Effects of acetylsalicylic acid on plasma glucose, free fatty acid, betahydroxybutyrate, glucagon and c-peptide responses to salbutamol in insulin-dependent diabetic subjects

1981 ◽  
Vol 18 (1) ◽  
pp. 27-36 ◽  
Author(s):  
Dario Giugliano ◽  
Teresa Cerciello ◽  
Nicola Passariello ◽  
Michele Varricchio ◽  
Roberto Torella ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Acetylsalicylic Acid ◽  
Plasma Glucose ◽  
C Peptide ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Lack of effect of hyperglycemia on lipolysis in humans

1993 ◽  
Vol 265 (6) ◽  
pp. E821-E824 ◽  
Author(s):  
E. Cersosimo ◽  
S. Coppack ◽  
M. Jensen
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Plasma Glucose ◽  
Acid Metabolism ◽  
The Face ◽  
Study Interval ◽  
Free Fatty Acid Metabolism ◽  
Insulin Dependent ◽  
Adipose Tissue Lipolysis

To examine whether hyperglycemia is an independent regulator of adipose tissue lipolysis, we measured palmitate flux ([3H]palmitate) on two occasions in eight volunteers with insulin-dependent diabetes. On one. occasion, euglycemia was maintained for 4 h continuously; on a different occasion, hyperglycemia (plasma glucose, 12 mmol/l) was induced after 2 h of euglycemia. Palmitate flux decreased from 1.39 +/- 0.22 to 1.25 +/- 0.18 mumol.kg-1 x min-1 during sustained euglycemia and from 1.43 +/- 0.24 to 1.13 +/- 0.19 mumol.kg-1 x min-1 during the transition from the euglycemic to the hyperglycemic study intervals. There were no significant differences between the changes in palmitate flux from the first to the second study interval on the control (euglycemia-euglycemia) and experimental (euglycemia-hyperglycemia) study days and no difference between palmitate flux on different study days. Thus, in the face of euinsulinemia, euglucagonemia, and the absence of somatostatin, no effect of hyperglycemia on free fatty acid metabolism could be detected in humans.

Lack of effect of hyperglycemia on lipolysis in humans

1990 ◽  
Vol 259 (4) ◽  
pp. E542-E547
Author(s):  
M. Caruso ◽  
G. D. Divertie ◽  
M. D. Jensen ◽  
J. M. Miles
Keyword(s):  
Growth Hormone ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Plasma Glucose ◽  
Time Dependent ◽  
Constant Infusion ◽  
Insulin Dependent ◽  
Adipose Tissue Lipolysis ◽  
Per Se

Controversy exists regarding whether plasma glucose concentrations are independently involved in the regulation of adipose tissue lipolysis. In the present study, six subjects with insulin-dependent diabetes and six nondiabetic volunteers were studied during infusion of somatostatin, growth hormone, and insulin at rates designed to maintain basal rates of lipolysis, which was traced using a constant infusion of [1-14C]palmitate. A euglycemic (approximately 5 mmol/l) clamp was performed for 3 h, followed by 3 h of hyperglycemia (approximately 9 and approximately 11 mmol/l in nondiabetic and diabetic subjects, respectively). Ten nondiabetic subjects were studied during 6 h of euglycemia to exclude time-dependent changes in lipolysis. The results showed that palmitate concentrations did not change between euglycemia and hyperglycemia in either group [118 +/- 10 vs. 132 +/- 14 mumol/l and 145 +/- 21 vs. 134 +/- 15 mumol/l in nondiabetic and diabetic subjects, respectively; both P = not significant (NS)]. Similarly, palmitate rate of appearance (Ra) did not change during hyperglycemia (1.0 +/- 0.1 and 1.7 +/- 0.4 mumol.kg-1.min-1 in nondiabetic and diabetic subjects, respectively) compared with euglycemia (1.0 +/- 0.1 and 1.6 +/- 0.4 mumol.kg-1.min-1 in nondiabetic and diabetic subjects, respectively; P = NS). Palmitate concentrations and Ra did not change during 6 h of euglycemia in nondiabetic volunteers. Thus hyperglycemia per se has no effect on free fatty acid turnover. Changes in lipolysis that occur coincident with hyperglycemia are probably due to changes in other circulating substrates or hormones known to affect lipolysis.

