Oxidant-Dependent and Oxidant-Independent Proangiogenic and Vasomotor Signaling in Coronary Vascular Endothelium

2019 ◽  
pp. 23-61 ◽  
Author(s):  
Sarah Aldosari ◽  
Maan Awad ◽  
May Z. Gao ◽  
Isabella G. McCormack ◽  
Frank W. Sellke ◽  
...  
Keyword(s):  
Vascular Endothelium

Polyphenolic compounds from Clusiaceae plants modulating angiogenesis and vascular endothelium

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
A Lavaud ◽  
R Soletti ◽  
P Richomme ◽  
R Andriantsitohaina ◽  
D Guilet
Keyword(s):  
Vascular Endothelium ◽  
Polyphenolic Compounds

Ultrastructural Changes of the Tissue Thromboplastin after Intravenous Injection in Rabbits

1978 ◽  
Vol 39 (01) ◽  
pp. 201-209 ◽  
Author(s):  
Hiroshi Hasegawa ◽  
Hiroshi Nagata ◽  
Makoto Murao
Keyword(s):  
Intravenous Injection ◽  
Vascular Endothelium ◽  
Model Experiment ◽  
Venous Return ◽  
Ultrastructural Changes ◽  
Membrane Structures ◽  
Tissue Thromboplastin ◽  
Short Time ◽  
Sheet Membrane

SummaryAttempts were made to demonstrate ultrastructural changes of the tissue thromboplastin after intravenous injection, as a model experiment on the pulmonary microthrombi formation induced by the tissue thromboplastin circulating from venous return.Concentrically arranged membrane structures of the injected thromboplastin disappeared in extremely short time after the injection of the thromboplastin in rabbits. The long sheet membrane of the injected thromboplastin was frequently seen as adhered to the vascular endothelium or to the surface of blood corpuscles. Furthermore, fibrin fibres were formed in contact with the long sheet membrane of the thromboplastin. Membrane structures were not found anywhere in the control rabbits.

Elevated Fibronectin Plasma Levels in Diabetes Mellitus Are Expression of Increased Synthesis and Release by Vascular Endothelium

1989 ◽  
Vol 61 (01) ◽  
pp. 150-151 ◽  
Author(s):  
R Musso ◽  
A Longo ◽  
R R Cacciola ◽  
A Lombardo ◽  
R Giustolisi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vascular Endothelium ◽  
Plasma Levels

The Use of Desmopressin Acetate (DDAVP) as a Test of the Fibrinolytic Capacity of Patients – Analysis of Responders and Non-Responders

1982 ◽  
Vol 48 (02) ◽  
pp. 156-161 ◽  
Author(s):  
E J P Brommer ◽  
M M Barrett-Bergshoeff ◽  
R A Allen ◽  
I Schicht ◽  
R M Bertina ◽  
...  
Keyword(s):  
Renal Insufficiency ◽  
Plasminogen Activator ◽  
Vascular Endothelium ◽  
Fibrinolytic Activity ◽  
Baseline Level ◽  
Poor Response ◽  
Facial Flushing ◽  
Spontaneous Thrombosis ◽  
Type Iv ◽  
Fibrinolytic Capacity

SummaryIntravenous infusion of desmopressin (DDAVP, 0.4 μg/kg b.w. in 12’) causes an increase in the level of extrinsic plasminogen activator, measured in plasma euglobulin fractions with added C1-inactivator on fibrin plates. A poor response or no response at all was elicited in two out of 21 patients with spontaneous thrombosis, 18/38 with hyperlipoproteinaemia and 10/14 with terminal renal insufficiency requiring haemodialysis.Haemodilution during the first 30’ after starting the DDAVP-infusion occurred both in responders and in non-responders; so did haemodynamic reactions: increase in heart rate, drop in diastolic blood pressure, facial flushing. The rise of fibrinolytic activity was shown not to be associated with decreased hepatic blood flow. Normal factor VIII-rises in “non-responders” indicate the responsiveness of the receptive organs, including the hypothalamus, to DDAVP.Despite a normal baseline level of fibrinolytic activity in the blood, as occurs for instance in terminal renal insufficiency, the vascular endothelium may be refractory to stimulation. In some patients, especially in type IV hyperlipoproteinaemia, a selective defect of the release of plasminogen activator is postulated. In subjects with low fibrinolytic activity at rest, as observed in spontaneous thromboembolism and in hypertriglyceridaemia, the failure to release plasminogen activator upon stimulation with DDAVP might be a consequence of an impairment of synthesis as well.

The Endothelial Glycocalyx Contributes to the Anchorage of von Willebrand Factor Fibers to the Vascular Endothelium

2019 ◽  
Author(s):  
T. Kalagara ◽  
T. Moutsis ◽  
Y. Yang ◽  
K.I. Pappelbaum ◽  
A. Farken ◽  
...  
Keyword(s):  
Von Willebrand Factor ◽  
Vascular Endothelium ◽  
Endothelial Glycocalyx ◽  
Von Willebrand ◽  
Willebrand Factor

Vascular endothelium of newborn descendants with smoking parents

2016 ◽  
Vol 78 (6) ◽  
pp. 56-59
Author(s):  
G.I. Gubina-Vakulyk ◽  
◽  
T.V. Gorbach ◽  
V.Yu. Yunusov ◽  
E.M. Lukyanova ◽  
...  
Keyword(s):  
Vascular Endothelium

A New Concept of the Pathogenesis of Retinopathy of Prematurity

2020 ◽  
pp. 5-12
Author(s):  
E.I. Sidorenko ◽  
Keyword(s):  
Growth Factors ◽  
Retinopathy Of Prematurity ◽  
Vascular Endothelium ◽  
Retinal Vessels ◽  
Protective Mechanisms ◽  
Preclinical Stage ◽  
Circulatory Hypoxia ◽  
Preclinical Phase ◽  
Vasculogenesis And Angiogenesis ◽  
Vascular Autoregulation

The lecture provides a detailed description of the development of retinal vessels, vasculogenesis and angiogenesis. The cascade of protective mechanisms of the organism of the system of combating hyperoxia, the system of combating circulatory hypoxia and the key growth factors of the vascular endothelium during angiogenesis are shown. The pathogenesis of retinopathy of prematurity is described and the first phase of ROP development is analyzed in detail, the reasons for the delay in the maturation of vascular autoregulation are explained. The author proposed to distinguish the first preclinical phase in the ROP classification. In contrast to the modern concentration of attention of ophthalmologists on the active and cicatricial stages, the author proposes to pay special attention to the study of the preclinical stage of ROP, where its pathogenesis is formed.

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