The brain specific proteins S100 and 14.3.2 in experimental brain tumors of the rat

1971 ◽  
Vol 156 (3) ◽  
pp. 237-242 ◽  
Author(s):  
D. Stavrou ◽  
K. G. Haglid ◽  
W. Weidenbach
Keyword(s):  
Brain Tumors ◽  
Experimental Brain Tumors ◽  
Specific Proteins ◽  
Brain Specific Proteins ◽  
The Brain

An immunological study of human brain tumors concerning the brain specific proteins S-100 and 14.3.2

1973 ◽  
Vol 24 (3) ◽  
pp. 187-196 ◽  
Author(s):  
K. Haglid ◽  
C. -A. Carlsson ◽  
D. Stavrou
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Immunological Study ◽  
Human Brain Tumors ◽  
S 100 ◽  
Specific Proteins ◽  
Brain Specific Proteins ◽  
The Brain

Binding of concanavalin A to the brain-specific proteins obtained from human white matter by affinity chromatography

1975 ◽  
Vol 24 (4) ◽  
pp. 805-806 ◽  
Author(s):  
E. G. Brunngraber ◽  
J. P. Susz ◽  
J. Javaid ◽  
A. Aro ◽  
K. Warecka
Keyword(s):  
White Matter ◽  
Affinity Chromatography ◽  
Concanavalin A ◽  
Specific Proteins ◽  
Brain Specific Proteins ◽  
The Brain

The levels of the brain-specific proteins, S-100 and 14-3-2, in the developing chick spinal cord

1972 ◽  
Vol 44 (1) ◽  
pp. 294-298 ◽  
Author(s):  
T.J. Cicero ◽  
Provine R.R.
Keyword(s):  
Spinal Cord ◽  
S 100 ◽  
Specific Proteins ◽  
Brain Specific Proteins ◽  
The Brain ◽  
Chick Spinal Cord

Simple sequence in brain and nervous system specific proteins

Genome ◽  
2005 ◽  
Vol 48 (2) ◽  
pp. 291-301 ◽  
Author(s):  
Melanie A Huntley ◽  
Sanaa Mahmood ◽  
G Brian Golding
Keyword(s):  
Nervous System ◽  
Repetitive Sequences ◽  
Neurological Function ◽  
Expression Data ◽  
Specific Expression ◽  
Amino Acid Repeats ◽  
Specific Proteins ◽  
Brain Specific Proteins ◽  
The Brain ◽  
Simple Sequence

We examined sequences expressed in the brain and nervous system using EST data. A previous study including sequences thought to have neurological function found a deficiency of simple sequence within such sequences. This was despite many examples of neurodegenerative diseases, such as Huntington disease, which are thought to be caused by expansions of polyglutamine tracts within associated protein sequences. It may be that many of the sequences thought to have neurological function have other additional, non-neurological roles. For this reason, we examined sequences with specific expression in the brain and nervous system, using EST expression data to determine if they too are deficient of simple, repetitive sequences. Indeed, we find this class of sequences to be deficient. Unexpectedly, however, we find sequences expressed in the brain and nervous system to be consistently enriched for histidine-enriched simple sequence. Determining the function of these histidine-rich regions within brain-specific proteins requires more experimental data.Key words: amino acid repeats, homopeptides, simple sequence, triplet repeat diseases, nervous system proteins, brain-specific proteins.

scholarly journals The brain-specific proteins D1, D2 and D3 in the cerebellum of staggerer, reeler and weaver mutant mice

FEBS Letters ◽  
1978 ◽  
Vol 93 (2) ◽  
pp. 185-188 ◽  
Author(s):  
Ole Steen Jørgensen ◽  
Kotsuhiko Mikoshiba
Keyword(s):  
Mutant Mice ◽  
Specific Proteins ◽  
Brain Specific Proteins ◽  
The Brain

scholarly journals Production and characterization of monoclonal antibodies against the "brain-specific" proteins 14-3-2 and S-100.

1982 ◽  
Vol 79 (23) ◽  
pp. 7585-7589 ◽  
Author(s):  
E. A. Haan ◽  
B. D. Boss ◽  
W. M. Cowan
Keyword(s):  
Monoclonal Antibodies ◽  
S 100 ◽  
Specific Proteins ◽  
Brain Specific Proteins ◽  
The Brain

Brain Tumor Detection via Asymmetry Quantification across Mid Sagittal Plane

2020 ◽  
Vol 13 ◽  
Author(s):  
Shoaib Amin Banday ◽  
Mohammad Khalid Pandit
Keyword(s):  
Brain Tumor ◽  
Brain Tumors ◽  
Sagittal Plane ◽  
Early Stage ◽  
Imaging Techniques ◽  
Complex Structure ◽  
Magnetic Resonance Images ◽  
Absolute Difference ◽  
Brain Hemispheres ◽  
The Brain

