Immunohistochemical localization of microtubule-associated proteins in the nervous system of the small intestine of guinea pig

1989 ◽  
Vol 255 (2) ◽  
Author(s):  
Hiromu Murofushi ◽  
Michiko Suzuki ◽  
Hikoichi Sakai ◽  
Shigeru Kobayashi
Keyword(s):  
Nervous System ◽  
Small Intestine ◽  
Guinea Pig ◽  
Immunohistochemical Localization ◽  
Microtubule Associated Proteins ◽  
Associated Proteins

Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig stomach and small intestine

2003 ◽  
Vol 459 (1) ◽  
pp. 27-39 ◽  
Author(s):  
Sumei Liu ◽  
Hong-Zhen Hu ◽  
Chuanyun Gao ◽  
Na Gao ◽  
Guodu Wang ◽  
...  
Keyword(s):  
Nervous System ◽  
Small Intestine ◽  
Guinea Pig ◽  
Enteric Nervous System ◽  
Cysteinyl Leukotrienes ◽  
Guinea Pig Stomach

scholarly journals Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine

2014 ◽  
Vol 307 (7) ◽  
pp. G719-G731 ◽  
Author(s):  
Guo-Du Wang ◽  
Xi-Yu Wang ◽  
Sumei Liu ◽  
Meihua Qu ◽  
Yun Xia ◽  
...  
Keyword(s):  
Nervous System ◽  
Mast Cell ◽  
Small Intestine ◽  
Electrical Stimulation ◽  
Mast Cells ◽  
Guinea Pig ◽  
Mast Cell Protease ◽  
Human Small Intestine ◽  
Neurokinin 1 ◽  
Stimulation Of

Mast cells express the substance P (SP) neurokinin 1 receptor and the calcitonin gene-related peptide (CGRP) receptor in guinea pig and human small intestine. Enzyme-linked immunoassay showed that activation of intramural afferents by antidromic electrical stimulation or by capsaicin released SP and CGRP from human and guinea pig intestinal segments. Electrical stimulation of the afferents evoked slow excitatory postsynaptic potentials (EPSPs) in the enteric nervous system. The slow EPSPs were mediated by tachykinin neurokinin 1 and CGRP receptors. Capsaicin evoked slow EPSP-like responses that were suppressed by antagonists for protease-activated receptor 2. Afferent stimulation evoked slow EPSP-like excitation that was suppressed by mast cell-stabilizing drugs. Histamine and mast cell protease II were released by 1) exposure to SP or CGRP, 2) capsaicin, 3) compound 48/80, 4) elevation of mast cell Ca2+ by ionophore A23187, and 5) antidromic electrical stimulation of afferents. The mast cell stabilizers cromolyn and doxantrazole suppressed release of protease II and histamine when evoked by SP, CGRP, capsaicin, A23187, electrical stimulation of afferents, or compound 48/80. Neural blockade by tetrodotoxin prevented mast cell protease II release in response to antidromic electrical stimulation of mesenteric afferents. The results support a hypothesis that afferent innervation of enteric mast cells releases histamine and mast cell protease II, both of which are known to act in a diffuse paracrine manner to influence the behavior of enteric nervous system neurons and to elevate the sensitivity of spinal afferent terminals.

P2X7 receptors in the enteric nervous system of guinea-pig small intestine

2001 ◽  
Vol 440 (3) ◽  
pp. 299-310 ◽  
Author(s):  
Hong-Zhen Hu ◽  
Na Gao ◽  
Zhong Lin ◽  
Chuanyun Gao ◽  
Sumei Liu ◽  
...  
Keyword(s):  
Nervous System ◽  
Small Intestine ◽  
Guinea Pig ◽  
Enteric Nervous System ◽  
P2x7 Receptors

scholarly journals Exploring neurodegeneration at the atomic level

2018 ◽  
Vol 40 (5) ◽  
pp. 9-11
Author(s):  
Adam Tozer
Keyword(s):  
Amino Acids ◽  
Central Nervous System ◽  
Nervous System ◽  
Atomic Level ◽  
Tau Proteins ◽  
Microtubule Associated Proteins ◽  
Associated Proteins ◽  
The Central Nervous System ◽  
The Brain ◽  
Cell Maintenance

Tau proteins are microtubule-associated proteins essential for the correct functioning of neurons. This small family of proteins, 352–441 amino acids in length, are abundant in the brain and exist to stabilize microtubules in neurons and glia (non-neuronal cells of the central nervous system) to ensure correct trafficking of cellular cargo and cell maintenance.

scholarly journals MAP6 is an intraluminal protein that induces neuronal microtubules to coil

2020 ◽  
Vol 6 (14) ◽  
pp. eaaz4344 ◽  
Author(s):  
Camille Cuveillier ◽  
Julie Delaroche ◽  
Maxime Seggio ◽  
Sylvie Gory-Fauré ◽  
Christophe Bosc ◽  
...  
Keyword(s):  
Nervous System ◽  
Mechanical Stress ◽  
Microtubule Associated Proteins ◽  
Left Handed ◽  
Neuronal Processes ◽  
Associated Proteins ◽  
The Face ◽  
Cold Stability

Neuronal activities depend heavily on microtubules, which shape neuronal processes and transport myriad molecules within them. Although constantly remodeled through growth and shrinkage events, neuronal microtubules must be sufficiently stable to maintain nervous system wiring. This stability is somehow maintained by various microtubule-associated proteins (MAPs), but little is known about how these proteins work. Here, we show that MAP6, previously known to confer cold stability to microtubules, promotes growth. More unexpectedly, MAP6 localizes in the lumen of microtubules, induces the microtubules to coil into a left-handed helix, and forms apertures in the lattice, likely to relieve mechanical stress. These features have not been seen in microtubules before and could play roles in maintaining axonal width or providing flexibility in the face of compressive forces during development.

scholarly journals The Light Chains of Microtubule-Associated Proteins MAP1A and MAP1B Interact with α1-Syntrophin in the Central and Peripheral Nervous System

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49722 ◽  
Author(s):  
Heike Fuhrmann-Stroissnigg ◽  
Rainer Noiges ◽  
Luise Descovich ◽  
Irmgard Fischer ◽  
Douglas E. Albrecht ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Light Chains ◽  
Microtubule Associated Proteins ◽  
Associated Proteins
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