Changes in Social Behavior Associated with Alzheimer’s Disease-Related Aβ Pathology

2016 ◽  
pp. 253-265
Author(s):  
Neha Mishra ◽  
Rameshwar Singh ◽  
Deepak Sharma
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Social Behavior

P4-226: SOCIAL BEHAVIOR OF THE TRIPLE-TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_29) ◽  
pp. P1529-P1529
Author(s):  
Brittany A. Sulkowski ◽  
Benjamin V. Rohr ◽  
John F. Kasra ◽  
Craige C. Wrenn
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Social Behavior ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Triple Transgenic Mouse

P.074 The effects of positive and negative modulators of alpha5 GABAA receptors on social behavior in 5xFAD model of Alzheimer's disease

2020 ◽  
Vol 40 ◽  
pp. S47-S48
Author(s):  
J. Arandjelovic ◽  
A. Santrac ◽  
B. Batinic ◽  
V. Stevanovic ◽  
L. Todorovic ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Social Behavior ◽  
Gabaa Receptors ◽  
Model Of Alzheimer’S Disease

Using a second-person approach to identify disease-specific profiles of social behavior in frontotemporal dementia and Alzheimer's disease

Cortex ◽  
2020 ◽  
Vol 133 ◽  
pp. 236-246
Author(s):  
Mandy Visser ◽  
Stephanie Wong ◽  
Simone Simonetti ◽  
Jessica L. Hazelton ◽  
Emma Devenney ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Social Behavior ◽  
Frontotemporal Dementia ◽  
Second Person ◽  
Disease Specific

Dementia 1: Defining Dementia, Alzheimer’s Disease and Frontotemporal Dementia (DRAFT)

2018 ◽  
Author(s):  
Tamara Kaplan ◽  
Tracey Milligan
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Social Behavior ◽  
Frontotemporal Dementia ◽  
Neurofibrillary Tangles ◽  
Repetitive Behaviors ◽  
Behavioral Changes ◽  
Cognitive Domains ◽  
Pathologic Features ◽  
Visuospatial Processing

The video in this chapter explores dementia, and focuses on definitions of dementia, Alzheimer’s disease and Frontotemporal Dementia. Dementia is defined as a cognitive decline in one or more cognitive domains including memory, language, attention, visuospatial processing and social behavior. Two hallmark pathologic features of Alzheimer’s disease (AD) are plaques, which are formed from amyloid and neurofibrillary tangles, which involve tau, whereas symptoms of Frontotemporal Dementia (FTD) may include behavioral changes, apathy and disinhibition and ritualistic or repetitive behaviors. Language may also be affected, and this can be a presenting symptom.

Cognitive control constrains memory attributions

2019 ◽  
Vol 42 ◽  
Author(s):  
Colleen M. Kelley ◽  
Larry L. Jacoby
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Control

Abstract Cognitive control constrains retrieval processing and so restricts what comes to mind as input to the attribution system. We review evidence that older adults, patients with Alzheimer's disease, and people with traumatic brain injury exert less cognitive control during retrieval, and so are susceptible to memory misattributions in the form of dramatic levels of false remembering.

Formation of paired helical filaments in Alzheimer's disease

1984 ◽  
Vol 42 ◽  
pp. 302-303
Author(s):  
J. Metuzals ◽  
D. F. Clapin ◽  
V. Montpetit
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontal Lobe ◽  
Giant Axon ◽  
Paired Helical Filaments ◽  
Normal Brain ◽  
Protein Assemblies ◽  
Electron Microscopic ◽  
Helical Symmetry ◽  
Structural Levels

Information on the conformation of paired helical filaments (PHF) and the neurofilamentous (NF) network is essential for an understanding of the mechanisms involved in the formation of the primary lesions of Alzheimer's disease (AD): tangles and plaques. The structural and chemical relationships between the NF and the PHF have to be clarified in order to discover the etiological factors of this disease. We are investigating by stereo electron microscopic and biochemical techniques frontal lobe biopsies from patients with AD and squid giant axon preparations. The helical nature of the lesion in AD is related to pathological alterations of basic properties of the nervous system due to the helical symmetry that exists at all hierarchic structural levels in the normal brain. Because of this helical symmetry of NF protein assemblies and PHF, the employment of structure reconstruction techniques to determine the conformation, particularly the handedness of these structures, is most promising. Figs. 1-3 are frontal lobe biopsies.

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