Secretory immunoglobulin A and inhibitory activity of bacterial adherence to epithelial cells in urine from patients with urinary tract infections

1990 ◽  
Vol 18 (5) ◽  
pp. 305-308 ◽  
Author(s):  
A. Trinchieri ◽  
L. Braceschi ◽  
D. Tiranti ◽  
S. Dell'Acqua ◽  
A. Mandressi ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Epithelial Cells ◽  
Urinary Tract Infections ◽  
Inhibitory Activity ◽  
Immunoglobulin A ◽  
Bacterial Adherence ◽  
Secretory Immunoglobulin A ◽  
Tract Infections ◽  
Secretory Immunoglobulin

scholarly journals Fab-Independent Antiadhesion Effects of Secretory Immunoglobulin A on S-Fimbriated Escherichia coli Are Mediated by Sialyloligosaccharides

1998 ◽  
Vol 66 (8) ◽  
pp. 3971-3973 ◽  
Author(s):  
Horst Schroten ◽  
Christoph Stapper ◽  
Ricarda Plogmann ◽  
Henrik Köhler ◽  
Jörg Hacker ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Epithelial Cells ◽  
Human Milk ◽  
Immunoglobulin A ◽  
Secretory Immunoglobulin A ◽  
E Coli ◽  
Human Epithelial Cells ◽  
Early Human ◽  
Secretory Immunoglobulin

ABSTRACT S-fimbriated Escherichia coli strains cause sepsis and meningitis in newborns and are known to recognize the carbohydrate sequence sialyl-(α2-3)-galactoside. We show that adhesion of cloned S-fimbriated E. coli to human epithelial cells is inhibited Fab independently by sialyloligosaccharides on secretory immunoglobulin A (s-IgA). This indicates an anti-infective function of s-IgA (Fc), particularly in early human milk.

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