Effects of N substituents on structure in 2-N-substituted 8-oxyquinolines: Conjugation between the unshared electron pair on the nitrogen atom and the aromatic ring

1989 ◽  
Vol 30 (2) ◽  
pp. 301-324 ◽  
Author(s):  
Z. A. Starikova
Keyword(s):  
Nitrogen Atom ◽  
Aromatic Ring ◽  
Electron Pair ◽  
Unshared Electron Pair

Orientation of the unshared electron pair of the nitrogen atom in N-substituted 2,5-dimethyl-4-piperidinones

1989 ◽  
Vol 25 (4) ◽  
pp. 426-427
Author(s):  
A. �. Aliev ◽  
A. A. Fomichev
Keyword(s):  
Nitrogen Atom ◽  
Electron Pair ◽  
Unshared Electron Pair

Dirhodium-Catalyzed Chemo- and Site-Selective C–H Amidation of N,N-Dialkylanilines

Synlett ◽  
2020 ◽  
Author(s):  
Yoshihiro Ueda ◽  
Gong Chen ◽  
Kenta Arai ◽  
Kazuhiro Morisaki ◽  
Takeo Kawabata
Keyword(s):  
Nitrogen Atom ◽  
Aromatic Ring ◽  
Methyl Group ◽  
Site Selective

AbstractA method for dirhodium-catalyzed C(sp3)–H amidation of N,N-dimethylanilines was developed. Chemoselective C(sp3)–H amidation of N-methyl group proceeded exclusively in the presence of C(sp2)–H bonds of the electron-rich aromatic ring. Site-selective C(sp3)–H amidation proceeded exclusively at the N-methyl group of N-methyl-N-alkylaniline derivatives with secondary, tertiary, and benzylic C(sp3)–H bonds α to a nitrogen atom.

Structure and bonding in cyclic phosphoramidates as determined by carbon-13 magnetic resonance

1979 ◽  
Vol 57 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Gerald W. Buchanan ◽  
Frederick G. Morin
Keyword(s):  
Magnetic Resonance ◽  
Nitrogen Atom ◽  
Electron Pair ◽  
Chemical Shifts ◽  
Lone Pair ◽  
Ring Conformation ◽  
Delocalized Electron ◽  
Nitrogen Lone Pair ◽  
Structure And Bonding

13C chemical shifts and 13C–31P couplings are reported for 11 cyclic phosphoramidates of ring sizes from four to nine. Vicinal couplings are compared with those of carbocyclic analogs and provide insight regarding the degree of nitrogen lone pair derealization into the N—P bond. For six-membered and larger rings, there appears to be nearly complete lone pair delocalization, i.e., a trigonal planar nitrogen atom. In azetidine derivatives the nitrogen lone pair remains localized, giving rise to a highly puckered ring conformation. Pyrrolidine derivatives are viewed as having a nitrogen with a partially delocalized electron pair.

Infrared spectra of the interactions of aniline and porous glass surfaces

1969 ◽  
Vol 47 (8) ◽  
pp. 1281-1287 ◽  
Author(s):  
M. J. D. Low ◽  
V. V. Subba Rao
Keyword(s):  
Nitrogen Atom ◽  
Aromatic Ring ◽  
Secondary Amine ◽  
Infrared Spectra ◽  
Porous Glass ◽  
Weak Interactions ◽  
Amine Group ◽  
Oh Groups ◽  
Glass Surfaces ◽  
Adsorption And Dissociation

Infrared spectra were recorded of aniline sorbed on highly dehydroxylated, deuterated, and on fluoridated porous glass as well as on pure and boria-impregnated silica. The results suggest that two types of weak interactions involving the surface SiOH and B—OH groups occurred; the nitrogen atom of the amine was hydrogen bonded to surface OH and there was an interaction between OH groups and the π system of the aromatic ring. Some aniline chemisorbed on surface boron via the nitrogen atom of the amine group. Some aniline chemisorbed dissociatively to form secondary amine structures bonded through the nitrogen to surface boron atoms and new B—OH groups formed. Surface boron impurity acted as an adsorption and dissociation center.

A Review Exploring Therapeutic Worth of 1,3,4-Oxadiazole Tailored Compounds

2019 ◽  
Vol 19 (6) ◽  
pp. 477-509 ◽  
Author(s):  
Garima Verma ◽  
Mohemmed F. Khan ◽  
Wasim Akhtar ◽  
Mohammad Mumtaz Alam ◽  
Mymoona Akhter ◽  
...  
Keyword(s):  
Nitrogen Atom ◽  
Structural Feature ◽  
Aromatic Ring ◽  
Entire Range ◽  
Medicinal Chemistry ◽  
Weak Interactions ◽  
Biological Systems ◽  
Comprehensive Review ◽  
Interesting Topic ◽  
Oxadiazole Derivatives

1,3,4-Oxadiazole, a five-membered aromatic ring can be seen in a number of synthetic molecules. The peculiar structural feature of 1,3,4-oxadiazole ring with pyridine type of nitrogen atom is beneficial for 1,3,4-oxadiazole derivatives to have effective binding with different enzymes and receptors in biological systems through numerous weak interactions, thereby eliciting an array of bioactivities. Research in the area of development of 1,3,4-oxadiazole-based derivatives has become an interesting topic for the scientists. A number of 1,3,4-oxadiazole based compounds with high therapeutic potency are being extensively used for the treatment of different ailments, contributing to enormous development value. This work provides a systematic and comprehensive review highlighting current developments of 1,3,4-oxadiazole based compounds in the entire range of medicinal chemistry such as anticancer, antifungal, antibacterial, antitubercular, anti-inflammatory, antineuropathic, antihypertensive, antihistaminic, antiparasitic, antiobesity, antiviral, and other medicinal agents. It is believed that this review will be of great help for new thoughts in the pursuit for rational designs for the development of more active and less toxic 1,3,4-oxadiazole based medicinal agents.

Dipole moments of the bonds and the unshared electron pair in sulfites and sulfoxides

1969 ◽  
Vol 18 (3) ◽  
pp. 495-498
Author(s):  
L. K. Yuldasheva ◽  
R. P. Arshinova ◽  
S. G. Vul'fson
Keyword(s):  
Electron Pair ◽  
Dipole Moments ◽  
Unshared Electron Pair

Structures involving unshared electron pair. The Crystal Structures of As(OCOCH3)3 and As2O(OCOCH3)4

1993 ◽  
Vol 619 (5) ◽  
pp. 943-946 ◽  
Author(s):  
Boris Kamenar ◽  
Milenko Bruvo ◽  
Jasna Butumovi?
Keyword(s):  
Crystal Structures ◽  
Electron Pair ◽  
Unshared Electron Pair
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