Immunochemical detection of apoprotein dissociation from very low density lipoprotein particles in human blood plasma

1992 ◽  
Vol 114 (5) ◽  
pp. 1623-1625
Author(s):  
V. V. Shuvaev ◽  
A. D. Dergunov ◽  
N. V. Perova
Keyword(s):  
Blood Plasma ◽  
Human Blood ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Human Blood Plasma ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Particles ◽  
Immunochemical Detection

scholarly journals Atherogenic modification of low-density lipoproteins

2016 ◽  
Vol 62 (4) ◽  
pp. 391-402 ◽  
Author(s):  
V.N. Sukhorukov ◽  
V.P. Karagodin ◽  
A.N. Orekhov
Keyword(s):  
Blood Plasma ◽  
Human Blood ◽  
Lipid Accumulation ◽  
Cultured Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Human Blood Plasma ◽  
Low Density ◽  
Modified Ldl ◽  
Intracellular Lipid Accumulation

One of the first manifestations of atherosclerosis is accumulation of extra- and intracellular cholesterol esters in the arterial intima. Formation of foam cells is considered as a trigger in the pathogenesis of atherosclerosis. Low density lipoprotein (LDL) circulating in human blood is the source of lipids accumulated in the arterial walls. This review considered features and role in atherogenesis different modified forms of LDL: oxidized, small dense, electronegative and especially desialylated LDL. Desialylated LDL of human blood plasma is capable to induce lipid accumulation in cultured cells and it is atherogenic. LDL possesses numerous alterations of protein, carbohydrate and lipid moieties and therefore can be termed multiple-modified LDL. Multiple modification of LDL occurs in human blood plasma and represents a cascade of successive changes in the lipoprotein particle: desialylation, loss of lipids, reduction in the particle size, increase of surface electronegative charge, etc. In addition to intracellular lipid accumulation, stimulatory effects of naturally occurring multiple-modified LDL on other processes involved in the development of atherosclerotic lesions, namely cell proliferation and fibrosis, were shown.

Atherogenic modification of low density lipoprotein by human blood plasma trans-sialidase

2001 ◽  
Vol 2 (2) ◽  
pp. 103
Author(s):  
V.V. Tertov ◽  
V.V. Kaplun ◽  
K.A. Boytsova ◽  
N.V. Bovin ◽  
A.N. Orekhov
Keyword(s):  
Blood Plasma ◽  
Human Blood ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Human Blood Plasma ◽  
Low Density
Sign in / Sign up

Export Citation Format

Share Document