Mitochondrial Metabolism in Cancer. A Tangled Topic. Which Role for Proteomics?

2019 ◽  
pp. 1-16
Author(s):  
Patrizia Bottoni ◽  
Roberto Scatena
Keyword(s):  
Mitochondrial Metabolism

Exenatide Treatment Improves Mitochondrial Metabolism and Hepatic Insulin Sensitivity in Mice with Nonalcoholic Steatohepatitis (NASH)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1846-P
Author(s):  
SRILAXMI KALAVALAPALLI ◽  
FERNANDO BRIL ◽  
ARIANA VERGARA ◽  
NISHANTH SUNNY ◽  
KENNETH CUSI
Keyword(s):  
Insulin Sensitivity ◽  
Nonalcoholic Steatohepatitis ◽  
Mitochondrial Metabolism ◽  
Hepatic Insulin Sensitivity

288-LB: Effects of the Hepatic Mitochondrial Calcium Uniporter on Hepatic Gluconeogenesis and Mitochondrial Metabolism in Awake Mice

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 288-LB
Author(s):  
JI EUN LEE ◽  
LEIGH GOEDEKE ◽  
YE ZHANG ◽  
RACHEL J. PERRY ◽  
RUSSELL GOODMAN ◽  
...  
Keyword(s):  
Mitochondrial Metabolism ◽  
Mitochondrial Calcium ◽  
Hepatic Gluconeogenesis ◽  
Mitochondrial Calcium Uniporter ◽  
Calcium Uniporter

Mitochondrial metabolism, reactive oxygen species, and macrophage function-fishing for insights

2014 ◽  
Vol 92 (11) ◽  
pp. 1119-1128 ◽  
Author(s):  
Christopher J. Hall ◽  
Leslie E. Sanderson ◽  
Kathryn E. Crosier ◽  
Philip S. Crosier
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Mitochondrial Metabolism ◽  
Oxygen Species ◽  
Macrophage Function

scholarly journals An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism

Cell Reports ◽  
2021 ◽  
Vol 34 (5) ◽  
pp. 108723 ◽  
Author(s):  
Pedro Gonzalez-Menendez ◽  
Manuela Romano ◽  
Hongxia Yan ◽  
Ruhi Deshmukh ◽  
Julien Papoin ◽  
...  
Keyword(s):  
Vitamin C ◽  
Mitochondrial Metabolism ◽  
Erythroid Development

scholarly journals Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism

2021 ◽  
pp. 100929
Author(s):  
Yuanyuan Huang ◽  
Jianlin Lu ◽  
Li Zhan ◽  
Ming Wang ◽  
Ronghua Shi ◽  
...  
Keyword(s):  
Mitochondrial Metabolism

scholarly journals Environmentally Relevant Mixture of Pesticides Affect Mobility and DNA Integrity of Early Life Stages of Rainbow Trout (Oncorhynchus mykiss)

Toxics ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 174
Author(s):  
Shannon Weeks Santos ◽  
Jérôme Cachot ◽  
Bettie Cormier ◽  
Nicolas Mazzella ◽  
Pierre-Yves Gourves ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Rainbow Trout ◽  
Oncorhynchus Mykiss ◽  
Protein Carbonyl ◽  
Swimming Activity ◽  
Mitochondrial Metabolism ◽  
Pesticide Mixture ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Mixture Concentration

The aim of this study was to analyze the impact of three concentrations of a pesticide mixture on the first development stages of rainbow trout (Oncorhynchus mykiss). The mixture was made up of three commonly used pesticides in viticulture: glyphosate (GLY), chlorpyrifos (CPF) and copper sulfate (Cu). Eyed stage embryos were exposed for 3 weeks to three concentrations of the pesticide mixture. Lethal and sub-lethal effects were assessed through a number of phenotypic and molecular endpoints including survival, hatching delay, hatching success, biometry, swimming activity, DNA damage (Comet assay), lipid peroxidation (TBARS), protein carbonyl content and gene expression. Ten target genes involved in antioxidant defenses, DNA repair, mitochondrial metabolism and apoptosis were analyzed using real-time RT-qPCR. No significant increase of mortality, half-hatch, growth defects, TBARS and protein carbonyl contents were observed whatever the pesticide mixture concentration. In contrast, DNA damage and swimming activity were significantly more elevated at the highest pesticide mixture concentration. Gene transcription was up-regulated for genes involved in detoxification (gst and mt1), DNA repair (ogg1), mitochondrial metabolism (cox1 and 12S), and cholinergic system (ache). This study highlighted the induction of adaptive molecular and behavioral responses of rainbow trout larvae when exposed to environmentally realistic concentrations of a mixture of pesticides.

scholarly journals Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yawei Wang ◽  
Binlin Tang ◽  
Lei Long ◽  
Peng Luo ◽  
Wei Xiang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Oxidative Phosphorylation ◽  
Near Infrared ◽  
Mitochondrial Metabolism ◽  
Diet Induced Obesity ◽  
Adipose Tissue Macrophages ◽  
Inflammatory Activation ◽  
Treatment Of Obesity ◽  
Pharmaceutical Agents

AbstractPro-inflammatory activation of adipose tissue macrophages (ATMs) is causally linked to obesity and obesity-associated disorders. A number of studies have demonstrated the crucial role of mitochondrial metabolism in macrophage activation. However, there is a lack of pharmaceutical agents to target the mitochondrial metabolism of ATMs for the treatment of obesity-related diseases. Here, we characterize a near-infrared fluorophore (IR-61) that preferentially accumulates in the mitochondria of ATMs and has a therapeutic effect on diet-induced obesity as well as obesity-associated insulin resistance and fatty liver. IR-61 inhibits the classical activation of ATMs by increasing mitochondrial complex levels and oxidative phosphorylation via the ROS/Akt/Acly pathway. Taken together, our findings indicate that specific enhancement of ATMs oxidative phosphorylation improves chronic inflammation and obesity-related disorders. IR-61 might be an anti-inflammatory agent useful for the treatment of obesity-related diseases by targeting the mitochondria of ATMs.

Mitochondrial metabolism and calcium homeostasis in the development of NAFLD leading to hepatocellular carcinoma

Mitochondrion ◽  
2021 ◽  
Vol 58 ◽  
pp. 24-37
Author(s):  
Snigdha Bhowmick ◽  
Vandana Singh ◽  
Sandipan Jash ◽  
Megha Lal ◽  
Soumya Sinha Roy
Keyword(s):  
Hepatocellular Carcinoma ◽  
Calcium Homeostasis ◽  
Mitochondrial Metabolism
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