Different effects of serotonin (5-HT) uptake blockers in caudate nucleus and hippocampus of the rabbit: Role of monoamine oxidase in dopaminergic terminals

1992 ◽  
Vol 106 (1) ◽  
pp. 118-126 ◽  
Author(s):  
A. Lupp ◽  
K. I. Bär ◽  
C. H. Lücking ◽  
T. J. Feuerstein
Keyword(s):  
Monoamine Oxidase ◽  
Caudate Nucleus ◽  
5 Ht Uptake ◽  
Uptake Blockers

scholarly journals Monoamine Oxidase Activity in the Cerebral Vasculature: Comparison between Fresh Microvessels from Different Structures and Cell Cultures Derived from Microvessels

1984 ◽  
Vol 4 (3) ◽  
pp. 415-424 ◽  
Author(s):  
R. Sercombe ◽  
F. Lasbennes ◽  
L. Drouet ◽  
A. M. Dosne ◽  
J. Seylaz
Keyword(s):  
Monoamine Oxidase ◽  
Caudate Nucleus ◽  
Cell Cultures ◽  
Regional Differences ◽  
Specific Activity ◽  
Synthetase Activity ◽  
Mao Activity ◽  
Main Factor

Monoamine oxidase (MAO) activity was studied in various preparations of porcine brain microvessels to explore further the role of this enzyme in the blood–brain barrier to catecholamines. No difference was noted ( Vm and Km) between microvessels isolated from three structures (caudate nucleus, thalamus, and cerebral cortex) in which the responses to circulating catecholamines in vivo are markedly different. Large and small microvessels from the caudate nucleus and the thalamus presented the same specific activity. Cell cultures obtained from small microvessels were rich in endothelial cells as identified by the presence of Factor VIII–related antigen. These preparations displayed an MAO activity about ninefold less than freshly isolated microvessels, although their prostaglandin synthetase activity appeared normal. These results suggest that MAO activity is not the main factor determining the regional differences in the cerebrovascular reactions to catecholamines, that MAO is not specifically localized in the endothelium but must be also present in the smooth muscle, and that the MAO activity is greatly decreased during cell culture.

ROLE OF AN ENDOGENOUS MONOAMINE OXIDASE INHIBITOR, ISATIN, IN SHRSP BRAIN

1995 ◽  
Vol 22 (s1) ◽  
pp. S86-S87 ◽  
Author(s):  
N. Hamaue ◽  
T. Endo ◽  
M. Hirafuji ◽  
N. Yamazaki ◽  
H. Togashi ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor

Serotoninergic control of prolactin secretion in prepubertal male rats

1994 ◽  
Vol 131 (5) ◽  
pp. 547-554 ◽  
Author(s):  
Enrique Aguilar ◽  
Antonio Ranchal ◽  
Manuel Tena-Sempere ◽  
Leonor Pinilla
Keyword(s):  
Specific Inhibitor ◽  
Prolactin Secretion ◽  
Male Rats ◽  
Serotoninergic System ◽  
Selective Agonist ◽  
5 Ht Uptake ◽  
Releasing Effect

Aguilar E, Ranchal A, Tena-Sempere M, Pinilla L. Serotoninergic control of prolactin secretion in prepubertal male rats. Eur J Endocrinol 1994;131:547–54. ISSN 0804–4643 The role of the serotoninergic system in the control of prolactin (PRL) secretion has been studied in prepubertal male rats. Serum PRL concentration was measured in 16-day-old male rats at different times after the administration of 5-hydroxytryptophan (5-HTP), a precursor of serotonin (5-HT) synthesis, alone or in combination with fluoxetine, a specific inhibitor of 5-HT uptake; dl-p-parachlorophenylalanine (PCPA), an inhibitor of 5-HT synthesis; and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective agonist of 5-HT1A receptors. Also, serum PRL concentration and pituitary content were measured after 5-HTP administration in castrated males implanted with silastic capsules containing testosterone or 5α-androstane-3α,17β-diol (α-diol). We found that: the reduction in serotoninergic activity after PCPA administration did not modify serum PRL concentrations; the stimulatory effect of 5-HTP on PRL secretion was not observed before day 16; the effects of 5-HTP or 5-HTP and fluoxetine were similar in intact and orchidectomized males; a significant increase in PRL secretion took place after 8-OH-DPAT administration; the duration of the stimulatory effect of 5-HTP increased after α-diol treatment; and pituitary PRL content increased after 5-HTP injection in intact males and decreased in castrated males treated with testosterone or α-diol. Therefore, we conclude that: the PRL-releasing effect of 5-HTP remains after orchidectomy; activation of 5-HT1A receptors may mediate, at least partially, the effect of 5-HTP; testosterone and α-diol affect the duration of PRL release after 5-HTP administration differently; and testicular factors other than androgens might be involved in the effects of 5-HTP on PRL pituitary accumulation. Enrique Aguilar, Department of Physiology, Faculty of Medicine, Córdoba University, 14004 Córdoba, Spain

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