Effect of calcitonin on plasma glucose, C-peptide, glucagon and growth hormone responses to arginine in insulin-dependent diabetic subjects

1981 ◽  
Vol 18 (3) ◽  
pp. 235-241 ◽  
Author(s):  
Saverio Sgambato ◽  
Nicola Passariello ◽  
Dario Giugliano ◽  
Roberto Torella ◽  
Felice D'Onofrio
Keyword(s):  
Growth Hormone ◽  
Plasma Glucose ◽  
C Peptide ◽  
Insulin Dependent ◽  
Hormone Responses ◽  
Insulin Dependent Diabetic

Effects of acetylsalicylic acid on plasma glucose, free fatty acid, betahydroxybutyrate, glucagon and c-peptide responses to salbutamol in insulin-dependent diabetic subjects

1981 ◽  
Vol 18 (1) ◽  
pp. 27-36 ◽  
Author(s):  
Dario Giugliano ◽  
Teresa Cerciello ◽  
Nicola Passariello ◽  
Michele Varricchio ◽  
Roberto Torella ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Acetylsalicylic Acid ◽  
Plasma Glucose ◽  
C Peptide ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Glucoregulation and hormonal responses to maximal exercise in non-insulin-dependent diabetes

1990 ◽  
Vol 68 (5) ◽  
pp. 2067-2074 ◽  
Author(s):  
M. Kjaer ◽  
C. B. Hollenbeck ◽  
B. Frey-Hewitt ◽  
H. Galbo ◽  
W. Haskell ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Maximal Exercise ◽  
Glucose Production ◽  
Dynamic Exercise ◽  
Glucose Disposal ◽  
Hormonal Responses ◽  
Insulin Effect ◽  
Glucose Levels ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Maximal dynamic exercise results in a postexercise hyperglycemia in healthy young subjects. We investigated the influence of maximal exercise on glucoregulation in non-insulin-dependent diabetic subjects (NIDDM). Seven NIDDM and seven healthy control males bicycled 7 min at 60% of their maximal O2 consumption (VO2max), 3 min at 100% VO2max, and 2 min at 110% VO2max. In both groups, glucose production (Ra) increased more with exercise than did glucose uptake (Rd) and, accordingly, plasma glucose increased. However, in NIDDM subjects the increase in Ra was hastened and Rd inhibited compared with controls, so the increase in glucose occurred earlier and was greater [147 +/- 21 to 169 +/- 19 (30 min postexercise) vs. 90 +/- 4 to 100 +/- 5 (SE) mg/dl (10 min postexercise), P less than 0.05]. Glucose levels remained elevated for greater than 60 min postexercise in both groups. Glucose clearance increased during exercise but decreased postexercise to or below (NIDDM, P less than 0.05) basal levels, despite increased insulin levels (P less than 0.05). Plasma epinephrine and glucagon responses to exercise were higher in NIDDM than in control subjects (P less than 0.05). By use of the insulin clamp technique at 40 microU.m-2.min-1 of insulin with plasma glucose maintained at basal levels, glucose disposal in NIDDM subjects, but not in controls, was enhanced 24 h after exercise. It is concluded that, because of exaggerated counter-regulatory hormonal responses, maximal dynamic exercise results in a 60-min period of postexercise hyperglycemia and hyperinsulinemia in NIDDM. However, this event is followed by a period of increased insulin effect on Rd that is present 24 h after exercise.(ABSTRACT TRUNCATED AT 250 WORDS)

Plasma C-peptide response to arginine in insulin-dependent diabetic subjects

1980 ◽  
Vol 3 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Dario Giugliano ◽  
A. S. Luyckx ◽  
P. J. Lefebvre
Keyword(s):  
C Peptide ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Nocturnal versus diurnal hormonal counterregulation to hypoglycemia in Type 1 (insulin-dependent) diabetic patients

1993 ◽  
Vol 128 (2) ◽  
pp. 109-115 ◽  
Author(s):  
Inger Bendtson ◽  
Anne Mette Rosenfalck ◽  
Christian Binder
Keyword(s):  
Growth Hormone ◽  
Blood Glucose ◽  
Insulin Infusion ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Diabetic Patients ◽  
Hormonal Responses ◽  
Nocturnal Hypoglycemia ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Asymptomatic hypoglycemia in IDDM patients seems to be more frequent during the night than during the day, with reported frequencies as high as 56%. Hormonal counterregulation to diurnal and nocturnal hypoglycemia was studied in 10 insulin-dependent diabetic patients without diabetic complications in order to test whether hormonal responses were lower at night than during daytime. A lower catecholamine response might imply less marked symptoms and therefore one reason why patients are not awakened by hypoglycemia. Blood glucose was stabilized to around 6 mmol/1 by iv insulin infusion and hypoglycemia was induced by increasing the insulin infusion rate—in the night studies at 01.30, in the day studies at 08.00. Blood glucose nadirs were 1.5±0.4 (1.2–1.9) mmol/1 at night and 1.9±0.3 (1.3–2.2) mmol/l during the day; in three patients the nadirs were identical during both the night and day. One patient had no adrenaline response to daytime hypoglycemia. In general, nocturnal hypoglycemia elicited greater catecholamine responses correlated to the duration of hypoglycemia. Glucagon responses showed a great heterogeneity independently of diabetes duration and hypoglycemic level. Growth hormone secretion was reduced during the night study; however, no refractory periods were found after sleep-related growth hormone secretion. In conclusion: counter-regulatory hormonal responses tend to be greater at night than during the day and do not explain why patients are not awakened by nocturnal hypoglycemia.

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