Prognostic significance of the patient's sex, tumor site, and mitotic rate in thin (?1.5 mm) melanoma

1984 ◽  
Vol 276 (3) ◽  
pp. 151-155 ◽  
Author(s):  
C. Kuehnl-Petzoldt ◽  
H. Keil ◽  
E. Schoepf
Keyword(s):  
Prognostic Significance ◽  
Mitotic Rate ◽  
Tumor Site

Reappraisal of the prognostic significance of mitotic rate supports its reincorporation into the melanoma staging system

Cancer ◽  
2020 ◽  
Vol 126 (21) ◽  
pp. 4717-4725
Author(s):  
Mohammed Kashani‐Sabet ◽  
James R. Miller ◽  
Serigne Lo ◽  
Mehdi Nosrati ◽  
Jonathan R. Stretch ◽  
...  
Keyword(s):  
Prognostic Significance ◽  
Staging System ◽  
Mitotic Rate

Advanced seminoma: treatment results, survival, and prognostic factors in 142 patients.

1994 ◽  
Vol 12 (1) ◽  
pp. 120-126 ◽  
Author(s):  
P J Mencel ◽  
R J Motzer ◽  
M Mazumdar ◽  
V Vlamis ◽  
D F Bajorin ◽  
...  
Keyword(s):  
Primary Tumor ◽  
Tumor Biology ◽  
Prognostic Significance ◽  
Complete Response ◽  
Serum Markers ◽  
Tumor Site ◽  
Primary Tumor Site ◽  
Treatment Regimens ◽  
Relative Risks ◽  
Platinum Based Chemotherapy

PURPOSE To investigate the efficacy of chemotherapy and to assess the relationship between selected pretreatment characteristics and survival in patients with advanced seminoma. PATIENTS AND METHODS One hundred forty-two patients with advanced seminoma treated with platinum-based chemotherapy were the subject of this study. Treatment regimens included cisplatin, vinblastine, bleomycin, cyclophosphamide, and dactinomycin (VAB-6) (45 patients), a six-cycle regimen of VAB-6 alternating with etoposide and cisplatin (two patients), cisplatin and etoposide (60 patients), and etoposide and carboplatin (35 patients). RESULTS One hundred thirty of 140 (93%) assessable patients treated with platinum-based therapy achieved a favorable response (complete response or a partial response with negative serum tumor markers). One hundred twenty-five patients (88%) are alive and 120 (86%) remain progression-free at a median follow-up duration of 43 months. Fifty-seven of 60 patients (95%) who were treated with cisplatin and etoposide achieved a favorable response; 55 (92%) remain progression-free. The relative risks of death or of an event (death or relapse) related to human chorionic gonadotropin (HCG) elevation were 1.8 (P = .04) and 1.96 (P = .001), respectively. The relative risks of death or of an event associated with lactate dehydrogenase (LDH) elevation were 2.6 (P = .05) and 2.7 (P = .02), respectively. All 19 patients with a mediastinal primary tumor site achieved a complete response, and 18 of 19 (95%) remain progression-free. CONCLUSION Four cycles of cisplatin and etoposide is highly effective therapy for seminoma and is the standard therapy at our center. Elevation of the serum markers HCG and LDH were of prognostic significance, while an extragonadal primary tumor site was not associated with an adverse prognosis. Studies of tumor biology, including genetic analysis, are ongoing to determine other parameters that may correlate with response and survival.

scholarly journals Prognostic Significance of Mitotic Rate in Localized Primary Cutaneous Melanoma: An Analysis of Patients in the Multi-Institutional American Joint Committee on Cancer Melanoma Staging Database

