Exercise-induced changes in renal function and their relation to plasma noradrenaline in insulin-dependent diabetic children and adolescents

1987 ◽  
Vol 72 (5) ◽  
pp. 611-620 ◽  
Author(s):  
B.-L. Johansson ◽  
U. Berg ◽  
A.-B. Bohlin ◽  
A.-K. Lefvert ◽  
U. Freyschuss
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Plasma Noradrenaline ◽  
Diabetic Patients ◽  
Diabetic Children ◽  
Insulin Dependent ◽  
Exercise Induced ◽  
Insulin Dependent Diabetic ◽  
Induced Changes

1. Exercise-induced changes in renal haemodynamics, water homoeostasis, urinary albumin excretion and their possible relation to plasma noradrenaline were studied in seven insulin-dependent diabetic children and adolescents without signs of autonomic or somatic neuropathy. Six age-matched clinically healthy patients in remission from the minimal change nephrotic syndrome served as controls. 2. The diabetic patients had a higher glomerular filtration rate and effective renal plasma flow and a lower venous plasma noradrenaline level in the basal state. They also had a higher systolic blood pressure compared with the controls. During exercise the diabetic patients showed a less marked reduction in glomerular filtration rate and urinary flow and a greater increase in filtration fraction. Their heart rate increase during exercise was lower. An inverse correlation between the percentage changes in noradrenaline and glomerular filtration rate during exercise was noted solely in the diabetic patients. They also showed a less marked increase in the ratio between potassium and sodium clearances during and 20 min after exercise. Albumin excretion did not differ between the two groups. 3. We suggest that the sympatho-adrenergic effects of exercise on heart rate, renal haemodynamics and water homoeostasis are blunted in our diabetic patients. Hence, signs of impaired sympathetic activity might be disclosed in young diabetic patients with a disease of fairly short duration.

Feedback-mediated reduction in glomerular filtration during acetazolamide infusion in insulin-dependent diabetic patients

1991 ◽  
Vol 81 (s25) ◽  
pp. 457-464 ◽  
Author(s):  
T. Hannedouche ◽  
M. Lazaro ◽  
A. G. Delgado ◽  
C. Boitard ◽  
B. Lacour ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Angiotensin Ii ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Feedback System ◽  
Diabetic Patients ◽  
Control Subjects ◽  
Before And After ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

1. A sustained high glomerular filtration rate in diabetes mellitus is associated with increased proximal reabsorption, suggesting alterations in the tubulo-glomerular feedback system. To test this hypothesis, renal function was studied in eight control subjects and 14 recent-onset euglycaemic insulin-dependent diabetic patients before and after infusion of the carbonic anhydrase inhibitor, acetazolamide (5 mg/kg body weight). 2. Acetazolamide induced a dramatic fall in glomerular filtration rate in both diabetic patients and control subjects (from 138 ± 5 to 114 ± 4 and from 127 ± 3 to 113 ± 2 ml min−1 1.73 m−2, respectively, P < 0.0001). This fall in glomerular filtration rate was strongly correlated with the acetazolamide-induced decrease in absolute proximal reabsorption calculated by using lithium clearance. 3. To further assess the potential role of angiotensin II in the acetazolamide-induced tubulo-glomerular feedback response, 11 additional diabetic patients were investigated before and after the administration of acetazolamide plus the angiotensin-converting enzyme inhibitor, enalaprilat (1.25 mg intravenously). Despite the effective blockade of angiotensin II formation and a slight decrease in renal vascular resistance, the glomerular filtration rate fell significantly and by a similar magnitude as seen with acetazolamide alone. 4. These results indirectly suggest that there is an altered basal tubulo-glomerular feedback system in diabetic patients but a normal response to the increase in distal delivery. No convincing role for an angiotensin II-mediated effect on the afferent limb of the tubulo-glomerular feedback response could be demonstrated.

scholarly journals Impaired autoregulation of glomerular filtration rate in Type 1 (insulin-dependent) diabetic patients with nephropathy

