Evolutionary diversification of structure and function in the family of intracellular calcium-binding proteins

1979 ◽  
Vol 13 (4) ◽  
pp. 331-352 ◽  
Author(s):  
Morris Goodman ◽  
Jean-Francois Pechére ◽  
Jacques Haiech ◽  
Jacques G. Demaille
Keyword(s):  
Intracellular Calcium ◽  
Calcium Binding ◽  
Binding Proteins ◽  
Structure And Function ◽  
Calcium Binding Proteins ◽  
Evolutionary Diversification ◽  
The Family ◽  
And Function

scholarly journals Calcium-Binding Proteins as Determinants of Central Nervous System Neuronal Vulnerability to Disease

2019 ◽  
Vol 20 (9) ◽  
pp. 2146 ◽  
Author(s):  
Richard Fairless ◽  
Sarah K. Williams ◽  
Ricarda Diem
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Intracellular Calcium ◽  
Calcium Binding ◽  
Binding Proteins ◽  
Calcium Binding Proteins ◽  
First Line ◽  
Ef Hand ◽  
Key Factor

Neuronal subpopulations display differential vulnerabilities to disease, but the factors that determine their susceptibility are poorly understood. Toxic increases in intracellular calcium are a key factor in several neurodegenerative processes, with calcium-binding proteins providing an important first line of defense through their ability to buffer incoming calcium, allowing the neuron to quickly achieve homeostasis. Since neurons expressing different calcium-binding proteins have been reported to be differentially susceptible to degeneration, it can be hypothesized that rather than just serving as markers of different neuronal subpopulations, they might actually be a key determinant of survival. In this review, we will summarize some of the evidence that expression of the EF-hand calcium-binding proteins, calbindin, calretinin and parvalbumin, may influence the susceptibility of distinct neuronal subpopulations to disease processes.

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