Thin-layer chromatography on cellulose. Monoquaternary ammonium salts

1981 ◽  
Vol 15 (9) ◽  
pp. 687-688
Author(s):  
N. S. Volkova ◽  
T. B. Primakova ◽  
S. D. Sokolov
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Ammonium Salts ◽  
Layer Chromatography ◽  
Monoquaternary Ammonium

Thin-layer chromatography of certain quaternary ammonium salts of derivatives of p-aminosalicylic acid

1972 ◽  
Vol 6 (9) ◽  
pp. 618-620
Author(s):  
A. M. Khaletskii ◽  
L. F. Travushkina ◽  
L. R. Nagornaya
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Aminosalicylic Acid ◽  
Layer Chromatography ◽  
Derivatives Of

Thin-layer chromatography of quaternary ammonium salts on alumina layers

1972 ◽  
Vol 74 (2) ◽  
pp. 297-302 ◽  
Author(s):  
W.F.H. McLean ◽  
K. Jewers
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Layer Chromatography

scholarly journals Synthesis of quaternary ammonium salts based on quinuclidin-3-ol and pyridine-4-aldoxime with alkyl chains

St open ◽  
2020 ◽  
Vol 1 ◽  
pp. 1-8
Author(s):  
Doris Crnčević ◽  
Renata Odžak
Keyword(s):  
Melting Point ◽  
Nitrogen Atom ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Antimicrobial Agents ◽  
Ftir Spectra ◽  
Ammonium Salts ◽  
Product Yields ◽  
Alkyl Chains ◽  
Layer Chromatography

Aim: In search of a new class of potential antimicrobial agents, novel ammonium salts based on quinuclidine-3-ol and pyridine-4-aldoxime with different lengths of alkyl chains were synthesized and analyzed. In addition to their potential biological application, newly synthesized salts containing terminal bromine could possibly be used for the synthesis of more potent bisquaternary salts. Methods: The commercially available quinuclidine-3-ol and pyridine-4-aldoxime were used for the synthesis of new derivatives with the appropriate alkyl chains. The purity of the synthesized salts was tested by thin-layer chromatography on an aluminum plate where aluminum oxide was used as a stationary phase. Melting points were determined in open capillaries using an instrument for melting point determination and the obtained values were left uncorrected. The FTIR spectra were recorded with a spectrometer and the data were analyzed in cm-1. Results: All the synthesized compounds, which contained heterocyclic moiety and alkyl chains (with or without a terminal bromine atom), were obtained in very good yields under the simple quaternization conditions. The better product yields were observed in reactions with quinuclidine3-ol (46-95%) compared to those with pyridine-4-aldoxime (49-59%). The obtained products were analyzed and confirmed by the thin-layer chromatography, the melting point measurement and the FTIR spectra. Conclusion: The observed difference in product yields could be explained by the different basicity of the nitrogen atom of quinuclidin-3-ol than that of pyridine-4-aldoxime. All prepared salts have a positively charged nitrogen atom as a part of their polar “head” and a long hydrocarbon chain as the non-polar “tail”. Such a structure allows electrostatic interaction with the negatively charged bacterial membrane and causes it to be disrupted. The structure of the prepared salts containing long alkyl chains could be crucial for their antimicrobial activity.

Identification of chemotypesin Holy Basil (Ocimum sanctum) by High Performance Thin Layer Chromatography (HPTLC)

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
T Schinle ◽  
I Merfort ◽  
D Frommenwiler ◽  
E Reich
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
High Performance ◽  
Ocimum Sanctum ◽  
Layer Chromatography ◽  
Holy Basil

Thin-Layer Chromatography

1965 ◽  
Author(s):  
H. R. Bolliger ◽  
M. Brenner ◽  
H. Gänshirt ◽  
Helmut K. Mangold ◽  
H. Seiler ◽  
...  
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Layer Chromatography

THE LESS-POLAR METABOLITES PRODUCED BY INCUBATION OF TESTOSTERONE-4-14C WITH RAT AND BOVINE BRAIN

1969 ◽  
Vol 61 (4) ◽  
pp. 641-648 ◽  
Author(s):  
Leon J. Sholiton ◽  
Emile E. Werk
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Paper Chromatography ◽  
Specific Activity ◽  
Bovine Brain ◽  
Polar Fraction ◽  
End Products ◽  
Polar Metabolites ◽  
Layer Chromatography ◽  
Constant Specific Activity

ABSTRACT Rat and bovine brain have been incubated with testosterone-4-14C under standard conditions. With use of paper chromatography, the extracted metabolites were noted to fall into less-polar, iso-polar, and more polar fractions. The components of the less-polar fraction were separated by acetylation and thin-layer chromatography and the major end-products identified by recrystallization to constant specific activity or constant 3H/14C ratios. Androst-4-enedione and 5α-dihydrotestosterone were formed consistently under the conditions utilized. Trace amounts of other less-polar metabolites were noted occasionally.

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