The effect of beta adrenergic blockade on pulmonary hypertension, right ventricular hypertrophy and polycythaemia, induced in rats by intermittent high altitude hypoxia

1978 ◽  
Vol 73 (5) ◽  
pp. 422-432 ◽  
Author(s):  
B. Oštádal ◽  
J. Ressl ◽  
D. Urbanová ◽  
J. Widimský ◽  
J. Procházka ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
High Altitude ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy ◽  
Adrenergic Blockade ◽  
Beta Adrenergic ◽  
Altitude Hypoxia ◽  
High Altitude Hypoxia

Reversibility of Pulmonary Hypertension and Right Ventricular Hypertrophy Induced by Intermittent High Altitude Hypoxia in Rats

Respiration ◽  
1974 ◽  
Vol 31 (1) ◽  
pp. 38-46 ◽  
Author(s):  
J. Ressl ◽  
D. Urbanová ◽  
J. Widimský ◽  
B. Oštádal ◽  
V. Pelouch ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
High Altitude ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy ◽  
Altitude Hypoxia ◽  
High Altitude Hypoxia

Reversibility of electrophysiological changes induced by chronic high-altitude hypoxia in adult rat heart

2002 ◽  
Vol 282 (4) ◽  
pp. H1452-H1460 ◽  
Author(s):  
C. Chouabe ◽  
J. Amsellem ◽  
L. Espinosa ◽  
P. Ribaux ◽  
S. Blaineau ◽  
...  
Keyword(s):  
Right Ventricular ◽  
High Altitude ◽  
Current Density ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy ◽  
Heart Weight ◽  
Altitude Hypoxia ◽  
Altitude Exposure ◽  
High Altitude Hypoxia ◽  
The Right

Recent studies indicate that regression of left ventricular hypertrophy normalizes membrane ionic current abnormalities. This work was designed to determine whether regression of right ventricular hypertrophy induced by permanent high-altitude exposure (4,500 m, 20 days) in adult rats also normalizes changes of ventricular myocyte electrophysiology. According to the current data, prolonged action potential, decreased transient outward current density, and increased inward sodium/calcium exchange current density normalized 20 days after the end of altitude exposure, whereas right ventricular hypertrophy evidenced by both the right ventricular weight-to-heart weight ratio and the right ventricular free wall thickness measurement normalized 40 days after the end of altitude exposure. This morphological normalization occurred at both the level of muscular tissue, as shown by the decrease toward control values of some myocyte parameters (perimeter, capacitance, and width), and the level of the interstitial collagenous connective tissue. In the chronic high-altitude hypoxia model, the regression of right ventricular hypertrophy would not be a prerequisite for normalization of ventricular electrophysiological abnormalities.

Lung vascular smooth muscle as a determinant of pulmonary hypertension at high altitude

1975 ◽  
Vol 228 (3) ◽  
pp. 762-767 ◽  
Author(s):  
A Tucker ◽  
IF McMurtry ◽  
JT Reeves ◽  
AF Alexander ◽  
DH Will ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Right Ventricular ◽  
High Altitude ◽  
Ventricular Hypertrophy ◽  
Mammalian Species ◽  
Systolic Pressure ◽  
Right Ventricular Hypertrophy ◽  
Ventricular Systolic Pressure

The pulmonary hypertensive response to chronic hypoxia varies markedly among mammalian species. An explanation for this variability was sought by exposing seven species to hypobaric hypoxia (PB equal to 435 mmHg) for 19-48 days. Control animals were studied at 1,600 m (PB equal to 630 mmHg). The pulmonary hypertension that developed varied in the following order of decreasing severity: calf and pig (severe); rat and rabbit (moderate); sheep, guinea pig, and dog (mild). Right ventricular hypertrophy developed in proportion to the elevation in right ventricular systolic pressure. These interspecies variations in response were not correlated with the degree of arterial hypoxemia, degree of polycythemia, elevation in heart rate, or postnatal age. However, the medial thickness of the small pulmonary arteries in control animals was highly correlated with the development of pulmonary hypertension and right ventricular hypertrophy in hypoxic animals. Thus, the amount of lung vascular smooth muscle inherent within each species is a major determinant of the pulmonary hypertensive response to high altitude and contributes to the interspecies variability in this response.

Transient severe isolated right ventricular hypertrophy in neonates

2003 ◽  
Vol 13 (4) ◽  
pp. 384-386 ◽  
Author(s):  
Munesh Tomar ◽  
Sitaraman Radhakrishnan ◽  
Savitri Shrivastava
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Ventricular Function ◽  
Ventricular Hypertrophy ◽  
Pressure Overload ◽  
Posterior Wall ◽  
Right Ventricular Hypertrophy ◽  
Pulmonary Vasculature ◽  
Normal Thickness ◽  
The Right

We report two instances of transient isolated right-sided myocardial hypertrophy in patients with an intact ventricular septum, normal thickness of the posterior wall of the left ventricle, and normal ventricular function, diagnosed by echocardiography on the third day of life. The two neonates, born at 36 and 38 weeks gestation respectively, had perinatal distress. Both were diagnosed as having isolated right ventricular hypertrophy with mild pulmonary hypertension, which disappeared in both cases within 8 weeks without any specific therapy. Though the cause of the ventricular hypertrophy remains unclear, we believe that it is the consequence of remodeling of pulmonary vasculature secondary to acute perinatal distress, resulting in persistent pulmonary hypertension and producing pressure overload on the right ventricle, and hence right ventricular hypertrophy. The finding of early and transient right ventricular hypertrophy, with normal left-sided structures and normal ventricular function, has thus far failed to gain attention in the paediatric cardiologic literature.

scholarly journals Bosentan attenuates right ventricular hypertrophy and fibrosis in normobaric hypoxia model of pulmonary hypertension

2011 ◽  
Vol 30 (7) ◽  
pp. 827-833 ◽  
Author(s):  
Gaurav Choudhary ◽  
Frederick Troncales ◽  
Douglas Martin ◽  
Elizabeth O. Harrington ◽  
James R. Klinger
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy ◽  
Normobaric Hypoxia

scholarly journals Progressive Development of Pulmonary Hypertension Leading to Right Ventricular Hypertrophy Assessed by Echocardiography in Rats.

2003 ◽  
Vol 52 (4) ◽  
pp. 285-294 ◽  
Author(s):  
Yosuke KATO ◽  
Mitsunori IWASE ◽  
Hiroaki KANAZAWA ◽  
Natsuki KAWATA ◽  
Yukie YOSHIMORI ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy ◽  
Progressive Development

scholarly journals Cardiomyocyte-Specific Overexpression of HEXIM1 Prevents Right Ventricular Hypertrophy in Hypoxia-Induced Pulmonary Hypertension in Mice

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52522 ◽  
Author(s):  
Noritada Yoshikawa ◽  
Noriaki Shimizu ◽  
Takako Maruyama ◽  
Motoaki Sano ◽  
Tomohiro Matsuhashi ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy
Sign in / Sign up

Export Citation Format

Share Document