Intracellular calcium-binding proteins: more sites than insights

1991 ◽  
Vol 16 ◽  
pp. 98-103 ◽  
Author(s):  
Claus W. Heizmann ◽  
Willi Hunzlker
Keyword(s):  
Intracellular Calcium ◽  
Calcium Binding ◽  
Binding Proteins ◽  
Calcium Binding Proteins

scholarly journals Calcium-Binding Proteins as Determinants of Central Nervous System Neuronal Vulnerability to Disease

2019 ◽  
Vol 20 (9) ◽  
pp. 2146 ◽  
Author(s):  
Richard Fairless ◽  
Sarah K. Williams ◽  
Ricarda Diem
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Intracellular Calcium ◽  
Calcium Binding ◽  
Binding Proteins ◽  
Calcium Binding Proteins ◽  
First Line ◽  
Ef Hand ◽  
Key Factor

Neuronal subpopulations display differential vulnerabilities to disease, but the factors that determine their susceptibility are poorly understood. Toxic increases in intracellular calcium are a key factor in several neurodegenerative processes, with calcium-binding proteins providing an important first line of defense through their ability to buffer incoming calcium, allowing the neuron to quickly achieve homeostasis. Since neurons expressing different calcium-binding proteins have been reported to be differentially susceptible to degeneration, it can be hypothesized that rather than just serving as markers of different neuronal subpopulations, they might actually be a key determinant of survival. In this review, we will summarize some of the evidence that expression of the EF-hand calcium-binding proteins, calbindin, calretinin and parvalbumin, may influence the susceptibility of distinct neuronal subpopulations to disease processes.

scholarly journals Functional hydrophobic regions of intracellular calcium-binding proteins

1988 ◽  
Vol 46 ◽  
pp. 123
Author(s):  
Toshio Tanaka ◽  
Kaname Nakatani ◽  
Nobutaka Yamakawa ◽  
Joe Takai ◽  
Masaaki Ito ◽  
...  
Keyword(s):  
Intracellular Calcium ◽  
Calcium Binding ◽  
Binding Proteins ◽  
Calcium Binding Proteins
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