Colonization characteristics of a murine mammary tumor cell line that metastasizes frequently to the heart

1991 ◽  
Vol 9 (4) ◽  
pp. 351-361 ◽  
Author(s):  
A. Hossain ◽  
N. H. Sarkar
Keyword(s):  
Tumor Cell ◽  
Cell Line ◽  
Mammary Tumor ◽  
Tumor Cell Line ◽  
Mammary Tumor Cell ◽  
Mammary Tumor Cell Line ◽  
Murine Mammary Tumor

Establishment and characterization of a new murine mammary tumor cell line, balb/c-MC

1987 ◽  
Vol 23 (11) ◽  
pp. 755-758 ◽  
Author(s):  
Junji Morimoto ◽  
Shunsuke Imai ◽  
Yuzo Taniguchi ◽  
Yoshihiko Tsubura ◽  
Howard L. Hosick
Keyword(s):  
Tumor Cell ◽  
Cell Line ◽  
Mammary Tumor ◽  
Tumor Cell Line ◽  
Mammary Tumor Cell ◽  
Mammary Tumor Cell Line ◽  
Murine Mammary Tumor

scholarly journals Rosiglitazone inhibits metastasis development of a murine mammary tumor cell line LMM3

BMC Cancer ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Gabriela Magenta ◽  
Ximena Borenstein ◽  
Romina Rolando ◽  
María Adela Jasnis
Keyword(s):  
Tumor Cell ◽  
Cell Line ◽  
Mammary Tumor ◽  
Tumor Cell Line ◽  
Mammary Tumor Cell ◽  
Mammary Tumor Cell Line ◽  
Murine Mammary Tumor ◽  
Metastasis Development

scholarly journals Expression of alien H-2 and non-H-2 antigens on a murine mammary tumor cell line, MM46.

1987 ◽  
Vol 152 (1) ◽  
pp. 67-80 ◽  
Author(s):  
HARUYUKI OSHIMA ◽  
SHO ISHIKAWA ◽  
REIKO IRIE ◽  
TAKEHIKO TACHIBANA
Keyword(s):  
Tumor Cell ◽  
Cell Line ◽  
Mammary Tumor ◽  
Tumor Cell Line ◽  
Mammary Tumor Cell ◽  
Mammary Tumor Cell Line ◽  
Murine Mammary Tumor

Formation of hemidesmosomes in cells of a transformed murine mammary tumor cell line and mechanisms involved in adherence of these cells to laminin and kalinin

1993 ◽  
Vol 106 (4) ◽  
pp. 1083-1102 ◽  
Author(s):  
A. Sonnenberg ◽  
A.A. de Melker ◽  
A.M. Martinez de Velasco ◽  
H. Janssen ◽  
J. Calafat ◽  
...  
Keyword(s):  
Cell Line ◽  
Mammary Tumor ◽  
Cytochalasin B ◽  
Tumor Cell Line ◽  
Metabolic Energy ◽  
Mammary Tumor Cell ◽  
Mammary Tumor Cell Line ◽  
Murine Mammary Tumor ◽  
Integrin Alpha 6 ◽  
In Cells

Keratinocytes attach to an underlying basement membrane by adhesion junctions called hemidesmosomes. We have characterized a cell line, RAC-11P/SD, established from a murine mammary tumor, which differentiates into squamous epithelium and forms well defined hemidesmosomes. These hemidesmosomes contain the integrin alpha 6 beta 4 as well as the hemidesmosomal plaque proteins BP230 and HD1 and are associated with a matrix containing kalinin and laminin. We examined how these cells adhere to laminin and to kalinin present in matrices as well as immunopurified kalinin. We show that adhesion to laminin is energy dependent but does not require an intact actin-containing cytoskeleton. The affinity for kalinin proved to be greater and binding to kalinin was still observed when cells had been treated with deoxyglucose and azide to inhibit metabolic energy. Binding to laminin (or fragment E8), but not to kalinin was partially blocked by a monoclonal antibody specific for the integrin alpha 6 subunit, and only in the initial phase of adhesion. The antibody efficiently blocked adhesion to laminin of cells treated with the microfilament disrupting drug cytochalasin B, but only partially blocked the adhesion of cytochalasin B-treated cells to kalinin, while adherence of cells treated with deoxyglucose and azide to kalinin was blocked completely. The integrin alpha 6 beta 4 is redistributed to the basal surface during adhesion and then is organized into ring-like structures when cells are bound to laminin and localized into hemidesmosomes in cells adhered to kalinin. We suggest that anti-alpha 6 hinders the binding of the alpha 6 beta 4 integrins to its ligands laminin and kalinin, but cannot prevent adhesion when clustering of the integrin has become complete. In addition, there is evidence that adhesion to kalinin is mediated by a second receptor, which associates with the actin-containing cytoskeleton. The presence of such a second receptor is suggested because the cells can spread on kalinin, but not when they have been treated with cytochalasin B. On laminin spreading does not occur, irrespective of whether cells have been treated with cytochalasin B or not. The integrin alpha 3 beta 1, which has been identified as a receptor for kalinin but not for laminin, is strongly expressed in RAC-11P/SD cells and it seems likely that this integrin is responsible for spreading of cells on kalinin.

Abstract A10: Simultaneous block of angiogenesis through PI3K-AMPK/AKT/mTOR signaling pathways after treatment with metformin and LY294002 in canine mammary tumor cell line

2015 ◽  
Author(s):  
Marina Gobbe Moschetta ◽  
Larissa Bazela Maschio ◽  
Bruna Victorasso Jardim-Perassi ◽  
Gabriela Bottaro Gelaleti ◽  
Camila Leonel ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Signaling Pathways ◽  
Cell Line ◽  
Mammary Tumor ◽  
Tumor Cell Line ◽  
Mtor Signaling ◽  
Canine Mammary Tumor ◽  
Mammary Tumor Cell ◽  
Mammary Tumor Cell Line
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