The influence of chemotherapy on the distribution of 57Co-bleomycin in chemically induced squamous cell carcinoma of mouse skin

1979 ◽  
Vol 4 (1) ◽  
Author(s):  
T. Pertynski ◽  
G. Reznik ◽  
P. Mari� ◽  
M.B. Ketkar ◽  
H. Haindl ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mouse Skin ◽  
Chemically Induced

scholarly journals Loss of epidermal MCPIP1 is associated with aggressive squamous cell carcinoma

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Weronika Szukala ◽  
Agata Lichawska-Cieslar ◽  
Roza Pietrzycka ◽  
Maria Kulecka ◽  
Izabela Rumienczyk ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Precancerous Lesions ◽  
Mouse Skin ◽  
Normal Human Skin ◽  
Chemically Induced

Abstract Background Squamous cell carcinoma (SCC) of the skin is a common form of nonmelanoma skin cancer. Monocyte chemotactic protein 1-induced protein 1 (MCPIP1), also called Regnase-1, is an RNase with anti-inflammatory properties. In normal human skin, its expression is predominantly restricted to the suprabasal epidermis. The main aim of this study was to investigate whether MCPIP1 is involved in the pathogenesis of SCC. Methods We analyzed the distribution of MCPIP1 in skin biopsies of patients with actinic keratoses (AKs) and SCCs. To explore the mechanisms by which MCPIP1 may modulate tumorigenesis in vivo, we established a mouse model of chemically induced carcinogenesis. Results Skin expression of MCPIP1 changed during the transformation of precancerous lesions into cutaneous SCC. MCPIP1 immunoreactivity was high in the thickened area of the AK epidermis but was predominantly restricted to keratin pearls in fully developed SCC lesions. Accelerated development of chemically induced skin tumors was observed in mice with loss of epidermal MCPIP1 (Mcpip1eKO). Papillomas that developed in Mcpip1eKO mouse skin were larger and characterized by elevated expression of markers typical of keratinocyte proliferation and tumor angiogenesis. This phenotype was correlated with enhanced expression of IL-6, IL-33 and transforming growth factor-beta (TGF-β). Moreover, our results demonstrated that in keratinocytes, the RNase MCPIP1 is essential for the negative regulation of genes encoding SCC antigens and matrix metallopeptidase 9. Conclusions Overall, our results provide a mechanistic understanding of how MCPIP1 contributes to the development of epidermoid carcinoma.

scholarly journals Erratum: Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma

2016 ◽  
Vol 22 (2) ◽  
pp. 217-217 ◽  
Author(s):  
Dany Nassar ◽  
Mathilde Latil ◽  
Bram Boeckx ◽  
Diether Lambrechts ◽  
Cédric Blanpain
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mouse Skin ◽  
Skin Squamous Cell Carcinoma ◽  
Genomic Landscape

scholarly journals Effects of heme oxygenase-1 on induction and development of chemically induced squamous cell carcinoma in mice

2011 ◽  
Vol 51 (9) ◽  
pp. 1717-1726 ◽  
Author(s):  
Halina Was ◽  
Malgorzata Sokolowska ◽  
Aleksandra Sierpniowska ◽  
Paweł Dominik ◽  
Klaudia Skrzypek ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Heme Oxygenase ◽  
Squamous Cell ◽  
Heme Oxygenase 1 ◽  
Chemically Induced

scholarly journals Efficacy of quercetin against chemically induced murine oral squamous cell carcinoma

2015 ◽  
Vol 10 (4) ◽  
pp. 2432-2438 ◽  
Author(s):  
DANIEL DROGUETT ◽  
CHRISTIAN CASTILLO ◽  
ELBA LEIVA ◽  
CRISTINA THEODULOZ ◽  
GUILLERMO SCHMEDA-HIRSCHMANN ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Chemically Induced

scholarly journals Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma

2017 ◽  
Vol 49 (11) ◽  
pp. 1624-1632 ◽  
Author(s):  
Phillips Y Huang ◽  
Eve Kandyba ◽  
Arnaud Jabouille ◽  
Jonas Sjolund ◽  
Atul Kumar ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mouse Skin ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Skin Squamous Cell Carcinoma

Chemopreventive potential of the pentane-based fraction of wild carrot oil against chemically-induced squamous cell carcinoma

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
W Shebaby ◽  
G Daher ◽  
R Taleb ◽  
H Daaboul ◽  
M El Sibai ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Chemically Induced ◽  
Wild Carrot

scholarly journals A Chemically Induced Model for Squamous Cell Carcinoma of the Lung in Mice

2004 ◽  
Vol 64 (5) ◽  
pp. 1647-1654 ◽  
Author(s):  
Yian Wang ◽  
Zhongqiu Zhang ◽  
Ying Yan ◽  
William J. Lemon ◽  
Marie LaRegina ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Chemically Induced

scholarly journals miR-22 promotes stem cell traits via activating Wnt/β-catenin signaling in cutaneous squamous cell carcinoma

Oncogene ◽  
2021 ◽  
Author(s):  
Shukai Yuan ◽  
Peitao Zhang ◽  
Liqi Wen ◽  
Shikai Jia ◽  
Yufan Wu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cancer Metastasis ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Chemotherapy Sensitivity ◽  
Oncogenic Pathways ◽  
Chemically Induced ◽  
Xenograft Mice

AbstractEmerging evidence suggests that the cancer stem cells (CSCs) are key culprits of cancer metastasis and drug resistance. Understanding mechanisms regulating the critical oncogenic pathways and CSCs function could reveal new diagnostic and therapeutic strategies. We now report that miR-22, a miRNA critical for hair follicle stem/progenitor cell differentiation, promotes tumor initiation, progression, and metastasis by maintaining Wnt/β-catenin signaling and CSCs function. Mechanistically, we find that miR-22 facilitates β-catenin stabilization through directly repressing citrullinase PAD2. Moreover, miR-22 also relieves DKK1-mediated repression of Wnt/β-catenin signaling by targeting a FosB-DDK1 transcriptional axis. miR-22 knockout mice showed attenuated Wnt/β-catenin activity and Lgr5+ CSCs penetrance, resulting in reduced occurrence, progression, and metastasis of chemically induced cutaneous squamous cell carcinoma (cSCC). Clinically, miR-22 is abundantly expressed in human cSCC. Its expression is even further elevated in the CSCs proportion, which negatively correlates with PAD2 and FosB expression. Inhibition of miR-22 markedly suppressed cSCC progression and increased chemotherapy sensitivity in vitro and in xenograft mice. Together, our results revealed a novel miR-22-WNT-CSCs regulatory mechanism in cSCC and highlight the important clinical application prospects of miR-22, a common target molecule for Wnt/β-catenin signaling and CSCs, for patient stratification and therapeutic intervention.

scholarly journals High expression of CD34 and α6-integrin contributes to the cancer-initiating cell behaviour in ultraviolet-induced mouse skin squamous cell carcinoma

2020 ◽  
Vol 11 (23) ◽  
pp. 6760-6767
Author(s):  
Hengning Ke ◽  
YvYing Yang ◽  
Yuan Lin ◽  
Li Liu ◽  
Jianmin Sun ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mouse Skin ◽  
High Expression ◽  
Cell Behaviour ◽  
Skin Squamous Cell Carcinoma
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