Alteration in the sexual behaviour of male and female rats after neonatal administration of p-chlorophenylalanine

1972 ◽  
Vol 25 (2) ◽  
pp. 152-161 ◽  
Author(s):  
M. Hyypp� ◽  
Pirkko Lampinen ◽  
P�ivi Lehtinen
Keyword(s):  
Sexual Behaviour ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Neonatal Administration

Aspartic acid administered neonatally affects ventilation of male and female rats differently

1986 ◽  
Vol 61 (2) ◽  
pp. 780-784 ◽  
Author(s):  
E. H. Schlenker ◽  
M. Goldman
Keyword(s):  
Aspartic Acid ◽  
Ventilatory Response ◽  
Minute Ventilation ◽  
Female Rats ◽  
Male Rats ◽  
Metabolic Rates ◽  
Control Male ◽  
Male And Female ◽  
Male And Female Rats ◽  
Neonatal Administration

In this study ventilation was evaluated in 12-mo-old male and female rats who had received large doses of aspartic acid neonatally. Rats of both sexes treated with aspartic acid were obese, stunted, and exhibited hypogonadism. Although metabolic rates of the aspartic acid-treated rats were not different compared with sex-matched controls, ventilatory patterns were different. Aspartic acid-treated females breathed with a smaller tidal volume (VT), higher frequency (f), and similar minute ventilation (VE) compared with control females. This pattern is commonly observed in many patients who are obese. The aspartic acid-treated females responded to hypercapnic and hypoxic challenges by increasing f more than VT. Tissue pocket gases (PCO2 and PO2) of aspartic acid-treated females were normal. In contrast, aspartic acid-treated males hypoventilated compared with control males. Tissue pocket gas values suggested that aspartic acid-treated males were hypoxemic and hypercapnic. Moreover, the response of aspartic acid-treated males to hypercapnia was parallel to but was less than that of control male rats. The ventilatory response of aspartic acid-treated male rats to hypoxia was blunted. This study has shown that neonatal administration of aspartic acid causes a decreased ventilation and blunted response to hypoxia in adult male but not female rats.

FAILURE OF DIHYDROTESTOSTERONE TO ELICIT SEXUAL BEHAVIOUR IN THE FEMALE CAT

1977 ◽  
Vol 75 (1) ◽  
pp. 173-174 ◽  
Author(s):  
VERONICA A. CERNY
Keyword(s):  
Sexual Behaviour ◽  
Female Rats ◽  
University Of Pennsylvania ◽  
Male Rat ◽  
Peripheral Target ◽  
Target Tissue ◽  
Male And Female ◽  
Behavioural Effects ◽  
Male And Female Rats ◽  
Target Organs

Laboratory of Anatomy, Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, U.S.A. (Received 28 March 1977) Testosterones have stimulatory effects on peripheral target tissue and sexual behaviour in male and female rats (Beach, 1942), guinea-pigs (Young, 1961; Diamond & Young, 1963), rabbits (Palka & Sawyer, 1966; Beyer & Rivaud, 1973) and cats (Green, Clemente & de Groot, 1957; Young, 1961; Whalen & Hardy, 1970). 5α-Androstan-17β-ol-3-one (dihydrotestosterone, DHT) has stimulatory effects on peripheral target organs, and like testosterones, a negative feedback effect on the pituitary gland and hypothalamus (Feder, 1971). No behavioural effects were seen in male or female rats when DHT was injected systemically (Beyer, Morali & Cruz, 1971; Feder, 1971) nor in the male rat when it was administered intracerebrally (Johnston & Davidson, 1972). Many experiments support the hypothesis that only androgens that can be aromatized to oestrogens can elicit sexual behaviour and

Effects of neonatal administration of monosodium glutamate on plasma growth hormone (GH) response to GH-releasing factor in adult male and female rats

1986 ◽  
Vol 372 (2) ◽  
pp. 361-365 ◽  
Author(s):  
Ichiji Wakabayashi ◽  
Hisaaki Hatano ◽  
Shiro Minami ◽  
Yoji Tonegawa ◽  
Shigeo Akira ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Adult Male ◽  
Monosodium Glutamate ◽  
Female Rats ◽  
Plasma Growth Hormone ◽  
Male And Female ◽  
Male And Female Rats ◽  
Neonatal Administration

THE EFFECT OF NEONATAL ADMINISTRATION OF SEX HORMONES ON THE TURNOVER OF HEPATIC MICROSOMAL PHOSPHOLIPID IN MALE AND FEMALE RATS

1971 ◽  
Vol 49 (4) ◽  
pp. 659-665 ◽  
Author(s):  
Y. C. TOH
Keyword(s):  
Testosterone Propionate ◽  
Liver Microsomes ◽  
Total Content ◽  
P Uptake ◽  
Female Rats ◽  
Radioactive Phosphorus ◽  
Male And Female ◽  
Male And Female Rats ◽  
Neonatal Administration ◽  
Microsomal Phospholipid

SUMMARY The effect of neonatal administration of testosterone propionate and oestradiol benzoate on the metabolism of microsomal phospholipid in the liver of male and female rats was studied. Males had a greater uptake of radioactive phosphorus than females. Gonadectomy at the age of 4 weeks reduced the incorporation of 32P into the microsomal phospholipid. Administration of testosterone significantly increased 32P uptake both in the intact and ovariectomized females as well as in the castrated males, whereas oestradiol produced no effect. A sex difference of total microsomal phospholipid phosphorus was also found in the gonadectomized rats. Oestrogen caused no change in the intact animals but restored the level of phospholipid in ovariectomized female rats. On the other hand, testosterone significantly increased the total content of the phospholipid in the liver microsomes of both intact and gonadectomized male and female rats.

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