Scanning electron microscopic evidence for neural differentiation in Ewing's sarcoma cell lines

1990 ◽  
Vol 416 (5) ◽  
pp. 383-391 ◽  
Author(s):  
Samuel Navarro ◽  
Manuel González-Devesa ◽  
Antonio Ferrández-Izquierdo ◽  
Timothy J. Triche ◽  
Antonio Llombart-Bosch
Keyword(s):  
Cell Lines ◽  
Neural Differentiation ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Sarcoma Cell ◽  
Electron Microscopic ◽  
Microscopic Evidence ◽  
Scanning Electron Microscopic ◽  
Scanning Electron

Scanning Electron Microscopic Evidence of Spontaneous Heteropeptide Formation in Abiotic Solutions of Selected α-Amino Acid Pairs

2016 ◽  
Vol 56 (11-12) ◽  
pp. 1057-1066 ◽  
Author(s):  
Agnieszka Godziek ◽  
Anna Maciejowska ◽  
Ewa Talik ◽  
Mieczysław Sajewicz ◽  
Teresa Kowalska
Keyword(s):  
Amino Acid ◽  
Electron Microscopic ◽  
Microscopic Evidence ◽  
Scanning Electron Microscopic ◽  
Scanning Electron

scholarly journals Inhibition of heat shock proteins (HSP) expression by quercetin and differential doxorubicin sensitization in neuroblastoma and Ewing’s sarcoma cell lines

2007 ◽  
Vol 103 (4) ◽  
pp. 1344-1354 ◽  
Author(s):  
Cristina Zanini ◽  
Giuliana Giribaldi ◽  
Giorgia Mandili ◽  
Franco Carta ◽  
Nicoletta Crescenzio ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Cell Lines ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Sarcoma Cell ◽  
Shock Proteins

Scanning electron microscopic evidence for physical segmental boundaries in the anterior presomitic mesoderm

2013 ◽  
Vol 195 (5) ◽  
pp. 484-487 ◽  
Author(s):  
Qin Pu ◽  
Ketan Patel ◽  
Jürgen Berger ◽  
Bodo Christ ◽  
Ruijin Huang
Keyword(s):  
Presomitic Mesoderm ◽  
Electron Microscopic ◽  
Microscopic Evidence ◽  
Scanning Electron Microscopic ◽  
Scanning Electron

scholarly journals Discovery and Validation of a Compound to Target Ewing’s Sarcoma

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1553
Author(s):  
Ellie Esfandiari Nazzaro ◽  
Fahad Y. Sabei ◽  
Walter K. Vogel ◽  
Mohamad Nazari ◽  
Katelyn S. Nicholson ◽  
...  
Keyword(s):  
Cell Lines ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Apoptotic Cell ◽  
Intensive Therapy ◽  
Xenograft Model ◽  
Chemotherapeutic Agents ◽  
Cytotoxic Agents ◽  
Sarcoma Cell

Ewing’s sarcoma, characterized by pathognomonic t (11; 22) (q24; q12) and related chromosomal ETS family translocations, is a rare aggressive cancer of bone and soft tissue. Current protocols that include cytotoxic chemotherapeutic agents effectively treat localized disease; however, these aggressive therapies may result in treatment-related morbidities including second-site cancers in survivors. Moreover, the five-year survival rate in patients with relapsed, recurrent, or metastatic disease is less than 30%, despite intensive therapy with these cytotoxic agents. By using high-throughput phenotypic screening of small molecule libraries, we identified a previously uncharacterized compound (ML111) that inhibited in vitro proliferation of six established Ewing’s sarcoma cell lines with nanomolar potency. Proteomic studies show that ML111 treatment induced prometaphase arrest followed by rapid caspase-dependent apoptotic cell death in Ewing’s sarcoma cell lines. ML111, delivered via methoxypoly(ethylene glycol)-polycaprolactone copolymer nanoparticles, induced dose-dependent inhibition of Ewing’s sarcoma tumor growth in a murine xenograft model and invoked prometaphase arrest in vivo, consistent with in vitro data. These results suggest that ML111 represents a promising new drug lead for further preclinical studies and is a potential clinical development for the treatment of Ewing’s sarcoma.

