Three other types of duodenal polyps: Mucosal cysts, focal foveolar hyperplasia, and hyperplastic polyp originating from islands of gastric mucosa

The morphological changes in the gastric mucosa in the presence of duodenogastric reflux and refluxesophagitis and their connection with the presence of Helicobacter pylori (HP) infection are studied. The endoscopic and histological examination of the stomach antral part was performed in 1251 patients with different gastroduodenal pathologies. HP was diagnosed by histological and real-time PCR methods. Among patients with different gastroduodenal pathologies the frequency of H. pylori infection was 77.9 %. Duodenogastric reflux was detected in 23.9 % of patients. In the presence of duodenogastric reflux, we have found a decrease in the risk of duodenal ulcer by a factor of 2.5, thus duodenogastric reflux may protect against the development of duodenal ulcer. In patients with duodenogastric reflux in the presence of H. pylori infection, significant differences from the group uninfected of Helicobacter pylori were found in the metaplasia frequency. A significant increase in the frequency of foveolar hyperplasia among patients with duodenogastric reflux was revealed. The prevalence of reflux-esophagitis in the study group was 8.3 %. No increased risk in reflux-esophagitis was observed either in the HP-positive or HP-negative cases. According to our finding, duodenogastric reflux was characterized by foveolar hyperplasia and metaplasia. We suggest that the presence or absence of H. pylori does not affect reflux-esophagitis.

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Leptin and leptin receptor expression on non-ulcerated gastric mucosa, hyperplastic polyp, adenoma, and adenocarcinoma in human stomach

Gastroenterology ◽

10.1016/s0016-5085(03)81541-x ◽

2003 ◽

Vol 124 (4) ◽

pp. A306

Author(s):

Si Hong ◽

Kw Kwon ◽

Is Jung ◽

Cb Ryu ◽

Jo Kim ◽

...

Keyword(s):

Gastric Mucosa ◽

Leptin Receptor ◽

Hyperplastic Polyp ◽

Human Stomach ◽

Receptor Expression

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Why is the hyperplastic polyp a marker for the precancerous condition of the gastric mucosa?

Virchows Archiv ◽

10.1007/s00428-005-0068-2 ◽

2005 ◽

Vol 448 (1) ◽

pp. 80-84 ◽

Cited By ~ 56

Author(s):

Klaus Dirschmid ◽

Claudia Platz-Baudin ◽

Manfred Stolte

Keyword(s):

Gastric Mucosa ◽

Hyperplastic Polyp ◽

Precancerous Condition

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Hsp60 Quantification in Human Gastric Mucosa Shows Differences between Pathologies with Various Degrees of Proliferation and Malignancy Grade

Applied Sciences ◽

10.3390/app11083582 ◽

2021 ◽

Vol 11 (8) ◽

pp. 3582

Author(s):

Alessandro Pitruzzella ◽

Stefano Burgio ◽

Pietro Lo Presti ◽

Sabrina Ingrao ◽

Alberto Fucarino ◽

...

Keyword(s):

Gastric Mucosa ◽

Hyperplastic Polyp ◽

Normal Mucosa ◽

Progressive Increase ◽

Human Gastric Mucosa ◽

Hyperplastic Polyps ◽

Gastric Dysplasia ◽

Stomach Diseases ◽

The Difference ◽

Quantitative Changes

Background: Stomach diseases are an important sector of gastroenterology, including proliferative benign; premalignant; and malignant pathologies of the gastric mucosa, such as gastritis, hyperplastic polyps, metaplasia, dysplasia, and adenocarcinoma. There are data showing quantitative changes in chaperone system (CS) components in inflammatory pathologies and tumorigenesis, but their roles are poorly understood, and information pertaining to the stomach is scarce. Here, we report our findings on one CS component, the chaperone Hsp60, which we studied first considering its essential functions inside and outside mitochondria. Methods: We performed immunohistochemical experiments for Hsp60 in different samples of gastric mucosa. Results: The data obtained by quantitative analysis showed that the average percentages of Hsp60 were of 32.8 in normal mucosa; 33.5 in mild-to-moderate gastritis; 51.8 in severe gastritis; 58.5 in hyperplastic polyps; 67.0 in intestinal metaplasia; 89.4 in gastric dysplasia; and 92.5 in adenocarcinomas. Noteworthy were: (i) the difference between dysplasia and adenocarcinoma with the other pathologies; (ii) the progressive increase in Hsp60 from gastritis to hyperplastic polyp, gastric dysplasia, and gastric carcinoma; and (iii) the correlation of Hsp60 levels with histological patterns of cell proliferation and, especially, with tissue malignancy grades. Conclusions: This trend likely reflects the mounting need for cells for Hsp60 as they progress toward malignancy and is a useful indicator in differential diagnosis, as well as the call for research on the mechanisms underpinning the increase in Hsp60 and its possible roles in carcinogenesis.

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Ultrastructure Research of the Gastritis from Returning Bile

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100158558 ◽

1990 ◽

Vol 48 (3) ◽

pp. 202-203

Author(s):

Shaopeng Hu ◽

Jianhua Wang ◽

Zhen Li ◽

Huei Chen ◽

Fei Cu ◽

...

Keyword(s):

Electron Microscope ◽

Gastric Mucosa ◽

Scanning Electron Microscope ◽

Lamina Propria ◽

Transmission Electron Microscope ◽

Ultrastructural Change ◽

Common Disease ◽

Epithelial Surface ◽

Transmission Electron ◽

Scanning Electron

Gastritis from returning bile is a common disease, but the reason for the disease is not clear. As the pathologic ultrastructure research progresses, it has drawn attention to the ultrastructural change of cells in gastric mucosa by clinical workers. We observed gastric mucosa tissues of 15 patients suffering from gastritis with a transmission electron microscope (TEM) and a scanning electron microscope (SEM). It is the first report in China that fungus exists in the lamina propria of gastric mucosa tissue. The result is as follows.The gastric mucosa tissues of 15 patients suffering from gastritis were acquired by stomachoscopy. Both TEM and SEM specimens were prepared by the usual methods. Under the TEM, the epithelial surface became higher and larger. Mitochondria of the cells were swollen and cristae were disrupted. There were vacuoles in the cells. The nucleus showed disorder, heterochromatin became darker, and nucleolae could be observed.

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Sem Observations in Gastric Mucosa Exposed to Progressive Enzymatic Etching

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s1431927600002531 ◽

1980 ◽

Vol 38 ◽

pp. 570-571

Author(s):

C.A.E. Lemmi ◽

D. Booth ◽

G.E. Adomian

Keyword(s):

Gastric Mucosa ◽

Critical Point ◽

Proteolytic Activity ◽

Etching Process ◽

Cellular Types

In order to enrich populations of homogeneous cellular types we dissociated gastric mucosa by enzymatic techniques. In addition, we used SEM to monitor the progressive etching of the mucosa. Two enzymes were tested: collagenase III with minimum proteolytic activity and Pronase with broader proteolytic effects. The gastric mucosa was exposed to the effect of the enzymes using everted stomach preparations. In this way the digestive action occured progressively from the lumen of the stomach toward the base of the glands. This “etching” process could be monitored conveniently by SEM. After incubation for periods varying from 30 to 210 minutes the tissues were stretched on dental wax, fixed in 2 % glutaralheyde, post-fixed in osmium, dehydrated, critical point dryed and coated with gold. A model MSM-5 “Mini-SEM” was used for observation. Gentle uncurling of the preparation before coating with gold produced fractures which revealed the structure of the gastric glandsin more detail.

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