Duration of the anticholinesterase effect of certain organic phosphorus compounds

1962 ◽  
Vol 52 (5) ◽  
pp. 1288-1290
Author(s):  
L. V. Donskaya ◽  
R. A. Khaunina
Keyword(s):  
Organic Phosphorus ◽  
Phosphorus Compounds

Medicinal correction of cerebrovascular reactivity — a necessary component of the treatment of cerebral blood circulation disorders

1999 ◽  
Vol 80 (2) ◽  
pp. 94-96
Author(s):  
V. I. Danilov
Keyword(s):  
Blood Circulation ◽  
Organic Phosphorus ◽  
Experimental Studies ◽  
Cerebrovascular Reactivity ◽  
Cerebral Vessels ◽  
Regulatory Mechanisms ◽  
Phosphorus Compounds ◽  
Low Toxic ◽  
The Brain ◽  
Cerebral Blood Circulation

The results of experimental studies made it possible to draw a conclusion on the reality of cerebral vessels reactivity recovery using drugs with primary neurometabolic activity, in particular, dimephosphone, sermion and pyracetam. The advantages of low-toxic nonauticholinesterasic organic phosphorus compounds among the correctors of regulatory mechanisms of circular provision of the brain are shown.

Failure of Phosphorus-32 to Exchange with Organic Phosphorus Compounds

Nature ◽  
1952 ◽  
Vol 169 (4292) ◽  
pp. 192-193 ◽  
Author(s):  
D. R. H. GOURLEY
Keyword(s):  
Organic Phosphorus ◽  
Phosphorus Compounds

scholarly journals REACTIVITY OF NUCLEOPHILES AND α-EFFECT IN SUBSTITUTION PROCESSES AT ELECTRON - DEFICIENCY CENTERS

2020 ◽  
Vol 86 (7) ◽  
Author(s):  
Anatolii Popov ◽  
Illia Kapitanov ◽  
Anna Serdyuk ◽  
Aleksandr Sumeiko
Keyword(s):  
Organic Phosphorus ◽  
Organophosphorus Pesticides ◽  
Reaction Rates ◽  
Hydroxamic Acids ◽  
Phosphorus Compounds ◽  
Reaction Products ◽  
Electron Pairs ◽  
Alkyl Derivatives ◽  
Solvent Type ◽  
Electron Deficiency

The review analyzes issues related to the reactivity of nucleophiles and the manifestation of the α-effect in substitution processes at electron-deficient centers. The fundamental aspects of this phenomenon, as well as the possibilities and prospects of using α-nucleophiles in systems for the highly efficient degradation of substrates - ecotoxicants of various natures, are discussed. In the first part of the review such aspects were observed: inorganic α-nucleophiles as the most effective class of reagents for the decomposition of organic phosphorus compounds, hydroxylamine, its N-alkyl derivatives, oximes, and hydroxamic acids, reactivity of the НОО– anion in the processes of acyl group transfer, reactivity of oximate ions, inorganic α-nucleophiles as the basis of formulations for the degradation of neurotoxins, vesicants, and organophosphorus pesticides, design of inhibited acetylcholinesterase reactivators based on hydroxylamine derivatives, ways of structural modification of α-nucleophiles and systems based on them. The data on the reactivity of typical inorganic α-nucleophiles in the cleavage of acyl-containing substrates, including phosphorus acid esters, which provide abnormally high reaction rates in comparison with other supernucleophiles, are analyzed. Various types of such α-nucleophiles, features of their structure and reactivity are considered. It was shown that an important feature of hydroxylamine, oximes, and hydroxamic acids is the presence of a fragment with adjacent O and N (–N – O – H) atoms containing one or more lone electron pairs, which determines their belonging to the class of α-nucleophiles. It has been shown that a many of factors can be responsible for the manifestation of the α-effect and its magnitude, the main of which is the destabilization of the ground state of the nucleophile due to repulsion of lone electron pairs, stabilization of the transition state, the unusual thermodynamic stability of reaction products, solvation effects of the solvent, type of hybridization of the electrophilic center, etc.

scholarly journals History of Foreign Studies of Organophosphate Induced Delayed neuropathy

2020 ◽  
Vol 4 (2) ◽  
pp. 177-188
Keyword(s):  
United States ◽  
Organic Phosphorus ◽  
Chemical Warfare Agents ◽  
The United States ◽  
Wide Distribution ◽  
Chemical Warfare ◽  
Phosphorus Compounds ◽  
Potential Threat ◽  
Delayed Neurotoxicity ◽  
Warfare Agents

Сertain organophosphates are highly toxic and can be used as chemical warfare agents. However, some classes of organic phosphorus compounds can cause so-called delayed neurotoxicity. Since the discovery of this phenomenon in 1899, extensive research has been conducted on delayed neurotoxicity caused by organophosphates. Mass poisoning of residents of the United States and Morocco in the last century demonstrated the high danger of substances that cause neurotoxicity, and gave a powerful impetus to research into this phenomenon. In addition to delayed effects, some phosphorus compounds potentiate the action of already known chemical warfare agents, increasing their toxicity by more than 10 times. Research in this direction is conducted under the auspices of the defense departments of the United States, Canada and the Netherlands. The wide distribution of phosphorus compounds in various industries and agriculture, the long hidden period and the irreversibility of lesions caused by neurotoxic organic phosphorus compounds, cause their potential threat to the security of the Russian Federation

Sheep Ked Control with Organic Phosphorus Compounds

1959 ◽  
Vol 52 (3) ◽  
pp. 539-540
Author(s):  
A. R. Roth ◽  
Walter S. Bigley
Keyword(s):  
Organic Phosphorus ◽  
Phosphorus Compounds
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