Effect of calcitonin on plasma glucose, C-peptide, glucagon and growth hormone responses to arginine in insulin-dependent diabetic subjects

1981 ◽  
Vol 18 (3) ◽  
pp. 235-241 ◽  
Author(s):  
Saverio Sgambato ◽  
Nicola Passariello ◽  
Dario Giugliano ◽  
Roberto Torella ◽  
Felice D'Onofrio
Keyword(s):  
Growth Hormone ◽  
Plasma Glucose ◽  
C Peptide ◽  
Insulin Dependent ◽  
Hormone Responses ◽  
Insulin Dependent Diabetic

Effect of prolonged overnight fasting on energy metabolism in non-insulin-dependent diabetic and non-diabetic subjects

1990 ◽  
Vol 123 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Leif C. Groop ◽  
Riccardo Bonadonna ◽  
Stefano DelPrato ◽  
Klaus Ratheiser ◽  
Ralph A. DeFronzo
Keyword(s):  
Fatty Acid ◽  
Energy Metabolism ◽  
Free Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Plasma Glucose ◽  
Plasma Free Fatty Acid ◽  
Acid Oxidation ◽  
Free Fatty Acid Oxidation ◽  
Insulin Dependent ◽  
Overnight Fasting

Abstract. The effect on energy metabolism of a 6-h prolongation of the conventional 12-h overnight fast was examined in 9 healthy subjects and in 7 patients with non-insulin-dependent diabetes mellitus. Plasma glucose concentration decreased by 7 and 23%, in control and diabetic subjects, respectively. In control subjects, the fall in plasma glucose was associated with a slight but significant fall in plasma insulin and a rise in plasma free fatty acid concentrations. During this same period, the rates of plasma free fatty acid oxidation, measured by infusion of [14C]palmitate, and net lipid oxidation, measured by indirect calorimetry, increased in normal subjects by 55 and 76%, respectively; the rate of glucose oxidation measured by indirect calorimetry decreased by 37%. In the diabetic patients, the free fatty acid oxidation rate was enhanced already after 12 h of fasting compared with controls (2.06 vs 1.30 μmol · kg−1 · min−1; p<0.05) and did not change significantly during the 6-h observation period. After 18 h of fasting, the rate of plasma free fatty acid oxidation was similar in control and diabetic subjects. The data thus emphasize the need for strict standardization of the overnight fasting period for metabolic studies, and demonstrate the difficulties in comparing basal rates of substrate oxidation between healthy and diabetic subjects.

scholarly journals Effect of alcohol on glucose, insulin, free fatty acid and triacylglycerol responses to a light meal in non-insulin-dependent diabetic subjects

1994 ◽  
Vol 71 (3) ◽  
pp. 449-454 ◽  
Author(s):  
Christian Christiansen ◽  
Claus Thomsen ◽  
Ole Rasmussen ◽  
Catrine Hauerslev ◽  
Mette Balle ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Average Energy ◽  
Serum Glucose ◽  
Metabolic Effects ◽  
Moderate Amount ◽  
Insulin Dependent ◽  
Everyday Situation ◽  
Insulin Dependent Diabetic ◽  
The Impact

Alcohol accounts for 4-6% of the average energy intake in most Western countries. Alcohol-induced hypoglycaemia is a well-known and feared complication in insulin-dependent diabetic subjects, but little attention has been paid to the impact of alcohol on carbohydrate metabolism in non-insulin-dependent diabetes. The aim of the present study was to investigate in non-insulin-dependent diabetic subjects the acute metabolic effects of a moderate amount of alcohol taken with a light meal, conditions chosen to mimic an everyday situation. The patients received 500 ml non-alcoholic beer with an alcohol content (ml/l) of 0 (treatment A) and 54 (treatment B) together with a light meal, implying identity of the contents of ingredients except for alcohol. We found similar serum glucose, insulin, free fatty acid and triacylglycerol responses irrespective of addition of a modern amount of alcohol. In conclusion, a moderate amount of alcohol can be taken with a meal without eliciting hypoglycaemia in non-insulin-dependent diabetic subjects.

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