p53 Mutation in the Genesis of Metastasis

2014 ◽  
pp. 105-117 ◽  
Author(s):  
W. A. Yeudall
Keyword(s):  
P53 Mutation

THE ROLE OF THE GENETIC ABNORMALITIES, EPIGENETIC AND microRNA IN THE PROGNOSIS OF CHRONIC LYMPHOCYTIC LEUKEMIA

2018 ◽  
Vol 40 (4) ◽  
pp. 261-267 ◽  
Author(s):  
K Tari ◽  
Z Shamsi ◽  
H Reza Ghafari ◽  
A Atashi ◽  
M Shahjahani ◽  
...  
Keyword(s):  
B Cells ◽  
Chronic Lymphocytic Leukemia ◽  
Kinase Inhibitors ◽  
Bone Marrow Involvement ◽  
P53 Mutation ◽  
Lymphocytic Leukemia ◽  
Gene Promoters ◽  
Epigenetic Changes ◽  
Genetic Changes ◽  
Trisomy 12

Chronic lymphocytic leukemia (CLL) is increased proliferation of B-cells with peripheral blood and bone marrow involvement, which is usually observed in older people. Genetic mutations, epigenetic changes and miRs play a role in CLL pathogenesis. Del 11q, del l17q, del 6q, trisomy 12, p53 and IgVH mutations are the most important genetic changes in CLL. Deletion of miR-15a and miR-16a can increase bcl2 gene expression, miR-29 and miR-181 deletions decrease the expression of TCL1, and miR-146a deletion prevents tumor metastasis. Epigenetic changes such as hypo- and hypermethylation, ubiquitination, hypo- and hyperacetylation of gene promoters involved in CLL pathogenesis can also play a role in CLL. Expression of CD38 and ZAP70, presence or absence of mutation in IgVH and P53 mutation are among the factors involved in CLL prognosis. Use of monoclonal antibodies against surface markers of B-cells like anti-CD20 as well as tyrosine kinase inhibitors are the most important therapeutic approaches for CLL.

scholarly journals Stromal FAP is an independent poor prognosis marker in non-small cell lung adenocarcinoma and associated with p53 mutation

Lung Cancer ◽  
2021 ◽  
Author(s):  
Pablo Moreno-Ruiz ◽  
Sara Corvigno ◽  
Nienke C. te Grootenhuis ◽  
Linnéa La Fleur ◽  
Max Backman ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Poor Prognosis ◽  
P53 Mutation ◽  
Small Cell ◽  
Small Cell Lung ◽  
Prognosis Marker

scholarly journals UV-Radiation-Specific p53 Mutation Frequency in Normal Skin as a Predictor of Risk of Basal Cell Carcinoma

1998 ◽  
Vol 90 (7) ◽  
pp. 523-531 ◽  
Author(s):  
Allal Ouhtit ◽  
Hisayoshi Nakazawa ◽  
Hiroshi Yamasaki ◽  
Bruce K. Armstrong ◽  
Anne Kricker ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Uv Radiation ◽  
Basal Cell ◽  
Mutation Frequency ◽  
Normal Skin ◽  
P53 Mutation

scholarly journals p53 Mutation at Serine 249 and Its Gain of Function Are Highly Related to Hepatocellular Carcinoma after Smoking Exposure

2021 ◽  
pp. 1-11
Author(s):  
Huai Wang ◽  
Lu Chen ◽  
Tong Zhou ◽  
Zhongwei Zhang ◽  
Canwei Zeng
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transcriptional Activity ◽  
Direct Sequencing ◽  
Close Correlation ◽  
P53 Mutation ◽  
Gain Of Function ◽  
Reverse Transcription Pcr ◽  
Smoking Exposure ◽  
Significant Difference ◽  
Dose Response Effect

<b><i>Background:</i></b> It has been convincingly suggested that a close correlation exists between the incidence of hepatocellular carcinoma (HCC) and cigarette smoking. However, the underlying effect of smoking on HCC is not clear. <b><i>Methods:</i></b> A binary unconditional logistic regression was used for the data on a total of 300 cases and 612 controls. The approach of functional analysis of separated alleles in yeast and direct sequencing of TP53 mutations were applied to analyze the p53 status in the HCC group. The relationship between p53 mutation at serine 249 (p53-RS) and smoking was assessed. Quantitative reverse transcription PCR was employed for the evaluation to transcriptional activity of p53 and p53-RS. <b><i>Results:</i></b> Smoking was linked to the risk of HCC with an increased dose-response effect. Moreover, among subjects who did not drink, the risks of HCC were significantly increased for smokers between HCC and controls. Besides, there was an increase in the number of HCC in smokers compared to nonsmokers after exclusion of HBV and/or HCV infection. Also, a significant difference was observed in the incidence of p53-RS between smokers and nonsmokers the HCC group. Furthermore, the p53-RS transcriptional activity was significantly increased in tumor tissues. <b><i>Conclusions:</i></b> It strongly demonstrated that tobacco smoking is positively and independently associated with HCC, which may be attributed to p53-RS and its gain of function.

Atypical Angiomyolipoma of Kidney in a Patient With Tuberous Sclerosis: A Case Report With p53 Gene Mutation Analysis

2005 ◽  
Vol 129 (5) ◽  
pp. 676-679 ◽  
Author(s):  
Linglei Ma ◽  
Diane Kowalski ◽  
Khurram Javed ◽  
Pei Hui
Keyword(s):  
Tuberous Sclerosis ◽  
P53 Gene ◽  
Epithelioid Cell ◽  
P53 Mutation ◽  
P53 Gene Mutation ◽  
Perivascular Epithelioid Cell ◽  
The Family ◽  
P53 Immunoreactivity ◽  
Gene Mutation Analysis ◽  
Hmb 45

Abstract Angiomyolipoma (AML) is the most common benign mesenchymal tumor of the kidney. It belongs to the family of perivascular epithelioid cell tumors and is typically composed of blood vessels, adipose tissue, and smooth muscle– like cells, which are characteristically positive for HMB-45. Results of recent studies suggest that p53 mutation may play an important role in AML progression. Here, we describe a locally destructive renal AML in a patient with tuberous sclerosis. The tumor consisted of mostly epithelioid cells with marked nuclear pleomorphism and frequent mitoses and was positive for HMB-45. The diagnosis of atypical epithelioid AML was made. Codon alteration in the p53 gene was not detected, despite focal p53 immunoreactivity and single nucleotide polymorphism at exon 6. Our finding indicates no definite link between p53 abnormalities and the atypical appearance of AML. To the best of our knowledge, this is the second renal AML case investigated for p53 mutations.

scholarly journals Defective apoptosis and tumorigenesis: role of p53 mutation and Fas/FasL system dysregulation

10.4081/1680 ◽  
2010 ◽  
Vol 46 (3) ◽  
pp. 199 ◽  
Author(s):  
F Cappello ◽  
M Bellafiore ◽  
A Palma ◽  
F Bucchieri
Keyword(s):  
P53 Mutation

IARC p53 mutation database: A relational database to compile and analyze p53 mutations in human tumors and cell lines

1999 ◽  
Vol 14 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Tina Hernandez-Boussard ◽  
Patricia Rodriguez-Tome ◽  
Ruggero Montesano ◽  
Pierre Hainaut
Keyword(s):  
Cell Lines ◽  
Relational Database ◽  
P53 Mutation ◽  
Human Tumors ◽  
P53 Mutations ◽  
Mutation Database
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