Mechanisms Underlying Endocrine Disruption and Breast Cancer

2001 ◽  
pp. 119-147 ◽  
Author(s):  
E. Pluygers ◽  
A. Sadowska
Keyword(s):  
Breast Cancer ◽  
Endocrine Disruption

scholarly journals DDT, endocrine disruption and breast cancer

2015 ◽  
Vol 11 (9) ◽  
pp. 507-508 ◽  
Author(s):  
Ana M. Soto ◽  
Carlos Sonnenschein
Keyword(s):  
Breast Cancer ◽  
Endocrine Disruption

scholarly journals In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness

2019 ◽  
Author(s):  
Clarissa Wormsbaecher ◽  
Andrea R. Hindman ◽  
Alex Avendano ◽  
Marcos Cortes ◽  
Andrew Bushman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Endocrine Disruption ◽  
Early Life ◽  
Collagen Matrix ◽  
In Utero ◽  
Collagen Deposition ◽  
Matrix Density ◽  
Adult Mice

AbstractIn utero endocrine disruption is linked to increased risk of breast cancer later in life. Despite numerous studies establishing this linkage, the long-term molecular changes that predispose mammary cells to carcinogenic transformation are unknown. Several lines of evidence indicate the stroma mediates endocrine disruption following early-life (or in utero) exposure. Herein, we utilized BPA as a model of estrogenic endocrine disruption to analyze the long-term consequences in the stroma. Using RNA-seq transcriptional profiling of adult primary fibroblasts isolated from female mice exposed to BPA in utero, we identified deregulated genes associated with the extracellular matrix. Specifically, multiple collagen genes had increased expression in exposed mice. In line with the transcriptional data, collagen deposition is increased in adult BPA-exposed mice. We further demonstrate in vitro that fibroblasts exposed to BPA in utero remodel a collagen matrix, thereby decreasing permeability of the collagen matrix. These alterations to the mammary gland resulted in increased gland stiffness in the adult mice. Our data connects early life endocrine disruption to breast density. Interestingly, increased collagen deposition and gland stiffness were not observed in the developing glands of younger mice, suggesting risk factors for breast cancer continue to develop throughout life following these exposures. Finally, we assessed whether in utero exposure to two other endocrine disruptors, BPS and DES, also increase breast stiffness in adult mice. While DES increased breast stiffness, BPS did not, suggesting this BPA alternative may in fact pose less breast cancer risk than its predecessor. As breast stiffness, extracellular matrix density, and collagen deposition have been directly linked to breast cancer risk, these data mechanistically link endocrine disruptor exposures and molecular alterations to increased disease susceptibility in the gland.

Reproductive health and endocrine disruption in breast cancer care

2010 ◽  
Vol 94 (4) ◽  
pp. S103
Author(s):  
M. Sreedevi ◽  
A. Uy ◽  
E. Radeke ◽  
A. Patel ◽  
H. Zaren
Keyword(s):  
Breast Cancer ◽  
Reproductive Health ◽  
Endocrine Disruption ◽  
Cancer Care ◽  
Breast Cancer Care

Reproductive health and endocrine disruption in women with breast cancer: a pilot study

2014 ◽  
Vol 23 (2) ◽  
pp. 411-418 ◽  
Author(s):  
Ashlesha Patel ◽  
Alicia Roston ◽  
Almae Uy ◽  
Erika Radeke ◽  
Arden Roston ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pilot Study ◽  
Reproductive Health ◽  
Endocrine Disruption

scholarly journals Endocrine disruption of the epigenome: a breast cancer link

2014 ◽  
Vol 21 (2) ◽  
pp. T33-T55 ◽  
Author(s):  
Kevin C Knower ◽  
Sarah Q To ◽  
Yuet-Kin Leung ◽  
Shuk-Mei Ho ◽  
Colin D Clyne
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Endocrine Disruption ◽  
Endocrine Disrupting Chemicals ◽  
Experimental Models ◽  
Epigenetic Alterations ◽  
Early Life Exposure ◽  
Endocrine Disrupting ◽  
Heterogenous Population

The heritable component of breast cancer accounts for only a small proportion of total incidences. Environmental and lifestyle factors are therefore considered to among the major influencing components increasing breast cancer risk. Endocrine-disrupting chemicals (EDCs) are ubiquitous in the environment. The estrogenic property of EDCs has thus shown many associations between ongoing exposures and the development of endocrine-related diseases, including breast cancer. The environment consists of a heterogenous population of EDCs and despite many identified modes of action, including that of altering the epigenome, drawing definitive correlations regarding breast cancer has been a point of much discussion. In this review, we describe in detail well-characterized EDCs and their actions in the environment, their ability to disrupt mammary gland formation in animal and human experimental models and their associations with exposure and breast cancer risk. We also highlight the susceptibility of early-life exposure to each EDC to mediate epigenetic alterations, and where possible describe how these epigenome changes influence breast cancer risk.

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

Further Ultrastructural Observations on Metastatic Nodules of Human Breast Cancer

1968 ◽  
Vol 26 ◽  
pp. 224-225
Author(s):  
John L. Swedo ◽  
R. W. Talley ◽  
John H. L. Watson
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Estrogen Therapy ◽  
Specimen Preparation ◽  
Human Breast ◽  
Autophagic Vacuoles ◽  
Previous Communication ◽  
Linear Profiles ◽  
Metastatic Nodule

Since the report, which described the ultrastructure of a metastatic nodule of human breast cancer after estrogen therapy, additional ultrastructural observations, including some which are correlative with pertinent findings in the literature concerning mycoplasmas, have been recorded concerning the same subject. Specimen preparation was identical to that in.The mitochondria possessed few cristae, and were deteriorated and vacuolated. They often contained particulates and fibrous structures, sometimes arranged in spindle-shaped bundles, Fig. 1. Another apparent aberration was the occurrence, Fig. 2 (arrows) of linear profiles of what seems to be SER, which lie between layers of RER, and are often recognizably continuous with them.It was noted that the structure of the round bodies, interpreted as within autophagic vacuoles in the previous communication, and of vesicular bodies, described morphologically closely resembled those of some mycoplasmas. Specifically, they simulated or reflected the various stages of replication reported for mycoplasmas grown on solid nutrient. Based on this observation, they are referred to here as “mycoplasma-like” structures, in anticipation of confirmatory evidence from investigations now in progress.

The proliferation of breast cancer cells are inhibited by the human intrabody targeting cyclinD1

2010 ◽  
Vol 34 (8) ◽  
pp. S49-S49
Author(s):  
Lei Wang ◽  
Xun Zhou ◽  
Lihong Zhou ◽  
Yong Chen ◽  
Xun Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells

Study of the mechanism responsible for multidrug resistance in breast cancer MCF-7 cell mediated by 14-3-3σ

2010 ◽  
Vol 34 (8) ◽  
pp. S47-S47
Author(s):  
Guopei Zheng ◽  
Sisi Yi ◽  
Yafei Li ◽  
Fangren Kong ◽  
Yanhui Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Mcf 7
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