Role of the CDC8 gene in the repair of single strand breaks in DNA of the yeast Saccharomyces cerevisiae

1990 ◽  
Vol 18 (3) ◽  
pp. 175-179 ◽  
Author(s):  
H. Baranowska ◽  
D. Zaborowska ◽  
W. J. Jachymczyk ◽  
J. Żuk
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Single Strand ◽  
Yeast Saccharomyces Cerevisiae ◽  
Strand Breaks ◽  
Single Strand Breaks

scholarly journals The essential DNA polymerases delta and epsilon are involved in repair of UV-damaged DNA in the yeast Saccharomyces cerevisiae.

1999 ◽  
Vol 46 (2) ◽  
pp. 289-298 ◽  
Author(s):  
A Hałas ◽  
Z Policińska ◽  
H Baranowska ◽  
W J Jachymczyk
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Dna Repair ◽  
Uv Irradiation ◽  
Dna Polymerases ◽  
Relative Molecular Mass ◽  
Yeast Saccharomyces Cerevisiae ◽  
Strand Breaks ◽  
Single Strand Breaks ◽  
Mutant Strains ◽  
Cellular Dna

We have studied the ability of yeast DNA polymerases to carry out repair of lesions caused by UV irradiation in Saccharomyces cerevisiae. By the analysis of postirradiation relative molecular mass changes in cellular DNA of different DNA polymerases mutant strains, it was established that mutations in DNA polymerases delta and epsilon showed accumulation of single-strand breaks indicating defective repair. Mutations in other DNA polymerase genes exhibited no defects in DNA repair. Thus, the data obtained suggest that DNA polymerases delta and epsilon are both necessary for DNA replication and for repair of lesions caused by UV irradiation. The results are discussed in the light of current concepts concerning the specificity of DNA polymerases in DNA repair.

scholarly journals Hypermutability of Damaged Single-Strand DNA Formed at Double-Strand Breaks and Uncapped Telomeres in Yeast Saccharomyces cerevisiae

PLoS Genetics ◽  
2008 ◽  
Vol 4 (11) ◽  
pp. e1000264 ◽  
Author(s):  
Yong Yang ◽  
Joan Sterling ◽  
Francesca Storici ◽  
Michael A. Resnick ◽  
Dmitry A. Gordenin
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Double Strand Breaks ◽  
Single Strand ◽  
Yeast Saccharomyces Cerevisiae ◽  
Strand Breaks

scholarly journals Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks

2012 ◽  
Vol 41 (3) ◽  
pp. 1817-1828 ◽  
Author(s):  
Boris P. Belotserkovskii ◽  
Alexander J. Neil ◽  
Syed Shayon Saleh ◽  
Jane Hae Soo Shin ◽  
Sergei M. Mirkin ◽  
...  
Keyword(s):  
Dna Sequences ◽  
Single Strand ◽  
Strand Breaks ◽  
Sequence Composition ◽  
Single Strand Breaks ◽  
Transcription Blockage

scholarly journals The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA

BMC Genomics ◽  
2006 ◽  
Vol 7 (1) ◽  
Author(s):  
Rebecca C Fry ◽  
Michael S DeMott ◽  
Joseph P Cosgrove ◽  
Thomas J Begley ◽  
Leona D Samson ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Dna Damage ◽  
Single Strand ◽  
Strand Breaks ◽  
Single Strand Breaks

Role of Scavenger-Derived Radicals in the Induction of Double-Strand and Single-Strand Breaks in Irradiated DNA

1995 ◽  
Vol 142 (2) ◽  
pp. 133 ◽  
Author(s):  
Iraimoudi S. Ayene ◽  
Cameron J. Koch ◽  
Robert E. Krisch
Keyword(s):  
Single Strand ◽  
Strand Breaks ◽  
Single Strand Breaks
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