Introduction: Brain tumor is among the major causes of morbidity and mortality rates worldwide. According to National Brain Tumor Foundation (NBTS), the death rate has nearly increased by as much as 300% over last couple of decades. Tumors can be categorized as benign (non-cancerous) and malignant (cancerous). The type of the brain tumor significantly depends on various factors like the site of its occurrence, its shape, the age of the subject etc. On the other hand, Computer Aided Detection (CAD) has been improving significantly in recent times. The concept, design and implementation of these systems ascend from fairly simple ones to computationally intense ones. For efficient and effective diagnosis and treatment plans in brain tumor studies, it is imperative that an abnormality is detected at an early stage as it provides a little more time for medical professionals to respond. The early detection of diseases has predominantly been possible because of medical imaging techniques developed from past many decades like CT, MRI, PET, SPECT, FMRI etc. The detection of brain tumors however, has always been a challenging task because of the complex structure of the brain, diverse tumor sizes and locations in the brain. Method: This paper proposes an algorithm that can detect the brain tumors in the presence of the Radio-Frequency (RF) inhomoginiety. The algorithm utilizes the Mid Sagittal Plane as a landmark point across which the asymmetry between the two brain hemispheres is estimated using various intensity and texture based parameters. Result: The results show the efficacy of the proposed method for the detection of the brain tumors with an acceptable detection rate. Conclusion: In this paper, we have calculated three textural features from the two hemispheres of the brain viz: Contrast (CON), Entropy (ENT) and Homogeneity (HOM) and three parameters viz: Root Mean Square Error (RMSE), Correlation Co-efficient (CC), and Integral of Absolute Difference (IAD) from the intensity distribution profiles of the two brain hemispheres to predict any presence of the pathology. First a Mid Sagittal Plane (MSP) is obtained on the Magnetic Resonance Images that virtually divides brain into two bilaterally symmetric hemispheres. The block wise texture asymmetry is estimated for these hemispheres using the above 6 parameters.

scholarly journals Beyond Oncological Hyperthermia: Physically Drivable Magnetic Nanobubbles as Novel Multipurpose Theranostic Carriers in the Central Nervous System

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2104 ◽  
Author(s):  
Eleonora Ficiarà ◽  
Shoeb Anwar Ansari ◽  
Monica Argenziano ◽  
Luigi Cangemi ◽  
Chiara Monge ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Tumors ◽  
Ad Hoc ◽  
Superparamagnetic Iron Oxide ◽  
Conventional Radiotherapy ◽  
The Central Nervous System ◽  
Magnetic Resonance Imaging Mri ◽  
The Brain

Magnetic Oxygen-Loaded Nanobubbles (MOLNBs), manufactured by adding Superparamagnetic Iron Oxide Nanoparticles (SPIONs) on the surface of polymeric nanobubbles, are investigated as theranostic carriers for delivering oxygen and chemotherapy to brain tumors. Physicochemical and cyto-toxicological properties and in vitro internalization by human brain microvascular endothelial cells as well as the motion of MOLNBs in a static magnetic field were investigated. MOLNBs are safe oxygen-loaded vectors able to overcome the brain membranes and drivable through the Central Nervous System (CNS) to deliver their cargoes to specific sites of interest. In addition, MOLNBs are monitorable either via Magnetic Resonance Imaging (MRI) or Ultrasound (US) sonography. MOLNBs can find application in targeting brain tumors since they can enhance conventional radiotherapy and deliver chemotherapy being driven by ad hoc tailored magnetic fields under MRI and/or US monitoring.

scholarly journals Laser interstitial thermotherapy (LITT) for the treatment of tumors of the brain and spine: a brief review

2021 ◽  
Vol 151 (3) ◽  
pp. 429-442
Author(s):  
Clark Chen ◽  
Ian Lee ◽  
Claudio Tatsui ◽  
Theresa Elder ◽  
Andrew E. Sloan
Keyword(s):  
Brain Tumors ◽  
Minimally Invasive ◽  
Radiation Necrosis ◽  
Spinal Metastasis ◽  
Clinical Approach ◽  
Invasive Treatment ◽  
Primary Indication ◽  
Interstitial Thermotherapy ◽  
The Brain

Abstract Introduction Laser Interstitial Thermotherapy (LITT; also known as Stereotactic Laser Ablation or SLA), is a minimally invasive treatment modality that has recently gained prominence in the treatment of malignant primary and metastatic brain tumors and radiation necrosis and studies for treatment of spinal metastasis has recently been reported. Methods Here we provide a brief literature review of the various contemporary uses for LITT and their reported outcomes. Results Historically, the primary indication for LITT has been for the treatment of recurrent glioblastoma (GBM). However, indications have continued to expand and now include gliomas of different grades, brain metastasis (BM), radiation necrosis (RN), other types of brain tumors as well as spine metastasis. LITT is emerging as a safe, reliable, minimally invasive clinical approach, particularly for deep seated, focal malignant brain tumors and radiation necrosis. The role of LITT for treatment of other types of tumors of the brain and for spine tumors appears to be evolving at a small number of centers. While the technology appears to be safe and increasingly utilized, there have been few prospective clinical trials and most published studies combine different pathologies in the same report. Conclusion Well-designed prospective trials will be required to firmly establish the role of LITT in the treatment of lesions of the brain and spine.

Role of miRNA in distinguishing primary brain tumors from secondary tumors metastatic to the brain

10.2741/201 ◽  
2011 ◽  
Vol S3 (1) ◽  
pp. 970 ◽  
Author(s):  
Matteo Fassan
Keyword(s):  
Brain Tumors ◽  
Primary Brain Tumors ◽  
Secondary Tumors ◽  
The Brain
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