The Lyophilic Structure-Mechanical Barrier as a Factor of Dispersion Strong Stabilization

2003 ◽  
pp. 81-90 ◽  
Author(s):  
Eugene D. Shchukin ◽  
Elena A. Amelina ◽  
Victoria N. Izmailova
Keyword(s):  
Strong Stabilization ◽  
Mechanical Barrier

Intratracheal perfluorocarbons diminish LPS-induced increase in systemic TNF-α

2008 ◽  
Vol 294 (6) ◽  
pp. L1043-L1048 ◽  
Author(s):  
Wolfram Burkhardt ◽  
Petra Koehne ◽  
Heide Wissel ◽  
Susanne Graf ◽  
Hans Proquitté ◽  
...  
Keyword(s):  
Histological Evaluation ◽  
Partial Liquid Ventilation ◽  
Liquid Ventilation ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Spontaneously Breathing ◽  
Lower Expression ◽  
Mechanical Barrier ◽  
Low Serum ◽  
Inflammatory Effect

Perfluorocarbons (PFC) reduce the production of various inflammatory cytokines, including TNF-α. The anti-inflammatory effect is not entirely understood. If anti-inflammatory properties are caused by a mechanical barrier, PFC in the alveoli should have no effect on the inflammatory response to intravenous LPS administration. To test that hypothesis, rats ( n = 31) were administered LPS intravenously and were either spontaneously breathing (Spont), conventionally ventilated (CMV), or receiving partial liquid ventilation (PLV). Serum concentration of TNF-α was measured. The pulmonary expressions of TNF-α and TNF-α receptor 1 protein and of TNF-α and ICAM-1 mRNA were determined. LPS caused a significant ( P < 0.001) increase in serum TNF-α. Serum TNF-α concentration was similar in LPS/Spont (525 ± 180 pg/ml) and LPS/CMV (504 ± 154 pg/ml) but was significantly ( P < 0.001) lower in animals of the LPS/PLV group (274 ± 101 pg/ml). Immunohistochemical data on TNF-α protein expression showed a LPS-induced increase in TNF-α and TNF-α receptor 1 expression that was diminished by partial liquid ventilation. PCR measurements revealed a lower expression of TNF-α and ICAM-1 mRNA in LPS/PLV than in LPS/CMV or LPS/Spont animals. Semiquantitative histological evaluation revealed only minor alveolar inflammation with no significant differences between the groups. Low serum TNF-α concentration in PFC-treated animals is most likely explained by a decreased production of TNF-α in the lung.

Extracellular regulation of BMP signaling: welcome to the matrix

2017 ◽  
Vol 45 (1) ◽  
pp. 173-181 ◽  
Author(s):  
Georg Sedlmeier ◽  
Jonathan P. Sleeman
Keyword(s):  
Extracellular Matrix ◽  
Physical Properties ◽  
Bone Morphogenetic Protein ◽  
Bmp Signaling ◽  
Intracellular Level ◽  
Morphogenetic Protein ◽  
The Matrix ◽  
Mechanical Barrier

Given its importance in development and homeostasis, bone morphogenetic protein (BMP) signaling is tightly regulated at the extra- and intracellular level. The extracellular matrix (ECM) was initially thought to act as a passive mechanical barrier that sequesters BMPs. However, a new understanding about how the ECM plays an instructive role in regulating BMP signaling is emerging. In this mini-review, we discuss various ways in which the biochemical and physical properties of the ECM regulate BMP signaling.

Fabrication method of lab-on-PCB devices using a microheater with a thermo-mechanical barrier

2018 ◽  
Vol 194 ◽  
pp. 31-39 ◽  
Author(s):  
Emilio Franco ◽  
Blas Salvador ◽  
Francisco Perdigones ◽  
Miguel Cabello ◽  
José Manuel Quero
Keyword(s):  
Fabrication Method ◽  
Mechanical Barrier

scholarly journals Structural Properties of G,T-Parallel Duplexes

2010 ◽  
Vol 2010 ◽  
pp. 1-11 ◽  
Author(s):  
Anna Aviñó ◽  
Elena Cubero ◽  
Raimundo Gargallo ◽  
Carlos González ◽  
Modesto Orozco ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Structural Properties ◽  
Theoretical Calculations ◽  
Md Simulations ◽  
Theoretical Studies ◽  
Duplex Structure ◽  
Strong Stabilization ◽  
The Stability ◽  
The Impact