Abstract A30: Integrative genomic analysis of two Ewing's sarcoma cell lines that show differential drug sensitivity

2014 ◽  
Author(s):  
TABREZ A. MOHAMMAD ◽  
Aparna Gorthi ◽  
Andrew Robles ◽  
Xavier Bernard ◽  
Tzu-hung Hsiao ◽  
...  
Keyword(s):  
Cell Lines ◽  
Drug Sensitivity ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Genomic Analysis ◽  
Sarcoma Cell

scholarly journals Fas-Mediated Apoptosis in Ewing's Sarcoma Cell Lines by Metalloproteinase Inhibitors

1999 ◽  
Vol 91 (19) ◽  
pp. 1678-1684 ◽  
Author(s):  
N. Mitsiades ◽  
V. Poulaki ◽  
A. Leone ◽  
M. Tsokos
Keyword(s):  
Cell Lines ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Sarcoma Cell ◽  
Metalloproteinase Inhibitors

Expression of functional Y1 receptors for neuropeptide Y in human Ewing's sarcoma cell lines

1992 ◽  
Vol 118 (7) ◽  
pp. 529-536 ◽  
Author(s):  
F. van Valen ◽  
W. Winkelmann ◽  
H. Jürgens
Keyword(s):  
Neuropeptide Y ◽  
Cell Lines ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Sarcoma Cell ◽  
Y1 Receptors

Transmission and scanning electron microscopic evidence for cytoplasmic deposition of strontium sulphate crystals in colonial radiolaria

1990 ◽  
Vol 329 (1252) ◽  
pp. 81-86 ◽  
Keyword(s):  
Surface Chemistry ◽  
Crystal Morphology ◽  
Electron Microscopic ◽  
Microscopic Evidence ◽  
Square Prism ◽  
Scanning Electron Microscopic ◽  
Biological Structures ◽  
Mineral Interfaces ◽  
Scanning Electron

Colonial radiolaria are multicellular marine protozoa (Sarcodina) that reproduce by flagellated swarmers, each containing a vacuolar-enclosed crystal of celestite (SrSO 4 ). The crystal morphology (an elongated square prism with pairs of triangular end faces) is unusual compared with crystals produced directly from solution. The crystals of radiolarian swarmers are deposited within a cytoplasmic envelope, separate from the surrounding vacuolar wall, and are subsequently enclosed by an organic coat ( ca . 500-1000 ņ thick) apparently deposited by the cytoplasmic envelope. The enclosing biological structures may account for the unusual morphology of the crystals, and offer further evidence that the process of crystallization, and ultimate crystal morphology, can be influenced markedly by surface chemistry at organo-mineral interfaces.

scholarly journals Overexpression of miR-199b-5p inhibits Ewing's sarcoma cell lines by targeting CCNL1

2015 ◽  
Vol 12 (3) ◽  
pp. 3359-3364 ◽  
Author(s):  
WEIHUA LI ◽  
YUXIA LI ◽  
JIANKUO GUO ◽  
HUAGANG PAN ◽  
YONGLE ZHANG ◽  
...  
Keyword(s):  
Cell Lines ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Sarcoma Cell

scholarly journals Let-7a Functions as a Tumor Suppressor in Ewing's Sarcoma Cell Lines Partly by Targeting Cyclin-Dependent Kinase 6

2014 ◽  
Vol 33 (3) ◽  
pp. 136-147 ◽  
Author(s):  
Zhongzu Zhang ◽  
Lu Huang ◽  
Zhiming Yu ◽  
Xiang Chen ◽  
Dong Yang ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Cell Lines ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Cyclin Dependent Kinase ◽  
Sarcoma Cell
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