Pyridine nucleotide metabolism in imaginal discs of Drosophila melanogaster

1976 ◽  
Vol 14 (3-4) ◽  
pp. 197-207 ◽  
Author(s):  
Ted W. Keyes ◽  
Baldomero M. Olivera ◽  
D. J. Stewart ◽  
E. W. Hanly
Keyword(s):  
Drosophila Melanogaster ◽  
Pyridine Nucleotide ◽  
Imaginal Discs ◽  
Nucleotide Metabolism

scholarly journals Pyridine Nucleotide Metabolism: Mechanism of Action of the Niacin Antagonist, 6-Aminonicotinamide

1958 ◽  
Vol 233 (4) ◽  
pp. 964-968
Author(s):  
L.S. Dietrich ◽  
Ira M. Friedland ◽  
Leatrice A. Kaplan
Keyword(s):  
Mechanism Of Action ◽  
Pyridine Nucleotide ◽  
Nucleotide Metabolism

scholarly journals Imaginal discs regulate developmental timing in Drosophila melanogaster

2008 ◽  
Vol 321 (1) ◽  
pp. 18-26 ◽  
Author(s):  
Bradley C. Stieper ◽  
Mania Kupershtok ◽  
Michael V. Driscoll ◽  
Alexander W. Shingleton
Keyword(s):  
Drosophila Melanogaster ◽  
Imaginal Discs ◽  
Developmental Timing

Comparative Analysis of Spatial Patterns of Gene Expression in Drosophila melanogaster Imaginal Discs

2007 ◽  
pp. 533-547 ◽  
Author(s):  
Cyrus L. Harmon ◽  
Parvez Ahammad ◽  
Ann Hammonds ◽  
Richard Weiszmann ◽  
Susan E. Celniker ◽  
...  
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Comparative Analysis ◽  
Spatial Patterns ◽  
Imaginal Discs

scholarly journals Resveratrol Stimulates Cortisol Biosynthesis by Activating SIRT-Dependent Deacetylation of P450scc

Endocrinology ◽  
2012 ◽  
Vol 153 (7) ◽  
pp. 3258-3268 ◽  
Author(s):  
Donghui Li ◽  
Eric B. Dammer ◽  
Marion B. Sewer
Keyword(s):  
Protein Expression ◽  
Fold Increase ◽  
Pyridine Nucleotide ◽  
Nucleotide Metabolism ◽  
Side Chain ◽  
Mitochondrial Enzyme ◽  
Adrenocortical Cells ◽  
Protein Levels ◽  
Chain Cleavage ◽  
Cleavage Enzyme

In the human adrenal cortex, cortisol is synthesized from cholesterol by members of the cytochrome P450 superfamily and hydroxysteroid dehydrogenases. Both the first and last steps of cortisol biosynthesis occur in mitochondria. Based on our previous findings that activation of ACTH signaling changes the ratio of nicotinamide adenine dinucleotide (NAD) phosphate to reduced NAD phosphate in adrenocortical cells, we hypothesized that pyridine nucleotide metabolism may regulate the activity of the mitochondrial NAD+-dependent sirtuin (SIRT) deacetylases. We show that resveratrol increases the protein expression and half-life of P450 side chain cleavage enzyme (P450scc). The effects of resveratrol on P450scc protein levels and acetylation status are dependent on SIRT3 and SIRT5 expression. Stable overexpression of SIRT3 abrogates the cellular content of acetylated P450scc, concomitant with an increase in P450scc protein expression and cortisol secretion. Mutation of K148 and K149 to alanine stabilizes the expression of P450scc and results in a 1.5-fold increase in pregnenolone biosynthesis. Finally, resveratrol also increases the protein expression of P450 11β, another mitochondrial enzyme required for cortisol biosynthesis. Collectively, this study identifies a role for NAD+-dependent SIRT deacetylase activity in regulating the expression of mitochondrial steroidogenic P450.

scholarly journals Regulation of Pyridine Nucleotide Metabolism During Tomato Fruit Development Through Transcript and Protein Profiling

2019 ◽  
Vol 10 ◽  
Author(s):  
Guillaume Decros ◽  
Bertrand Beauvoit ◽  
Sophie Colombié ◽  
Cécile Cabasson ◽  
Stéphane Bernillon ◽  
...  
Keyword(s):  
Fruit Development ◽  
Tomato Fruit ◽  
Pyridine Nucleotide ◽  
Nucleotide Metabolism ◽  
Protein Profiling
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