Studies on the mechanism of the action of morphine on the peristalsis of guinea pig ileum in situ

1975 ◽  
Vol 291 (4) ◽  
pp. 395-403 ◽  
Author(s):  
Jorge Aldunate ◽  
Luna Yojay ◽  
Jorge Mardones
Keyword(s):  
Guinea Pig ◽  
Guinea Pig Ileum

The Conversion of Methyl-2-Acetoxyethyl-2′-Chloroethylamine to an Acetylcholine-Like Aziridinium Ion and its Action on the Isolated Guinea Pig Ileum

1972 ◽  
Vol 50 (8) ◽  
pp. 798-808 ◽  
Author(s):  
M. Hirst ◽  
C. H. Jackson
Keyword(s):  
Aqueous Solution ◽  
Guinea Pig ◽  
Muscle Tone ◽  
Recovery Period ◽  
Induced Responses ◽  
Agonist Activity ◽  
Guinea Pig Ileum ◽  
Aziridinium Ion ◽  
Treatment Responses

Methyl-2-acetoxyethyl-2′-chloroethylamine (acetyicholine-mustard) isomerizes in aqueous solution to form a cyclic ion, N-methyl-N-(2-acetoxyethyl)aziridinium, which structurally resembles acetylcholine. It is a potent stimulant of the guinea pig ileum, being approximately one-sixth as potent as acetylcholine at pH 7.4 and one-third as potent at pH 8.4. The agonist activity is inhibited by atropine, by preincubation with acetylcholinesterase, and pretreatment with thiosulfate ion. Mepyramine does not inhibit the stimulant action.One hour exposures of ileum segments to concentrations of acetylcholine-mustard in excess of those producing maximal responses, followed by a 1 h recovery period, did not produce evidence of postsynaptic receptor alkylation. Post-treatment responses to acetylcholine were slightly depressed, but these reductions were not related to the incubation concentrations of the agonist haloalkylamine. Pilocarpine-induced responses were unaltered by this treatment whereas 5-hydroxytryptamine responses were slightly potentiated and histamine responses were slightly and inconsistently modified.These treatments produced persistent, dose-related increases in muscle tone, an effect consistent with accumulations of spontaneously liberated acetylcholine and possibly caused by inhibition of in situ acetylcholinesterase.Ostensibly, the evidence suggests that the acetylcholine-like aziridinium ion can stimulate, but not inhibit, the muscarinic receptors of the guinea pig ileum.

Acute morphological changes in guinea-pig ileum myenteric neurons after ischemia in situ with superfusion in vitro

2008 ◽  
Vol 204 (2) ◽  
pp. 121-127 ◽  
Author(s):  
Rosa Ventura-Martinez ◽  
Jacinto Santiago-Mejia ◽  
Claudia Gomez ◽  
Rodolfo Rodriguez ◽  
Teresa I. Fortoul
Keyword(s):  
Guinea Pig ◽  
Morphological Changes ◽  
Guinea Pig Ileum ◽  
Myenteric Neurons

Indomethacin (INDO) changes peristaltic reflex of guinea pig ileum in multiple, short, shallow and ineffectual contractions

2001 ◽  
Vol 120 (5) ◽  
pp. A226-A226
Author(s):  
K SCHULZE ◽  
J FENTON
Keyword(s):  
Guinea Pig ◽  
Guinea Pig Ileum ◽  
Peristaltic Reflex

Sites and mechanisms of dependence in the myenteric plexus of guinea pig ileum.

1984 ◽  
Author(s):  
Harry O. Collier ◽  
John F. Tucker
Keyword(s):  
Guinea Pig ◽  
Myenteric Plexus ◽  
Guinea Pig Ileum

Anti-inflammatory effect of Mitragyna speciosa crude methanol extract on the guinea pig ileum

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
WM Shaik Mossadeq ◽  
K Syamimi ◽  
MP Azyyati ◽  
ZA Zakaria ◽  
AK Arifah ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Methanol Extract ◽  
Guinea Pig Ileum ◽  
Mitragyna Speciosa ◽  
Anti Inflammatory ◽  
Crude Methanol Extract ◽  
Inflammatory Effect

Preparation and properties of three analogues of [5-leucine]enkephalin, substrates for enzyme conversion studies

1985 ◽  
Vol 50 (6) ◽  
pp. 1329-1334
Author(s):  
Jaroslav Vičar ◽  
Linda Servítová ◽  
Martin Flegel ◽  
Karel Hauzer ◽  
Tomislav Barth
Keyword(s):  
High Pressure ◽  
Liquid Chromatography ◽  
Guinea Pig ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Guinea Pig Ileum ◽  
Opioid Activity ◽  
C Terminus ◽  
N Terminus ◽  
Fragment Condensation

Analogues of [5-Leu]enkephalin, prolonged by methionine on the N-terminus or, by lysine or methionine on the C-terminus were prepared by fragment condensation, purified by ion exchange chromatography or high-pressure liquid chromatography. The substances were characterised by their opioid activity in a test on guinea-pig ileum in comparison with the activity of [5-Leu]enkephalin.

scholarly journals A STUDY OF THE METABOLIC REQUIREMENTS FOR THE CONTRACTILE ACTION OF ANGIOTENSIN UPON GUINEA-PIG ILEUM

1974 ◽  
Vol 51 (1) ◽  
pp. 73-79 ◽  
Author(s):  
ANN D. CROCKER ◽  
K.A. WILSON
Keyword(s):  
Guinea Pig ◽  
Guinea Pig Ileum

Two types of P2x-purinoceptors in neurons of the guinea pig ileum submucous plexus

1998 ◽  
Vol 30 (4-5) ◽  
pp. 242-245 ◽  
Author(s):  
A. V. Glushakov ◽  
H. Yu. Glushakova ◽  
V. I. Skok
Keyword(s):  
Guinea Pig ◽  
Guinea Pig Ileum ◽  
Submucous Plexus
Sign in / Sign up

Export Citation Format

Share Document