Inflammatory reactions after vascular prosthesis implantation: A comparison of gelatin-sealed and unsealed dacron prostheses

Surgery Today ◽  
1996 ◽  
Vol 26 (4) ◽  
pp. 258-261 ◽  
Author(s):  
Junichi Utoh ◽  
Yoshimasa Miyauchi ◽  
Hiraaki Goto ◽  
Hiroyuki Obayashi ◽  
Tomomi Hirata
Keyword(s):  
Vascular Prosthesis ◽  
Prosthesis Implantation ◽  
Inflammatory Reactions ◽  
Dacron Prostheses

Non-Thrombogenic Characteristics of Hybrid Vascular Prostheses

1979 ◽  
Author(s):  
P.N. Sawyer ◽  
B. Stanczewski
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Protein Structure ◽  
Thrombus Formation ◽  
Vascular Prosthesis ◽  
Short Term ◽  
Vascular Prostheses ◽  
Complete Occlusion ◽  
Dacron Prostheses ◽  
Scanning Electron

In our continuing efforts to develop a compound, coated vascular prosthesis, combining the best characteristics of biologic and nonbiologic materials, we have produced a hybri graft with pseudo biological coating. Five types of velour and knit dacron prostheses, have been cross linked subsequently with negatively charged proteins. Albumin and gelatin were used to coat the prosthesis or the combination of both. Following electrochemical characterization coated prostheses were implanted into the carotid and femoral arteries of dogs for 1 sec. 2 hr. and 1 mo. Preparations that showed promising short term results were implanted in the abdominal aorta of dogs for 18 months. Controls included uncoated prostheses and prostheses that had been coated but not negatively charged. Upon removal, the grafts were examined for thrombi and other luminal narrowings (photography, light and scanning electron microscopy). Fifty two uncoated and coated grafts have been examined. These exhibit a range of thrombus formation, from none to complete occlusion, in the various knit/coating combinations. We believe these hybrid prostheses will prove to be very useful in vascular reconstructive surgery due to (i) the nonthrombogenic characteristics of the negatively charged protein structure, (ii) more uniform healing and (iii) ease of implantation since preclotting is not necessary.

941: Peripheral and Corporal Blood Levels of Preoperative Vancomycin and Gentamycin in Patients Undergoing Penile Prosthesis Implantation

2007 ◽  
Vol 177 (4S) ◽  
pp. 311-312
Author(s):  
Heman Carrion ◽  
Jorge R. Caso ◽  
Gerard D. Henry ◽  
J. Christopher Webster ◽  
Rafael E. Carrion
Keyword(s):  
Penile Prosthesis ◽  
Blood Levels ◽  
Prosthesis Implantation

Degradable synthetic vascular prosthesis: experimental aortic replacement

2007 ◽  
Vol 55 (S 1) ◽  
Author(s):  
B Walpoth ◽  
M Cikirikcioglu ◽  
E Pektok ◽  
S Osorio-Da Cruz ◽  
JC Tille ◽  
...  
Keyword(s):  
Vascular Prosthesis ◽  
Aortic Replacement

Primary orbital prosthesis implantation as a method of cosmetic rehabilitation in children with retinoblastoma

2020 ◽  
pp. 175-176
Author(s):  
A.A. Yarovoy ◽  
◽  
T.L. Ushakova ◽  
N.V. Ivanova ◽  
O.V. Gorovtsova ◽  
...  
Keyword(s):  
Prosthesis Implantation ◽  
Orbital Prosthesis

Cytomorphometric characteristics of imprints of the contact area between the gingiva and the dental implant after one-step implantation

2017 ◽  
pp. 77-82
Author(s):  
А.С. Рыбалко ◽  
А.С. Григорьян ◽  
А.А. Орлов
Keyword(s):  
Dental Implants ◽  
Dental Implant ◽  
Contact Area ◽  
Inflammatory Reactions ◽  
Diagnosis And Prognosis ◽  
Dental Implantation ◽  
Data Points ◽  
One Step ◽  
Cytological Method ◽  
Clinical Pictures

Цель исследования состояла в разработке неинвазивного метода диагностики состояния тканей периимплантационной зоны после постановки дентальных имплантатов, а также прогноза течения послеоперационного периода и ранней диагностики послеоперационных осложнений, таких, как мукозит и периимплантит, при одноэтапном методе дентальной имплантации. Методы. В исследовании представлена цитологическая характеристика отпечатков из области контакта имплантата с десной, в которых оценивали состояние эпителиальных клеток при различных проявлениях цитопатологии. Определяли индекс деструкции (ИД) и воспалительно-деструктивный индекс (ВДИ) в клетках воспалительного инфильтрата, которые сопоставляли с клинической картиной течения послеоперационного периода. Сроки забора цитологического материала 1, 5, 15, 25, 30, 60, 120 дней после постановки имплантатов. Количество исследованных цитограмм - 442 от 11 пациентов (по 1-2 имплантата). Общий массив использованных для вычисления интегральных показателей составил »2550. Результаты. Было установлено, что в сроки 1-5 дней после постановки дентальных имплантатов происходит резкое повышение показателей ИД (до 7500 ± 15) и ВДИ (до 80 ± 20), что отражает процесс развития в области имплантатов острых воспалительных реакций. В отдаленные сроки наблюдений отмечалось 2 варианта развития событий. Первый из них характеризовался сохранением во все сроки высоких показателей ИД и ВДИ. Для второго варианта динамики показателей было характерно их падение, что соответствовало развитию процесса остеоинтеграции дентальных имплантатов. The objectives of the investigation were to develop protocols evaluating the validity and effectiveness of the cytological method for diagnosis and prognosis of tissue conditions adjacent to a dental implant. Methods. This study examined the cytological characteristics of imprints of the gingiva-implant contact area, a. the correlation of quantitative ratios of epithelial cells either with or without hystopathological manifestations (an index of destruction, ID); b. ratio of cells of the inflammatory infiltrate (an inflammatory and destructive index, IDI); these data were researched in relation with dynamics of the clinical pictures during a postoperative period.The cytological material was obtained 1, 5, 15, 25, 30, 60, 120 days after dental implantation. Totally 442 cytogramme from 11 patients (1-2 implant per a patient) were assayed. The data array for computation of integrated indicators was composed of ca. 2550 data points. Results. A significant increase of ID (7500 ± 15) and IDI (80 ± 20) indicators, which reflects the development of acute inflammatory reactions in tissues neighboring an implant, was observed within 1-5 days following the insertion of dental implants. Long-term observations revealed two scenarios. The first scenario was characterized by the retention of high levels of ID and IDI over the period of observations. The second scenario featured the reduction of ID and IDI indices, which corresponded to the development of the osseointegration of dental implants.

