The effect of neonatal administration of testosterone and oestradiol on the liver nuclear volume of male and female rats

1971 ◽  
Vol 27 (5) ◽  
pp. 576-577 ◽  
Author(s):  
Yee-Chu Toh
Keyword(s):  
Nuclear Volume ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Neonatal Administration

Aspartic acid administered neonatally affects ventilation of male and female rats differently

1986 ◽  
Vol 61 (2) ◽  
pp. 780-784 ◽  
Author(s):  
E. H. Schlenker ◽  
M. Goldman
Keyword(s):  
Aspartic Acid ◽  
Ventilatory Response ◽  
Minute Ventilation ◽  
Female Rats ◽  
Male Rats ◽  
Metabolic Rates ◽  
Control Male ◽  
Male And Female ◽  
Male And Female Rats ◽  
Neonatal Administration

In this study ventilation was evaluated in 12-mo-old male and female rats who had received large doses of aspartic acid neonatally. Rats of both sexes treated with aspartic acid were obese, stunted, and exhibited hypogonadism. Although metabolic rates of the aspartic acid-treated rats were not different compared with sex-matched controls, ventilatory patterns were different. Aspartic acid-treated females breathed with a smaller tidal volume (VT), higher frequency (f), and similar minute ventilation (VE) compared with control females. This pattern is commonly observed in many patients who are obese. The aspartic acid-treated females responded to hypercapnic and hypoxic challenges by increasing f more than VT. Tissue pocket gases (PCO2 and PO2) of aspartic acid-treated females were normal. In contrast, aspartic acid-treated males hypoventilated compared with control males. Tissue pocket gas values suggested that aspartic acid-treated males were hypoxemic and hypercapnic. Moreover, the response of aspartic acid-treated males to hypercapnia was parallel to but was less than that of control male rats. The ventilatory response of aspartic acid-treated male rats to hypoxia was blunted. This study has shown that neonatal administration of aspartic acid causes a decreased ventilation and blunted response to hypoxia in adult male but not female rats.

Effects of neonatal administration of monosodium glutamate on plasma growth hormone (GH) response to GH-releasing factor in adult male and female rats

1986 ◽  
Vol 372 (2) ◽  
pp. 361-365 ◽  
Author(s):  
Ichiji Wakabayashi ◽  
Hisaaki Hatano ◽  
Shiro Minami ◽  
Yoji Tonegawa ◽  
Shigeo Akira ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Adult Male ◽  
Monosodium Glutamate ◽  
Female Rats ◽  
Plasma Growth Hormone ◽  
Male And Female ◽  
Male And Female Rats ◽  
Neonatal Administration

THE EFFECT OF NEONATAL ADMINISTRATION OF SEX HORMONES ON THE TURNOVER OF HEPATIC MICROSOMAL PHOSPHOLIPID IN MALE AND FEMALE RATS

1971 ◽  
Vol 49 (4) ◽  
pp. 659-665 ◽  
Author(s):  
Y. C. TOH
Keyword(s):  
Testosterone Propionate ◽  
Liver Microsomes ◽  
Total Content ◽  
P Uptake ◽  
Female Rats ◽  
Radioactive Phosphorus ◽  
Male And Female ◽  
Male And Female Rats ◽  
Neonatal Administration ◽  
Microsomal Phospholipid

SUMMARY The effect of neonatal administration of testosterone propionate and oestradiol benzoate on the metabolism of microsomal phospholipid in the liver of male and female rats was studied. Males had a greater uptake of radioactive phosphorus than females. Gonadectomy at the age of 4 weeks reduced the incorporation of 32P into the microsomal phospholipid. Administration of testosterone significantly increased 32P uptake both in the intact and ovariectomized females as well as in the castrated males, whereas oestradiol produced no effect. A sex difference of total microsomal phospholipid phosphorus was also found in the gonadectomized rats. Oestrogen caused no change in the intact animals but restored the level of phospholipid in ovariectomized female rats. On the other hand, testosterone significantly increased the total content of the phospholipid in the liver microsomes of both intact and gonadectomized male and female rats.

