Probable Role of Non-exosomal Extracellular Vesicles in Colorectal Cancer Metastasis to Kidney: An In Vitro Cell Line Based Study and Image Analysis

ICTMI 2017 ◽  
2019 ◽  
pp. 163-174
Author(s):  
Aviral Kumar ◽  
Reetoja Nag ◽  
Satyakam Mishra ◽  
Bandaru Ramakrishna ◽  
V. V. R. Sai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Image Analysis ◽  
Cell Line ◽  
Extracellular Vesicles ◽  
Cancer Metastasis ◽  
Colorectal Cancer Metastasis ◽  
Probable Role

Examining the Role of the MACC1 Gene in Colorectal Cancer Metastasis

2021 ◽  
pp. 327-352
Author(s):  
Aparna S. Narayan ◽  
Jayshree Nellore ◽  
Valli C. Nachiyar ◽  
Sujatha Peela
Keyword(s):  
Colorectal Cancer ◽  
Cancer Metastasis ◽  
Colorectal Cancer Metastasis

scholarly journals The distinct role of strand-specific miR-514b-3p and miR-514b-5p in colorectal cancer metastasis

2018 ◽  
Vol 9 (6) ◽  
Author(s):  
Lin-Lin Ren ◽  
Ting-Ting Yan ◽  
Chao-Qin Shen ◽  
Jia-Yin Tang ◽  
Xuan Kong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Metastasis ◽  
Colorectal Cancer Metastasis ◽  
Distinct Role

Abstract 1558: The critical role of lymph node stromal cell-derived microvesicles in colorectal cancer metastasis

2016 ◽  
Author(s):  
Xin Zhang ◽  
Ryan Sullivan ◽  
Nathan Hite ◽  
Grace Maresh ◽  
Linh Hellmers ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Stromal Cell ◽  
Cancer Metastasis ◽  
Critical Role ◽  
Colorectal Cancer Metastasis

scholarly journals Novel Biomarker Candidates for Colorectal Cancer Metastasis: A Meta-analysis of In Vitro Studies

2016 ◽  
Vol 15s4 ◽  
pp. CIN.S40301
Author(s):  
Nguyen Phuoc Long ◽  
Wun Jun Lee ◽  
Nguyen Truong Huy ◽  
Seul Ji Lee ◽  
Jeong Hill Park ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microarray Data ◽  
Cancer Metastasis ◽  
Meta Analysis ◽  
Data Sets ◽  
Proteomic Data ◽  
Colorectal Cancer Metastasis ◽  
Microarray Studies ◽  
Potential Biomarkers

Colorectal cancer (CRC) is one of the most common and lethal cancers. Although numerous studies have evaluated potential biomarkers for early diagnosis, current biomarkers have failed to reach an acceptable level of accuracy for distant metastasis. In this paper, we performed a gene set meta-analysis of in vitro microarray studies and combined the results from this study with previously published proteomic data to validate and suggest prognostic candidates for CRC metastasis. Two microarray data sets included found 21 significant genes. Of these significant genes, ALDOA, IL8 (CXCL8), and PARP4 had strong potential as prognostic candidates. LAMB2, MCM7, CXCL23A, SERPINA3, ABCA3, ALDH3A2, and POLR2I also have potential. Other candidates were more controversial, possibly because of the biologic heterogeneity of tumor cells, which is a major obstacle to predicting metastasis. In conclusion, we demonstrated a meta-analysis approach and successfully suggested ten biomarker candidates for future investigation.

scholarly journals PLAGL2 promotes epithelial–mesenchymal transition and mediates colorectal cancer metastasis via β-catenin-dependent regulation of ZEB1

2019 ◽  
Vol 122 (4) ◽  
pp. 578-589
Author(s):  
Liang Wu ◽  
Zili Zhou ◽  
Shengbo Han ◽  
Jinhuang Chen ◽  
Zhengyi Liu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Metastasis ◽  
Nuclear Translocation ◽  
Epithelial Mesenchymal Transition ◽  
Malignant Tumours ◽  
Mesenchymal Transition ◽  
Exact Function ◽  
Colorectal Cancer Metastasis

Abstract Background We previously demonstrated that the pleomorphic adenoma gene like-2 (PLAGL2) is involved in the pathogenesis of Hirschsprung disease. Enhanced PLAGL2 expression was observed in several malignant tumours. However, the exact function of PLAGL2 and its underlying mechanism in colorectal cancer (CRC) remain largely unknown. Methods Immunohistochemical analysis of PLAGL2 was performed. A series of in vitro and in vivo experiments were conducted to reveal the role of PLAGL2 in the progression of CRC. Results Enhanced PLAGL2 expression was significantly associated with EMT-related proteins in CRC. The data revealed that PLAGL2 promotes CRC cell proliferation, migration, invasion and EMT both in vitro and in vivo. Mechanistically, PLAGL2 promoted the expression of ZEB1. PLAGL2 enhanced the expression and nuclear translocation of β-catenin by decreasing its phosphorylation. The depletion of β-catenin neutralised the regulation of ZEB1 that was caused by enhanced PLAGL2 expression. The small-molecule inhibitor PNU-74654, also impaired the enhancement of ZEB1 that resulted from the modified PLAGL2 expression. The depletion of ZEB1 could block the biological function of PLAGL2 in CRC cells. Conclusions Collectively, our findings suggest that PLAGL2 mediates EMT to promote colorectal cancer metastasis via β-catenin-dependent regulation of ZEB1.

scholarly journals Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis

Oncogene ◽  
2017 ◽  
Vol 36 (22) ◽  
pp. 3104-3118 ◽  
Author(s):  
E Agarwal ◽  
C M Robb ◽  
L M Smith ◽  
M G Brattain ◽  
J Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Metastasis ◽  
Metastasis Suppressor ◽  
Colorectal Cancer Metastasis ◽  
Metastasis Suppressor 1
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