Recent Advances in Obesity: The Role of Turmeric Tuber and Its Metabolites in the Prophylaxis and Therapeutical Strategies

2019 ◽  
Vol 25 (37) ◽  
pp. 4837-4853 ◽  
Author(s):  
Agata Jarząb ◽  
Wirginia Kukula-Koch
Keyword(s):  
Body Weight ◽  
21St Century ◽  
The Body ◽  
Excess Body Weight ◽  
Inflammatory Reactions ◽  
Drug Candidates ◽  
Scientific Papers ◽  
Important Health ◽  
High Concern

Background: Obesity in the 21st century society became an important health problem, alarming both the scientists and medicine doctors around the world. That is why, the search for new drug candidates capable to reduce the body weight is of high concern. Objective: This contribution tends to collect current findings on the biochemistry of obesity and on the application of plants and in particular turmeric tuber – a commonly used spice - as an anti-obesity agent. Methods: Following an introduction on the biochemical characteristics of obesity, the description of Curcuma secondary metabolites, their pharmacological applications and a study on the plants’ regulatory properties in obesity was summarized. Particular attention was paid to curcumin – the major metabolite present in the extracts of Curcuma spp., which is known to exhibit a variety of pharmacological actions. Also, the characteristics of some semisynthetic analogues of this ferulic acid derivative, characterized by a higher polarity and better bioavailability will be discussed. Results: Numerous scientific papers treat on the influence of turmeric on weight loss. Additionally, some of them describe its anti-inflammatory properties. Conclusions: This important spice tends to fight the 21st century plague, which is an excessive weight gain, related to the development of metabolic syndrome, to the occurrence of cardiovascular problems and diabetes, and, in consequence, leading to a significant shortening of life span. As herein proven, the extracts of turmeric play an important role in the regulation of inflammatory reactions which are evoked in the overweight patients, helping them reduce the excess body weight.

The Role of Inflammasomes in Atherosclerosis and Stroke Pathogenesis

2020 ◽  
Vol 26 (34) ◽  
pp. 4234-4245
Author(s):  
Deepaneeta Sarmah ◽  
Aishika Datta ◽  
Swapnil Raut ◽  
Ankan Sarkar ◽  
Birva Shah ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
Treatment Strategies ◽  
Cerebrovascular Diseases ◽  
Cellular Injury ◽  
Inflammatory Reactions ◽  
Inflammatory Pathways

Inflammation is a devastating outcome of cerebrovascular diseases (CVD), namely stroke and atherosclerosis. Numerous studies over the decade have shown that inflammasomes play a role in mediating inflammatory reactions post cellular injury occurring after a stroke or a rupture of an atherosclerotic plaque. In view of this, targeting these inflammatory pathways using different pharmacological therapies may improve outcomes in patients with CVD. Here, we review the mechanisms by which inflammasomes drive the pathogenesis of stroke and atherosclerosis. Also, discussed here are the possible treatment strategies available for inhibiting inflammasomes or their up-stream/down-stream mediators.

scholarly journals Interactions of C-reactive protein with the complement system. III. Complement-dependent passive hemolysis initiated by CRP.

1975 ◽  
Vol 142 (5) ◽  
pp. 1065-1077 ◽  
Author(s):  
A.P. Osmand ◽  
R.F. Mortensen ◽  
Joan Siegel ◽  
H. Gewurz
Keyword(s):  
Guinea Pig ◽  
Human Serum ◽  
Complete System ◽  
Gel Filtration ◽  
C Reactive Protein ◽  
Inflammatory Reactions ◽  
Reactive Protein ◽  
Rabbit Igg ◽  
The Complement System ◽  
Pig Serum

Interactions of CRP with various substrates in the presence of human serum have been shown to result in efficient activation of C components C1-C5. We now report the ability of CRP to initiate C-dependent hemolysis. For this purpose CRP was isolated by affinity chromatography using pneumococcal CPS and gel filtration; its purity was established by several criteria. Erythrocytes were coated with CPS (E-CPS) and passively sensitized with CRP. C-dependent lysis of these cells was observed upon the addition of suitably absorbed human serum, and the efficiency of hemolysis compared favorably with that initiated by rabbit IgG anti-CPS antibody. CRP also sensitized E-CPS for lysis by guinea pig C; partial lysis was seen when C4-deficient guinea pig serum was used, suggesting that CRP also shares with antibody the ability of CRP to fully activate the C system and provide further evidence for a role for CRP similar to that of antibody in the initiation and modulation of inflammatory reactions via the complete system.

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