHg and the control group with 80 eyes of 80 normal individuals (IOP≤21mmHg). The optic disc and the visual fields were normal with a visual acuity of ≥ 0.8 in both groups. PERG was recorded twice for each individual in the control group by a single operator on 2 consecutive days to assess the repeatability.Results: The mean age in the study and control groups was 50.05±10.03 and 54.8±7.66 years(p=0.44) respectively. The mean IOP was 26.55±3.9 mmHg for the study group as opposed to 14.45±2.9 mmHg for the controls (p<0.001). The central corneal thickness and the cup-disc ratio was similar between the groups (p>.05). The P50-N95 amplitude (p=0.01) and the P50 latency (p<0.001) was statistically significantly different between both the groups. The intra-class correlation coefficient (ICC) showed poor agreement for all parameters except for N35-P50 0.8 to 16 degree check size amplitude ratio (PERG ratio).Conclusion: Increase in P50 latency emerges as a new candidate for early glaucoma indicator in addition to reduction in P50-N95 amplitude. PERG parameters suffer from high test-retest variability. Deterioration in PERG recordings should be interpreted with caution. The variability is lesser for the PERG ratio which maybe more meaningful while monitoring for change over time.

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Diagnosis of protan and deutan color vision deficiencies with pattern-ERG and VEP

Colour Vision Deficiencies XII - Documenta Ophthalmologica Proceedings Series ◽

10.1007/978-94-011-0507-1_45 ◽

1995 ◽

pp. 375-380

Author(s):

Jürgen Gerling ◽

Thomas Meigen ◽

Michael Bach

Keyword(s):

Color Vision ◽

Pattern Erg ◽

Color Vision Deficiencies

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Using pattern ERG to objectively measure contrast sensitivity associated with intraocular lenses

Journal of Clinical & Experimental Ophthalmology ◽

10.4172/2155-9570-c1-071 ◽

2017 ◽

Vol 08 (06) ◽

Author(s):

Kenneth Lu

Keyword(s):

Contrast Sensitivity ◽

Intraocular Lenses ◽

Pattern Erg

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Visual Evoked Potentials and Electroretinograms

10.1093/med/9780190228484.003.0041 ◽

2017 ◽

Author(s):

Gastone G. Celesia ◽

Neal S. Peachey

Keyword(s):

Evoked Potentials ◽

Visual Evoked Potentials ◽

Visual Processing ◽

Objective Assessment ◽

Clinical Signs ◽

Simultaneous Recording ◽

Pattern Erg ◽

Pattern Vep ◽

Toxicity Of Drugs ◽

Visual Evoked

Electrophysiological testing of vision permits the objective assessment of the function of the retina, visual pathways, and cortices. This chapter covers visual evoked potentials (VEPs) and electroretinography (ERG). Flash ERG is useful in evaluating the outer retinal function and specifically helping in the diagnosis of retinal degeneration, monitoring the progress of retinal diseases, monitoring the retinal toxicity of drugs, and understanding the pathophysiology of retinal disorders. VEPs to various stimuli are useful in evaluating macular disorders, diagnosing optic neuropathies, detecting silent pathologies in the absence of other clinical signs of visual impairment, and evaluating disturbances of visual processing in degenerative diseases of the central nervous system. Simultaneous recording of pattern ERG and pattern VEP permits the differentiation between maculopathies and optic neuropathy.

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