2011 ◽  
Vol 29 (16) ◽  
pp. 2199-2205 ◽  
Author(s):  
John F. Thompson ◽  
Seng-Jaw Soong ◽  
Charles M. Balch ◽  
Jeffrey E. Gershenwald ◽  
Shouluan Ding ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Prognostic Significance ◽  
Primary Melanoma ◽  
Mitotic Rate ◽  
Tumor Thickness ◽  
Survival Times ◽  
Anatomic Site ◽  
Primary Cutaneous Melanoma ◽  
American Joint Committee ◽  
Pathologic Features

Purpose The aim of this study was to assess the independent prognostic value of primary tumor mitotic rate compared with other clinical and pathologic features of stages I and II melanoma. Methods From the American Joint Committee on Cancer (AJCC) melanoma staging database, information was extracted for 13,296 patients with stages I and II disease who had mitotic rate data available. Results Survival times declined as mitotic rate increased. Ten-year survival ranged from 93% for patients whose tumors had 0 mitosis/mm2 to 48% for those with ≥ 20/mm2 (P < .001). Mean number of mitoses/mm2 increased as the primary melanomas became thicker (1.0 for melanomas ≤ 1 mm, 3.5 for 1.01 to 2.0 mm, 7.3 for 3.01 to 4.0 mm, and 9.6 for > 8 mm). Ulceration was also associated with a higher mitotic rate; 59% of ulcerated melanomas had ≥ 5 mitoses/mm2 compared with 16% of nonulcerated melanomas (P < .001). In a multivariate analysis of 10,233 patients, the independent predictive factors for survival in order of statistical significance were as follows: tumor thickness (χ2 = 104.9; P < .001), mitotic rate (χ2 = 67.0; P < .001), patient age (χ2 = 48.2; P < .001), ulceration (χ2 = 46.4; P < .001), anatomic site (χ2 = 34.6; P < .001), and patient sex (χ2 = 33.9; P < .001). Clark level of invasion was not an independent predictor of survival (χ2 = 3.2; P = .37). Conclusion A high mitotic rate in a primary melanoma is associated with a lower survival probability. Among the independent predictors of melanoma-specific survival, mitotic rate was the strongest prognostic factor after tumor thickness.

scholarly journals Rare Testicular Tumor Discovered by Assault: An Unusual Presentation of a Primary Testicular Neuroendocrine Tumor Grade 2

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Jonathan R. Epperson ◽  
Necia M. Pope ◽  
Margaret J. Abuzeid
Keyword(s):  
Neuroendocrine Tumor ◽  
Tunica Albuginea ◽  
Prognostic Significance ◽  
Testicular Tumor ◽  
Tumor Grade ◽  
Mitotic Rate ◽  
Unusual Presentation ◽  
Ki 67 ◽  
Nuclear Atypia ◽  
Mitotic Figures

Testicular neuroendocrine tumors (NET) or carcinoid tumors are rare neoplasms which represent 1% of all testicular tumors and can be divided into 3 subgroups: pure primary testicular NET, primary testicular NET associated with a teratoma, and NET metastases to the testis. We report an unusual presentation of a primary testicular neuroendocrine tumor in a 39-year-old male who presented after a physical altercation during a soccer game. Histology showed a diffuse infiltrating tumor with extensive involvement of the tunica albuginea and tunica vaginalis. Immunohistochemical expression of CD56, synaptophysin, and chromogranin A was strongly positive in the tumor cells. Foci of tumor cell necrosis and occasional mitotic figures as well as extensive lymph-vascular invasion were also identified. A review of the literature reveals differing opinions on the prognostic significance of primary tumor size, mitotic index, tumor necrosis, and nuclear atypia. In our patient, the increased mitotic rate (3–5 mitotic figures per 10 hpf and a Ki-67 index of 5%), foci of necrosis, and mild to moderate nuclear atypia warranted a diagnosis of neuroendocrine tumor grade 2, formerly atypical carcinoid. Long term surveillance in these patients is essential as metastasis occurs in up to 15% of cases. At the 6-month followup, the patient remains symptom free.

