Acute toxic effects of sodium selenate on the epiphyseal plate of the rat

1971 ◽  
Vol 7 (1) ◽  
pp. 318-330 ◽  
Author(s):  
Robert D. Campo ◽  
Robert J. Bielen
Keyword(s):  
Epiphyseal Plate ◽  
Toxic Effects ◽  
Sodium Selenate ◽  
Acute Toxic

scholarly journals UJI TOKSISITAS AKUT MINUMAN PROBIOTIK SIRSAK GUNUNG (Annona montana Macf.) DENGAN METODE BSLT (Brine Shrimp Lethality Test)

2020 ◽  
Vol 1 (5) ◽  
pp. 941-948
Author(s):  
Ambar Fidyasari ◽  
Sentot Joko Raharjo ◽  
Melani Setyowati
Keyword(s):  
Acute Toxicity ◽  
Traditional Medicine ◽  
Brine Shrimp ◽  
Experimental Methods ◽  
Test Method ◽  
Toxic Effects ◽  
Brine Shrimp Lethality ◽  
Lc50 Value ◽  
A Value ◽  
Acute Toxic

Soursop fruit (Annona montana Macf.) is one of the plants can be used as as traditional medicine. This plant contains terpenoid and acetogenin which can cause toxicity. The fruit has a flavor that is tasteless so the innovation becomes probiotic drinks. This drink has been proven as an antioxidant, antibacterial, antihyperuricemia and antidiarrheal. The aim of this study was to know about acute toxicity of probiotic drink of soursop juice using brine shrimp lethality test method which will be indicated by LC50 value. This study used experimental methods conducted in the Laboratory of Farmakoknosi. There are several variations in concentration in this study, namely 10000 ppm, 20000 ppm, 30000 ppm, 40000 ppm, 50000 ppm, 60000 ppm, 70000 ppm, 80000 ppm and replication was done 3 times with total number of test animals used was 270. The results showed that probiotic drink of soursop juice can provide acute toxic effects on test animals with LC50 value of 29717,23 ppm. LC50 values ​​indicate that the mountain soursop probiotic drink is not potentially toxic because it has a value of >1000 ppm.

Acute toxic effects of a novel cyanobacterial toxin on the crustaceans Artemia salina and Daphnia pulex

1995 ◽  
Vol 133 (1) ◽  
pp. 61-69
Author(s):  
Marko Reinikainen ◽  
Jari Kiviranta ◽  
Veikko Ulvi ◽  
Marja-Leena Niku-Paavola
Keyword(s):  
Daphnia Pulex ◽  
Artemia Salina ◽  
Toxic Effects ◽  
Cyanobacterial Toxin ◽  
Acute Toxic

Acute toxic effects caused by the co-exposure of nanoparticles of ZnO and Cu in rainbow trout

2019 ◽  
Vol 687 ◽  
pp. 24-33 ◽  
Author(s):  
David Hernández-Moreno ◽  
Ana Valdehita ◽  
Estefanía Conde ◽  
Isabel Rucandio ◽  
José María Navas ◽  
...  
Keyword(s):  
Rainbow Trout ◽  
Toxic Effects ◽  
Acute Toxic

Effects of Acute and Subchronic Exposure of Topically Applied Fullerene Extracts on the Mouse Skin

1993 ◽  
Vol 9 (4) ◽  
pp. 623-630 ◽  
Author(s):  
Mark A. Nelson ◽  
Frederick E. Domann ◽  
G. Tim Bowden ◽  
Stephen B. Hooser ◽  
Quintus Fernando ◽  
...  
Keyword(s):  
Dna Synthesis ◽  
Ornithine Decarboxylase ◽  
Mouse Skin ◽  
Tumor Formation ◽  
Skin Tumor ◽  
Toxic Effects ◽  
Exposure Level ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity ◽  
Acute Toxic

The recent discovery that fullerenes (C60) can be produced in macroscopic quantities has sparked much interest in the chemistry of this unusual molecule. Concerns have also arose about the potential carcinogenic effects of this molecule. We have addressed the potential acute and subchronic toxic effects of fullerenes applied in benzene on the mouse skin. The acute toxic effects measured in this study included epidermal DNA synthesis and the induction of ornithine decarboxylase activity in the epidermis. At the topical dose of fullerenes used in these studies (i.e., 200 ug), we found no effect on either DNA synthesis or ornithine decarboxylase activity over a 72 hour time course after treatment. The subchronic effects of the fullerenes as a mouse skin tumor promoter was assessed by repeatedly applying the chemical to the skin after initiation with the polycyclic aromatic hydrocarbon, 7,12-dimethlybenz-anthracene (DMBA). Repeated administration of the fullerenes for up to 24 weeks post-initiation did not result in either benign or malignant skin tumor formation, whereas promotion with the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in the formation of benign skin tumors. Our data indicate that fullerenes applied in benzene at a likely industrial exposure level do not cause acute toxic effects on the mouse skin epidermis.

Peanut leaf extract has antioxidant and anti-inflammatory activity but no acute toxic effects

2019 ◽  
Vol 107 ◽  
pp. 104407 ◽  
Author(s):  
Jocelene Filippin Cossetin ◽  
Evelyne da Silva Brum ◽  
Rosana Casoti ◽  
Camila Camponogara ◽  
Rafaela Castro Dornelles ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Inflammatory Activity ◽  
Toxic Effects ◽  
Anti Inflammatory ◽  
Acute Toxic
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