Elevated levels of secretory immunoglobulin A (sIgA) in urinary tract infections

2004 ◽  
Vol 71 (1) ◽  
pp. 37-40 ◽  
Author(s):  
Sudha S. Deo ◽  
Avinash K. Vaidya
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Immunoglobulin A ◽  
Secretory Immunoglobulin A ◽  
Tract Infections ◽  
Secretory Immunoglobulin

Secretory immunoglobulin A and inhibitory activity of bacterial adherence to epithelial cells in urine from patients with urinary tract infections

1990 ◽  
Vol 18 (5) ◽  
pp. 305-308 ◽  
Author(s):  
A. Trinchieri ◽  
L. Braceschi ◽  
D. Tiranti ◽  
S. Dell'Acqua ◽  
A. Mandressi ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Epithelial Cells ◽  
Urinary Tract Infections ◽  
Inhibitory Activity ◽  
Immunoglobulin A ◽  
Bacterial Adherence ◽  
Secretory Immunoglobulin A ◽  
Tract Infections ◽  
Secretory Immunoglobulin

The Role of Vaginal Immunoglobulin A in Girls with Recurrent Urinary Tract Infections

1978 ◽  
Vol 120 (6) ◽  
pp. 742-744 ◽  
Author(s):  
John P. Tuttle ◽  
Heikki Sarvas ◽  
Jukka Koistinen
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Immunoglobulin A ◽  
Recurrent Urinary Tract Infections ◽  
Tract Infections

Secretory immunoglobulin a in urinary tract infection, chronic glomerulonephritis, and renal transplantation

1989 ◽  
Vol 53 (2) ◽  
pp. 181-191 ◽  
Author(s):  
M. Marx ◽  
M. Weber ◽  
D. Schafranek ◽  
E. Wandel ◽  
K.-H. Meyer zum Büschenfelde ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Renal Transplantation ◽  
Urinary Tract ◽  
Tract Infection ◽  
Immunoglobulin A ◽  
Chronic Glomerulonephritis ◽  
Secretory Immunoglobulin A ◽  
Secretory Immunoglobulin

scholarly journals EsiB, a Novel Pathogenic Escherichia coli Secretory Immunoglobulin A-Binding Protein Impairing Neutrophil Activation

mBio ◽  
2013 ◽  
Vol 4 (4) ◽  
Author(s):  
Ilaria Pastorello ◽  
Silvia Rossi Paccani ◽  
Roberto Rosini ◽  
Rossella Mattera ◽  
Mario Ferrer Navarro ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Protective Antigen ◽  
Immunoglobulin A ◽  
Distribution Analysis ◽  
Secretory Immunoglobulin A ◽  
Content Type ◽  
E Coli ◽  
Novel Strategy ◽  
Tract Infections ◽  
Secretory Immunoglobulin

ABSTRACTIn this study, we have characterized the functional properties of a novelEscherichia coliantigen named EsiB (E. colisecretoryimmunoglobulin A-binding protein), recently reported to protect mice from sepsis. Gene distribution analysis of a panel of 267 strains representative of differentE. colipathotypes revealed thatesiBis preferentially associated with extraintestinal strains, while the gene is rarely found in either intestinal or nonpathogenic strains. These findings were supported by the presence of anti-EsiB antibodies in the sera of patients affected by urinary tract infections (UTIs). By solving its crystal structure, we observed that EsiB adopts a superhelical fold composed of Sel1-like repeats (SLRs), a feature often associated with bacterial proteins possessing immunomodulatory functions. Indeed, we found that EsiB interacts with secretory immunoglobulin A (SIgA) through a specific motif identified by an immunocapturing approach. Functional assays showed that EsiB binding to SIgA is likely to interfere with productive FcαRI signaling, by inhibiting both SIgA-induced neutrophil chemotaxis and respiratory burst. Indeed, EsiB hampers SIgA-mediated signaling events by reducing the phosphorylation status of key signal-transducer cytosolic proteins, including mitogen-activated kinases. We propose that the interference with such immune events could contribute to the capacity of the bacterium to avoid clearance by neutrophils, as well as reducing the recruitment of immune cells to the infection site.IMPORTANCEPathogenicEscherichia coliinfections have recently been exacerbated by increasing antibiotic resistance and the number of recurrent contagions. Attempts to develop preventive strategies againstE. colihave not been successful, mainly due to the large antigenic and genetic variability of virulence factors, but also due to the complexity of the mechanisms used by the pathogen to evade the immune system. In this work, we elucidated the function of a recently discovered protective antigen, named EsiB, and described its capacity to interact with secretory immunoglobulin A (SIgA) and impair effector functions. This work unravels a novel strategy used byE. colito subvert the host immune response and avoid neutrophil-dependent clearance.

A study of nurses' views about the prevention of nosocomial urinary tract infections

1997 ◽  
Vol 6 (5) ◽  
pp. 379-387 ◽  
Author(s):  
Jane C. Bridger
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Tract Infections

306: Relationships between Biofilm-Forming Capacities of Pseudomonas Aeruginosa Isolates and Clinical Background / Antimicrobial Resistence in Urinary Tract Infections

2007 ◽  
Vol 177 (4S) ◽  
pp. 102-103
Author(s):  
Shinya Uehara ◽  
Koichi Monden ◽  
Koichiro Wada ◽  
Ayano Ishii ◽  
Reiko Kariyama ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Clinical Background ◽  
Tract Infections

90: A Systematic Review of Urinary Tract Infections Following Transposition of Bowel Segments into Urinary Tract

2004 ◽  
Vol 171 (4S) ◽  
pp. 24-24 ◽  
Author(s):  
Nabi Ghulam ◽  
Sze M. Yong ◽  
Eng Ong ◽  
Adrian Grant ◽  
Gladys C. McPherson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Tract Infections ◽  
Bowel Segments
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