Occurrence of the neurosecretory substance during the embryonic development of the guinea pig

1970 ◽  
Vol 104 (4) ◽  
pp. 517-529 ◽  
Author(s):  
S. Donev
Keyword(s):  
Embryonic Development ◽  
Guinea Pig ◽  
Neurosecretory Substance

Insulin and insulinlike growth factors in embryonic development. Effects of a biologically inert insulin (guinea pig) on rat embryonic growth and development in vitro

Diabetes ◽  
1992 ◽  
Vol 41 (3) ◽  
pp. 318-324 ◽  
Author(s):  
J. P. Travers ◽  
L. Exell ◽  
B. Huang ◽  
E. Town ◽  
M. J. Lammiman ◽  
...  
Keyword(s):  
Growth Factors ◽  
Embryonic Development ◽  
Guinea Pig ◽  
Growth And Development ◽  
Embryonic Growth ◽  
Development In Vitro ◽  
Insulinlike Growth Factors

THE ANDROGENS IN THE GUINEA-PIG FOETUS THROUGHOUT THE EMBRYONIC DEVELOPMENT

1979 ◽  
Vol 92 (1) ◽  
pp. 174-186 ◽  
Author(s):  
N. Rigaudière
Keyword(s):  
Sexual Dimorphism ◽  
Embryonic Development ◽  
Guinea Pig ◽  
Sexual Differentiation ◽  
Sharp Increase ◽  
Foetal Life ◽  
Female Foetus ◽  
High Concentrations

ABSTRACT Testosterone (T) and dihydrotestosterone (DHT) content and concentration were measured by radioimmunoassay in plasma, gonads, adrenals, and sexual ducts of 235 male and 214 female guinea-pig foetuses at various stages of gestation after gonadal and adrenal differentiation occurred. In the male foetus, a sharp increase in the content and concentration of T and, to a lesser degree of DHT, is observed in the testis, the plasma and the ducts at the time of sexual differentiation between days 28 and 36. Thereafter androgen concentrations in these tissues decrease and rise again after day 52. In the female foetus, levels of T and DHT in the ovary are low throughout foetal life and do not account for the relatively high concentrations found in the plasma; in sexual ducts, T concentrations decrease at the time of differentiation. DHT levels are low at every stage. In both sexes, T and DHT are present in the adrenal. No sexual dimorphism is observed in the evolution of T and DHT adrenal content and concentration.

Fluorescent granules in the guinea-pig hypothalamus and their possible relation to neurosecretory substance

1970 ◽  
Vol 103 (4) ◽  
pp. 559-569 ◽  
Author(s):  
Merva K. W. Cottle ◽  
Ann Silver
Keyword(s):  
Guinea Pig ◽  
Neurosecretory Substance

Embryonic Development of the Specific Vestibular Hair Cell Pathology in A Strain of the Waltzing Guinea Pig

1983 ◽  
Vol 96 (5-6) ◽  
pp. 397-405 ◽  
Author(s):  
Aron Sobin ◽  
Matti Anniko
Keyword(s):  
Embryonic Development ◽  
Guinea Pig ◽  
Hair Cell

Insulin and Insulinlike Growth Factors in Embryonic Development: Effects of a Biologically Inert Insulin (Guinea Pig) on Rat Embryonic Growth and Development In Vitro

Diabetes ◽  
1992 ◽  
Vol 41 (3) ◽  
pp. 318-324 ◽  
Author(s):  
J. P. Travers ◽  
L. Exell ◽  
B. Huang ◽  
E. Town ◽  
M. J. Lammiman ◽  
...  
Keyword(s):  
Growth Factors ◽  
Embryonic Development ◽  
Guinea Pig ◽  
Growth And Development ◽  
Embryonic Growth ◽  
Development In Vitro ◽  
Insulinlike Growth Factors

Effect of Contraceptive Steroids on the Endometrium of Guinea Pig: SEM study

1977 ◽  
Vol 35 ◽  
pp. 668-669
Author(s):  
Mai M. Said ◽  
Ramesh K. Nayak ◽  
Randall E. McCoy
Keyword(s):  
Guinea Pig ◽  
Reproductive Tract ◽  
Three Dimensional ◽  
Female Reproductive Tract ◽  
Human Female ◽  
Surface Ultrastructure ◽  
Transmission Electron ◽  
Sem Study ◽  
Uterine Mucosa ◽  
Group 1

Burgos and Wislocki described changes in the mucosa of the guinea pig uterus, cervix and vagina during the estrous cycle investigated by transmission electron microscopy. More recently, Moghissi and Reame reported the effects of progestational agents on the human female reproductive tract. They found drooping and shortening of cilia in norgestrel and norethindrone- treated endometria. To the best of our knowledge, no studies concerning the effects of mestranol and norethindrone given concurrently on the three-dimensional surface features on the uterine mucosa of the guinea pig have been reported. The purpose of this study was to determine the effect of mestranol and norethindrone on surface ultrastructure of guinea pig uterus by SEM.Seventy eight animals were used in this study. They were allocated into two groups. Group 1 (20 animals) was injected intramuscularly 0.1 ml vegetable oil and served as controls.

