Effects of histamine, H2, H2 and Hic receptor antagonists andα-fluoromethylhistidine on the growth of human colorectal cancer in the subrenal capsule assay

1994 ◽  
Vol 41 (S1) ◽  
pp. C118-C120 ◽  
Author(s):  
E. Suonio ◽  
L. Tuomisto ◽  
E. Alhava
Keyword(s):  
Colorectal Cancer ◽  
Human Colorectal Cancer ◽  
Receptor Antagonists ◽  
Subrenal Capsule Assay ◽  
Subrenal Capsule

Increased Farnesyltransferase Activity in Human Colorectal Cancer: Relationship with Clinicopathological Features and K-ras Mutation

2003 ◽  
Vol 38 (1) ◽  
pp. 80-85 ◽  
Author(s):  
M. G. Caruso ◽  
Notarnicola M. ◽  
Bifulco M. ◽  
Laezza C. ◽  
Guerra V. ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinicopathological Features ◽  
Human Colorectal Cancer ◽  
Ras Mutation

Expression of chemokine receptor CCR5 correlates with the presence of hepatic molecular metastases in K-ras positive human colorectal cancer

2011 ◽  
Vol 49 (08) ◽  
Author(s):  
CC Schimanski ◽  
M Möhler ◽  
I Gockel ◽  
T Zimmermann ◽  
H Lang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Chemokine Receptor ◽  
Human Colorectal Cancer ◽  
Chemokine Receptor Ccr5 ◽  
Receptor Ccr5

COX-2/PGE2 regulates VEGF expression by activating Wnt/β-catenin signal pathway in human colorectal cancer cells

2013 ◽  
Vol 32 (11) ◽  
pp. 1178-1181
Author(s):  
Xuan LIU ◽  
Dan-guang LI ◽  
Li-hong ZHOU ◽  
Yan WANG ◽  
Pei-hao YIN ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Signal Pathway ◽  
Human Colorectal Cancer ◽  
Vegf Expression ◽  
Colorectal Cancer Cells ◽  
Cox 2 ◽  
Human Colorectal Cancer Cells

Bioactive Peptides Sensitize Cells to Anticancer Effects of Oxaliplatin in Human Colorectal Cancer Xenografts in Nude Mice

2019 ◽  
Vol 26 (7) ◽  
pp. 512-522
Author(s):  
Xian Li ◽  
Long Xia ◽  
Xiaohui Ouyang ◽  
Qimuge Suyila ◽  
Liya Su ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Nude Mice ◽  
Low Dose ◽  
Bioactive Peptides ◽  
Human Colorectal Cancer ◽  
Short Term ◽  
Hct 116

<P>Background: Despite new agent development and short-term benefits in patients with Colorectal Cancer (CRC), metastatic CRC cure rates have not improved due to high rates of oxaliplatin resistance and toxicity. There is an urgent need for effective tools to prevent and treat CRC and reduce morbidity and mortality of CRC patients. Exploring the effects of bioactive peptides on the antitumor to CRC was of vital importance to the clinical application. </P><P> Objective: This study aimed to investigate the therapeutic impact of Anticancer Bioactive Peptides (ACBP) on anticancer effect of oxaliplatin (LOHP) in human colorectal cancer xenografts models in nude mice. </P><P> Methods: HCT-116 cells were cultured in vitro via CCK-8 assays and the absorbance was measured at 450 nm. Apoptosis and cell cycle were assessed by Flow Cytometry (FCM) in vitro. HCT-116 human colorectal cancer cells inoculated subcutaneously in nude mice of treatment with PBS (GG), ACBP, LOHP, ACBP+LOHP (A+L) in vivo. The quality of life was assessed by dietary amount of nude mice, the weight of nude mice, inhibition rates, tumor weight and tumor volume. Immunohistochemistry and RT-qPCR method was conducted to determine the levels of apoptosisregulating proteins/genes in transplanted tumors. </P><P> Results: ACBP induced substantial reductions in viable cell numbers and apoptosis of HCT116 cells in combined with LOHP in vitro. Compared with the control GG group, ACBP combined low dose oxaliplatin (U) group demonstrated significantly different tumor volume, the rate of apoptosis, the expression levels of Cyt-C, caspase-3,8,9 proteins and corresponding RNAs (P<0.05). The expression of pro-apoptotic proteins in the cytoplasm around the nucleus was significantly enhanced by ACBP. Short term intermittent use of ACBP alone indicted a certain inhibitory effect on tumor growth, and improve the quality of life of tumor bearing nude mice. </P><P> Conclusion: ACBP significantly increased the anti-cancer responses of low dose oxaliplatin (L-LOHP), thus, significantly improving the quality of life of tumor-bearing nude mice.</P>

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