THE PITUITARY AND ADRENAL RESPONSES TO ADMINISTRATION OF OESTRIOL IN GONADECTOMIZED RATS

1961 ◽  
Vol 38 (1) ◽  
pp. 50-58 ◽  
Author(s):  
N. E. Borglin ◽  
L. Bjersing
Keyword(s):  
Pituitary Gland ◽  
Adrenal Cortex ◽  
Clinical Experience ◽  
Uterine Cervix ◽  
Morphological Changes ◽  
Physiological Significance ◽  
Female Rats ◽  
Experimental Conditions ◽  
Male And Female ◽  
Male And Female Rats

ABSTRACT Oestriol (oestra-1,3,5(10)-triene-3,16α,17β-triol) is a weakly oestrogenic substance which, however, in contrast to what was formerly believed, is of physiological significance. Its effect is localized largely to the uterine cervix and vagina. Clinical experience argues both for and against an effect on the pituitary gland. This investigation is concerned with the morphological changes in the pituitary gland and adrenal cortex of gonadectomized male and female rats after the injection of oestriol. It was found that oestriol has the same type of action on these glands as other oestrogens, but under the experimental conditions used, this effect proved much weaker than that produced by oestradiol (oestra-1,3,5(10)-triene-3,17β-diol).

INDUCTION OF GOITRE BY PTU OR KClO4 IN MALE AND FEMALE RATS. EFFECT OF GONADECTOMY

1973 ◽  
Vol 74 (1) ◽  
pp. 88-104 ◽  
Author(s):  
T. Jolín ◽  
M. J. Tarin ◽  
M. D. Garcia
Keyword(s):  
Iodine Content ◽  
High Plasma ◽  
Disc Electrophoresis ◽  
Female Rats ◽  
Male Rats ◽  
Adult Rats ◽  
Male And Female ◽  
Glucose Levels ◽  
Male And Female Rats ◽  
Tsh Levels

ABSTRACT Male and female rats of varying ages were placad on a low iodine diet (LID) plus KClO4 or 6-propyl-2-thiouracil (PTU) or on the same diet supplemented with I (control rats). Goitrogenesis was also induced with LID plus PTU in gonadectomized animals of both sexes. The weight of the control and goitrogen treated animals, and the weight and iodine content of their thyroids were determined, as well as the plasma PBI, TSH, insulin and glucose levels. The pituitary GH-like protein content was assessed by disc electrophoresis on polyacrylamide gels. If goitrogenesis was induced in young rats of both sexes starting with rats of the same age, body weight (B.W.) and pituitary growth hormone (GH) content, it was found that both the males and females developed goitres of the same size. On the contrary, when goitrogenesis was induced in adult animals, it was found that male rats, that had larger B.W. and pituitary GH content than age-paired females, developed larger goitres. However, both male and female rats were in a hypothyroid condition of comparable degree as judged by the thyroidal iodine content and the plasma PBI and TSH levels. When all the data on the PTU or KClO4-treated male and female rats of varying age and B.W. were considered together, it was observed that the weights of the thyroids increased proportionally to B.W. However, a difference in the slope of the regression of the thyroid weight over B.W. was found between male and female rats, due to the fact that adult male rats develop larger goitres than female animals. In addition, in the male rats treated with PTU, gonadectomy decreased the B.W., pituitary content of GH-like protein and, concomitantly, the size of the goitre decreased; an opposite effect was induced by ovariectomy on the female animals. However, when goitrogenesis was induced in weight-paired adult rats of both sexes, the male animals still developed larger goitres than the females. Among all the parameters studied here, the only ones which appeared to bear a consistent relationship with the size of the goitres in rats of different sexes, treated with a given goitrogen, were the rate of body growth and the amount of a pituitary GH-like protein found before the onset of the goitrogen treatment. Moreover, though the pituitary content of the GH-like protein decreased as a consequence of goitrogen treatment, it was still somewhat higher in male that in female animals. The present results suggest that GH may somehow be involved in the mechanism by which male and female rats on goitrogens develop goitres of different sizes, despite equally high plasma TSH levels.

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