Diabetologia ◽  
1984 ◽  
Vol 27 (6) ◽  
pp. 547-552 ◽  
Author(s):  
H. -H. Parving ◽  
H. Kastrup ◽  
U. M. Smidt ◽  
A. R. Andersen ◽  
B. Feldt-Rasmussen ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Diabetic Patients ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

scholarly journals РARTICULAR QUALITIES OF THE RENAL OSMOREGULATORY FUNCTION IN PATIENTS WITH TYPE 2 DIABETES

2015 ◽  
pp. 21-26 ◽  
Author(s):  
E.S. Kuznetsova ◽  
A.S. Kuznetsova ◽  
V.V. Shuhtin ◽  
A.I. Gozhenko
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Freezing Point ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
Osmoregulatory Function

The aim of the study was to examine the osmoregulatory state of renal function in patients with type 2 diabetes in a water - salt load with 0,5% NaCl in the amount of 0.5% of body weight. Materials and methods. The study involved 56patients with insulin - dependent diabetic nephropathy,24 men (42.9%) and 32 women (57.1%), aged from 38 to 81 years. The osmolality was measured by freezing point depression on osmomat 030 - D (USA). Glomerular filtration rate (GFR) was calculated by the formula GFR - EPI with subsequent determination of renal functional reserve. Results. It demonstrated that renal osmoregulatory function provides effective regulation of osmotic homeostasis even in a reduced amount of nephrons, but as the glomerular filtration rate decreses to 30 ml/min, the excretion of osmotically active substances gradually decrease too. Conclusion. Osmoregulatory disturbances in the renal function in patients with 2 types diabetes depend both on the reduction in GFR, - and on changes in the functional capacity of nephron's tubules.

scholarly journals Glucose-induced changes in renal haemodynamics in proteinuric Type 1 (insulin-dependent) diabetic patients: inhibition by acetylsalicilic acid infusion

Diabetologia ◽  
1993 ◽  
Vol 36 (7) ◽  
pp. 622-627 ◽  
Author(s):  
S. De Cosmo ◽  
K. Earle ◽  
A. Morocutti ◽  
J. Walker ◽  
P. Ruggenenti ◽  
...  
Keyword(s):  
Renal Haemodynamics ◽  
Diabetic Patients ◽  
Acid Infusion ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
Induced Changes

ARTIFICIAL NEURAL NETWORKS FOR ESTIMATING GLOMERULAR FILTRATION RATE BY URINARY DIPSTICK FOR TYPE 2 DIABETIC PATIENTS

2016 ◽  
Vol 28 (03) ◽  
pp. 1650016
Author(s):  
Yu Chu-Su ◽  
Chien-Sheng Liu ◽  
Ruey-Shin Chen ◽  
Chii-Wann Lin
Keyword(s):  
Diabetes Mellitus ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Diabetes Mellitus Type 2 ◽  
Filtration Rate ◽  
Optimal Combination ◽  
Diabetes Mellitus Type ◽  
Diabetic Patients ◽  
Test Items

Background: The result of a standard urinary dipstick from a patient with diabetes mellitus type 2 can be used to predict the estimated glomerular filtration rate (eGFR). We designed a multilayer perceptron (MLP) to investigate the possibility and optimal number of variables for the prediction. Methods: A total of 299 volunteers with diabetes mellitus type 2 were included. The blood and urine samples from volunteers were analyzed for blood sugar, glycated hemoglobin, serum creatinine, and urine chemistry. The urine chemistry was examined by a standard urinary dipstick. Volunteer age and gender and six test items of the dipstick were set as eight variables for this study. The eight variables were grouped and examined for the optimal combination. The eight variables from 232 of 299 volunteers were used to train an MLP for the optimal variables. The performance of trained MLP was validated by the data from 69 of 232 volunteers. Results: The optimal combination for variables was the six test items of the dipstick and volunteer age. The area under the curve (0.928), accuracy (0.879), sensitivity (0.83), and specificity (0.88) of the trained MLP were examined. Conclusions: The results demonstrate the eGFR prediction potential of the results of a urinary dipstick using this method.

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