The structure of G,T-parallel-stranded duplexes of DNA carrying similar amounts of adenine and guanine residues is studied by means of molecular dynamics (MD) simulations and UV- and CD spectroscopies. In addition the impact of the substitution of adenine by 8-aminoadenine and guanine by 8-aminoguanine is analyzed. The presence of 8-aminoadenine and 8-aminoguanine stabilizes the parallel duplex structure. Binding of these oligonucleotides to their target polypyrimidine sequences to form the corresponding G,T-parallel triplex was not observed. Instead, when unmodified parallel-stranded duplexes were mixed with their polypyrimidine target, an interstrand Watson-Crick duplex was formed. As predicted by theoretical calculations parallel-stranded duplexes carrying 8-aminopurines did not bind to their target. The preference for the parallel-duplex over the Watson-Crick antiparallel duplex is attributed to the strong stabilization of the parallel duplex produced by the 8-aminopurines. Theoretical studies show that the isomorphism of the triads is crucial for the stability of the parallel triplex.

scholarly journals Improvement of mechanical, thermal and morphostructural properties of SBS thermoplastic elastomer using kaolin and dolomite microparticles with modified surface

2020 ◽  
Author(s):  
Maria Sonmez ◽  
Mircea Juganaru ◽  
Anton Ficai ◽  
Ovidiu Oprea ◽  
Roxana Trusca ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Composite Materials ◽  
Thermoplastic Elastomer ◽  
Elemental Distribution ◽  
Sem Images ◽  
Strong Stabilization ◽  
Modified Surface ◽  
Styrene Butadiene ◽  
Dsc Curves ◽  
Thermoplastic Rubber

The aim of this paper was to assess the influence of the modification of the surface of dolomite and kaolin with SiO2 and TiO2 precursors, on the block copolymer styrene-butadiene-styrene (SBS) type thermoplastic rubber properties. These composite materials were obtained by compounding SBS with various ratio of powders. Based on the SEM images it can conclude that the powders were homogenously dispersed in to the SBS matrix. The dolomite particles can be clearly identified in the SEM images as particles of 10 micrometers. The samples obtained with modified dolomite have similar morphology. The EDS elemental distribution confirming a good corroboration between the elements of the dolomite, kaolin and titanium or silicon elements. Based on the thermal analysis according to the residual mass, the presence of 20% mineral phase can be confirmed. According to the DSC curves a strong stabilization of the composite appears, because of the presence of the mineral component. According to the physical-mechanical data all the composite materials exhibit improved mechanical properties. Additionally, the modification of the kaolin and/or dolomite bring important improvements in mechanical properties. The samples 13 and 14 exhibit high tensile and tear strength. These composites can be used for various applications, such as, for instance, soles for firefighters' footwear.

scholarly journals The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Shanshan Chen ◽  
Chi Zhang ◽  
Beihui He ◽  
Ruonan He ◽  
Li Xu ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Pathogenic Bacteria ◽  
Inflammatory Diseases ◽  
Cell Activity ◽  
Chromatin Regulation ◽  
Intestinal Diseases ◽  
Intestinal Environment ◽  
The Stability ◽  
Mechanical Barrier

lncRNA is a transcript that is more than 200 bp in length. Currently, evidence has shown that lncRNA is of great significance in cell activity, involved in epigenetics, gene transcription, chromatin regulation, etc. The existence of an intestinal mucosal mechanical barrier hinders the invasion of pathogenic bacteria and toxins, maintaining the stability of the intestinal environment. Serious destruction or dysfunction of the mechanical barrier often leads to intestinal diseases. This review first summarizes the ability of lncRNAs to regulate the intestinal mucosal mechanical barrier. We then discussed how lncRNAs participate in various intestinal diseases by regulating the intestinal mucosal mechanical barrier. Finally, we envision its potential as a new marker for diagnosing and treating intestinal inflammatory diseases.

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