Value and prognostic significance of mitotic rate in a retrospective series of pT1 cutaneous malignant melanoma patients

2012 ◽  
Vol 36 (3) ◽  
pp. 303-305 ◽  
Author(s):  
G. Ponti ◽  
A. Pollio ◽  
A.M. Cesinaro ◽  
G. Pellacani ◽  
C. Magnoni ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Prognostic Significance ◽  
Mitotic Rate ◽  
Cutaneous Malignant Melanoma ◽  
Melanoma Patients

Prognostic significance for metastasis of Ki-67 and mitotic rate in cutaneous melanoma

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 7516-7516 ◽  
Author(s):  
P. A. Gimotty ◽  
P. Van Belle ◽  
D. E. Elder ◽  
K. Montone ◽  
T. Murry ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Prognostic Significance ◽  
Mitotic Rate ◽  
Ki 67

Prognostic impact of cancer-testis antigen expression in primary cutaneous melanoma

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 9004-9004
Author(s):  
J. S. Cebon ◽  
S. Svobodova ◽  
J. Browning ◽  
I. D. Davis ◽  
R. Scolyer ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Primary Melanoma ◽  
Mitotic Rate ◽  
Breslow Thickness ◽  
Small Range ◽  
Prognostic Impact ◽  
The Impact ◽  
Cancer Testis

9004 Background: Cancer-testis antigens (CTAg) are epigenetically regulated molecules expressed in many cancers including melanoma. Although functional studies are limited, they are often immunogenic making them attractive targets for immunotherapy. In normal tissues expression is restricted to germ cells and a small range of other tissues such as trophoblast. Previous studies have shown that CTAg expression increases with disease progression. We investigated whether the expression of three CTAgs, against which vaccines have been developed, may have prognostic significance in early stage melanoma. Methods: 233 AJCC Stage II melanomas were analyzed for expression of MAGE-A1, MAGE-A4 and NY-ESO-1 by immunohistochemistry. The relationship between CTAg expression, clinico-pathological features and relapse free survival (RFS) from initial diagnosis were correlated. Mutivariate analysis using known prognostic factors and CT Ag expression in the model were used to calculate hazard ratios. Results: All three CTAg were significantly co-expressed with each other (P=0.0001). RFS was reduced if tumors expressed any of these CTAgs (CTAg+ve). Median RFS for patients with CTAg+ve tumors was 45m versus 72m for those with CTAg-ve tumors (P=0.008, logrank test). Univariate analysis demonstrated that the impact of CTAg expression on RFS was comparable in magnitude to ulceration, Breslow thickness and mitotic rate, currently accepted prognostic factors. Multivariate analysis demonstrated CTAg expression, ulceration and thickness but not mitotic rate were independently associated with poorer RFS ( Table ). Conclusions: CTAg expression in cutaneous primary melanoma has impact on prognosis comparable to Breslow thickness ulceration and mitotic rate. Further study into their function and the impact of clinical targeting is warranted. [Table: see text] No significant financial relationships to disclose.

Prognostic significance of tumor mitotic rate in T2 melanoma staged with sentinel lymphadenectomy

2015 ◽  
Vol 111 (6) ◽  
pp. 711-715 ◽  
Author(s):  
Justin J. Baker ◽  
Michael O. Meyers ◽  
Allison M. Deal ◽  
Jill F. Frank ◽  
Karyn B. Stitzenberg ◽  
...  
Keyword(s):  
Prognostic Significance ◽  
Mitotic Rate ◽  
Sentinel Lymphadenectomy

scholarly journals Prognostic significance of regression and mitotic rate in head and neck cutaneous melanoma

2020 ◽  
Author(s):  
Elizabeth Kim ◽  
Isaac Obermeyer ◽  
Nathan Rubin ◽  
Samir S. Khariwala
Keyword(s):  
Head And Neck ◽  
Cutaneous Melanoma ◽  
Prognostic Significance ◽  
Mitotic Rate
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