Effects of repeated indomethacin administration on cerebral oxygenation and haemodynamics in preterm infants: Combined near infrared spectrophotometry and Doppler ultrasound study

1994 ◽  
Vol 153 (7) ◽  
pp. 504-509 ◽  
Author(s):  
K. D. Liem ◽  
J. C. W. Hopman ◽  
L. A. A. Kollée ◽  
B. Oeseburg
Keyword(s):  
Preterm Infants ◽  
Doppler Ultrasound ◽  
Near Infrared ◽  
Cerebral Oxygenation ◽  
Infrared Spectrophotometry ◽  
Ultrasound Study

scholarly journals The Influence of Sodium Bicarbonate on Cerebral Oxygenation and Hemodynamics in Preterm Infants Investigated Using Near Infrared Spectrophotometry (NIRS)

1999 ◽  
Vol 45 (6) ◽  
pp. 906-906
Author(s):  
K D Liem ◽  
E J Kroes ◽  
AAEM Van Der Velden ◽  
JHGM Klaessens ◽  
M Van De Bor
Keyword(s):  
Sodium Bicarbonate ◽  
Preterm Infants ◽  
Near Infrared ◽  
Cerebral Oxygenation ◽  
Infrared Spectrophotometry

Regional differences of cerebral hemoglobin concentration in preterm infants measured by near infrared spectrophotometry

1999 ◽  
Vol 7 (1) ◽  
pp. 63-73 ◽  
Author(s):  
Matthias Keel ◽  
Martin Wolf ◽  
Oskar Baenziger ◽  
Vera Dietz ◽  
Kurt von Siebenthal ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Regional Differences ◽  
Near Infrared ◽  
Hemoglobin Concentration ◽  
Infrared Spectrophotometry

The Effect of Antenatal Neuroprotective Magnesium Sulfate Treatment on Cerebral Oxygenation in Preterm Infants

2020 ◽  
Author(s):  
Buse Ozer Bekmez ◽  
Yüksel Oğuz ◽  
Hayriye Gözde Kanmaz Kutman ◽  
Dilek Uygur ◽  
Fuat Emre Canpolat ◽  
...  
Keyword(s):  
Magnesium Sulfate ◽  
Preterm Infants ◽  
Near Infrared ◽  
Cerebral Oxygenation ◽  
Postnatal Life ◽  
Regional Cerebral Oxygen Saturation ◽  
Future Studies ◽  
The Third ◽  
Early Postnatal Life ◽  
Underlying Mechanisms

Abstract Objective Antenatal magnesium sulfate (MgSO4) treatment is associated with reduced risk of cerebral palsy in preterm infants. We aimed to investigate whether this treatment leads to any alterations on cerebral hemodynamics which could be detected by near-infrared spectroscopy (NIRS) readings in early postnatal life. Study design Infants with gestational ages (GAs) ≤ 32 weeks were divided into two groups regarding their exposure to antenatal neuroprotective MgSO4 treatment or not. NIRS monitoring was performed to all infants, and readings were recorded for 2 hours each day during the first 3 days of life. The primary aim was to compare regional cerebral oxygen saturation (rcSO2) and cerebral fractional tissue oxygen extraction (cFTOE) between the groups. Results Sixty-six infants were exposed to antenatal MgSO4, while 64 of them did not. GA and birth weight were significantly lower in the treatment group (p < 0.01). No difference was observed in rcSO2 and cFTOE levels in the first, second, and the third days of life (p > 0.05). An insignificant reduction in severe intraventricular hemorrhage rates was observed (8 vs. 15%, p = 0.24). Conclusion We could not demonstrate any effect on cerebral oxygenation of preterm infants in early postnatal life that could be attributed to antenatal neuroprotective MgSO4 treatment. Future studies are warranted to clarify the exact underlying mechanisms of neuroprotection.

The effect of blood transfusion and haemodilution on cerebral oxygenation and haemodynamics in newborn infants investigated by near infrared spectrophotometry

1997 ◽  
Vol 156 (4) ◽  
pp. 305-310 ◽  
Author(s):  
K. D. Liem ◽  
J. C. W. Hopman ◽  
B. Oeseburg ◽  
A. F. J. de Haan ◽  
L. A. A. Kollée
Keyword(s):  
Blood Transfusion ◽  
Near Infrared ◽  
Cerebral Oxygenation ◽  
Newborn Infants ◽  
Infrared Spectrophotometry

Effects of Single Loading Dose of Intravenous Caffeine on Cerebral Oxygenation in Preterm Infants

2020 ◽  
Author(s):  
Ozkan Ilhan ◽  
Meltem Bor
Keyword(s):  
Preterm Infants ◽  
Near Infrared ◽  
Cerebral Oxygenation ◽  
Clinical Importance ◽  
Oxygen Extraction ◽  
Loading Dose ◽  
Tissue Oxygen ◽  
Cerebral Tissue ◽  
Baseline Values ◽  
A Prospective Study

Abstract Objective The aim of this study was to evaluate the effects of caffeine on cerebral oxygenation in preterm infants. Study Design This was a prospective study of infants with a gestational age (GA) of < 34 weeks who were treated intravenously with a loading dose of 20 mg/kg caffeine citrate within the first 48 hours of life. Regional cerebral oxygen saturation (rSO2C) and cerebral fractional tissue oxygen extraction (cFTOE) were measured using near-infrared spectroscopy before administering caffeine (baseline), immediately after administering caffeine, and 1, 2, 3, 4, 6, and 12 hours after dose completion; postdose values were compared with the baseline values. Results A total of 48 infants with a mean GA of 29.0 ± 1.9 weeks, birth weight of 1,286 ± 301 g, and postnatal age of 32.4 ± 11.3 hours were included in the study. rSO2C significantly decreased from 81.3 to 76.7% soon after administering caffeine, to 77.1% at 1 hour, and to 77.8% at 2 hours with recovery at 3 hours postdose. rSO2C was 80.2% at 12 hours postdose. cFTOE increased correspondingly. Although rSO2C values were lower and cFTOE values were higher compared with the baseline values at 3, 4, 6, and 12 hours after caffeine administration, this was not statistically significant. Conclusion A loading dose of caffeine temporarily reduces cerebral oxygenation and increases cerebral tissue oxygen extraction in preterm infants. Most probably these changes reflect a physiological phenomenon without any clinical importance to the cerebral hemodynamics, as the reduction in cerebral oxygenation and increase in cerebral tissue oxygen extraction remain well within acceptable range.

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