Ultrastructure and Drug Metabolism in the Developing Guinea Pig

1973 ◽  
Vol 31 ◽  
pp. 538-539
Author(s):  
W. Kuenzig ◽  
M. Boublik ◽  
J.J. Kamm ◽  
J.J. Burns
Keyword(s):  
Guinea Pig ◽  
Metabolic Activity ◽  
Animal Species ◽  
Adult Animal ◽  
Smooth Endoplasmic Reticulum ◽  
Fetal Life ◽  
Mixed Function Oxidase ◽  
Cytochrome P 450 ◽  
Microsomal Mixed Function Oxidase ◽  
Mixed Function Oxidase Activity

Unlike a variety of other animal species, such as the rabbit, mouse or rat, the guinea pig has a relatively long gestation period and is a more fully developed animal at birth. Kuenzig et al. reported that drug metabolic activity which increases very slowly during fetal life, increases rapidly after birth. Hepatocytes of a 3-day old neonate metabolize drugs and reduce cytochrome P-450 at a rate comparable to that observed in the adult animal. Moreover the administration of drugs like phenobarbital to pregnant guinea pigs increases the microsomal mixed function oxidase activity already in the fetus.Drug metabolic activity is, generally, localized within the smooth endoplasmic reticulum (SER) of the hepatocyte.

Glycogen in guinea pig neutrophils: Ultrastructural study of neutrophils at the intradermal site of BCG injection

1983 ◽  
Vol 41 ◽  
pp. 726-727
Author(s):  
Corazon D. Bucana
Keyword(s):  
Bone Marrow ◽  
Guinea Pig ◽  
Electron Density ◽  
Peritoneal Cavity ◽  
Ultrastructural Study ◽  
Guinea Pigs ◽  
Random Distribution ◽  
Glycogen Content ◽  
Polymorphonuclear Neutrophils ◽  
Ultrastructural Studies

In the circulating blood of man and guinea pigs, glycogen occurs primarily in polymorphonuclear neutrophils and platelets. The amount of glycogen in neutrophils increases with time after the cells leave the bone marrow, and the distribution of glycogen in neutrophils changes from an apparently random distribution to large clumps when these cells move out of the circulation to the site of inflammation in the peritoneal cavity. The objective of this study was to further investigate changes in glycogen content and distribution in neutrophils. I chose an intradermal site because it allows study of neutrophils at various stages of extravasation.Initially, osmium ferrocyanide and osmium ferricyanide were used to fix glycogen in the neutrophils for ultrastructural studies. My findings confirmed previous reports that showed that glycogen is well preserved by both these fixatives and that osmium ferricyanide protects glycogen from solubilization by uranyl acetate.I found that osmium ferrocyanide similarly protected glycogen. My studies showed, however, that the electron density of mitochondria and other cytoplasmic organelles was lower in samples fixed with osmium ferrocyanide than in samples fixed with osmium ferricyanide.

Ultrastructural Studies on Genital Infection with the Chlamydial Agent of Guinea Pig Inclusion Conjunctivitis

1977 ◽  
Vol 35 ◽  
pp. 352-353
Author(s):  
B. L. Soloff ◽  
A. L. Barron ◽  
H. J. White ◽  
R. G. Rank
Keyword(s):  
Guinea Pig ◽  
Sexual Contact ◽  
Chlamydia Psittaci ◽  
Genital Infection ◽  
Major Site ◽  
Ultrastructural Studies ◽  
Tissue Specimens ◽  
Guinea Pig Model ◽  
Adequate Tissue ◽  
Genital Tissue

Chlamydial organisms (specifically C. trachomatis) have been implicated as a frequent cause of genital infection in the human (1). Study of the histo- pathological aspects of such infections has been impeded because of difficulties in obtaining adequate tissue specimens and the lack of a suitable experimental host. In 1964, Murray (2) isolated the causative agent of guinea pig inclusion conjunctivitis which possesses similarities to human inclusion conjunctivitis. This guinea pig organism was found to be a member of the Chlamydia psittaci subgroup and was designated as the Gp-ic agent. Male guinea pigs have been successfully infected with Gp-ic by intraurethral inoculation. Transmission of the infection to the female by sexual contact has been demonstrated (3). We are not aware of any ultrastructural studies to date concerning the development of this agent in genital tissue.Studies in our laboratory have established that, in our guinea pig model, the cervix is the major site of injection.

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