Building on earlier conceptions of “metacultures,” this chapter defines four metacultures that are important for Western near-death discourse: Christian, Gnostic–Esoteric, and the Spiritualist–Occult, being religious in outlook; the fourth, however, the Naturalist metaculture, is of a nonreligious nature. The three former metacultures assign religious meaning to the content of near-death experiences, affirming by and large the soul’s survival of death. The chapter argues that this meaning has (a) ontological, (b) epistemic, (c) intersubjective or communicative, and (d) moral significance. Naturalist metaculture is defined as offering pharmacological, neurological, or psychological explanations of near-death experiences, usually declaring their content to be hallucinatory.