Clinical significance of removal of tumor thrombi in the main portal vein in patients with hepatocellular carcinoma

1995 ◽  
Vol 2 (3) ◽  
pp. 266-272 ◽  
Author(s):  
Ming-Hui Mei ◽  
Jian-Hua Tang ◽  
Qian Chen ◽  
Xian-Lan Zhang ◽  
Jing-Hong Yang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Portal Vein ◽  
Clinical Significance ◽  
Main Portal Vein ◽  
Tumor Thrombi

Liver resection for hepatocellular carcinoma (HCC) with direct removal of tumor thrombi in the main portal vein

1992 ◽  
Vol 16 (6) ◽  
pp. 1172-1176 ◽  
Author(s):  
Yoshio Yamaoka ◽  
Kaoru Kumada ◽  
Keiichi Ino ◽  
Takashi Takayasu ◽  
Yasuyuki Shimahara ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Portal Vein ◽  
Main Portal Vein ◽  
Tumor Thrombi

Transcatherter therapy for hepatocellular carcinoma with tumor thrombi in the main branch of the portal vein or inferior vena cava.

Kanzo ◽  
1992 ◽  
Vol 33 (7) ◽  
pp. 531-540 ◽  
Author(s):  
Keiji TAICADA ◽  
Kenji NAKAMURA ◽  
Takao MANABE ◽  
Noriaki USUKI ◽  
Toshio KAMINOU ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Inferior Vena Cava ◽  
Portal Vein ◽  
Inferior Vena ◽  
Vena Cava ◽  
Tumor Thrombi

scholarly journals A Critical Role for ZDHHC2 in Metastasis and Recurrence in Human Hepatocellular Carcinoma

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Chuanhui Peng ◽  
Zhijun Zhang ◽  
Jian Wu ◽  
Zhen Lv ◽  
Jie Tang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Portal Vein ◽  
Tumor Size ◽  
Chromosomal Region ◽  
Critical Role ◽  
Migration And Invasion ◽  
Metastatic Recurrence ◽  
Tumor Thrombi

It has been demonstrated that loss of heterozygosity (LOH) was frequently observed on chromosomes 8p22-p23 in hepatocellular carcinoma (HCC) and was associated with metastasis and prognosis of HCC. However, putative genes functioning on this chromosomal region remain unknown. In this study, we evaluated LOH status of four genes on 8p22-p23 (MCPH1, TUSC3, KIAA1456, and ZDHHC2). LOH on ZDHHC2 was associated with early metastatic recurrence of HCC following liver transplantation and was correlated with tumor size and portal vein tumor thrombi. Furthermore, our results indicate that ZDHHC2 expression was frequently decreased in HCC. Overexpression of ZDHHC2 could inhibit proliferation, migration, and invasion of HCC cell line Bel-7402in vitro. These results suggest an important role for ZDHHC2 as a tumor suppressor in metastasis and recurrence of HCC.

Hepatic Resection for Hepatocellular Carcinoma with Tumor Thrombus in the Major Portal Vein

2015 ◽  
Vol 32 (6) ◽  
pp. 413-420 ◽  
Author(s):  
Hidenobu Kojima ◽  
Etsuro Hatano ◽  
Kojiro Taura ◽  
Satoru Seo ◽  
Kentaro Yasuchika ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Portal Vein ◽  
Hepatic Resection ◽  
Tumor Thrombus ◽  
Disease Free Survival ◽  
Hepatic Arterial Infusion ◽  
Hazard Ratio ◽  
Infusion Chemotherapy ◽  
Independent Risk Factors ◽  
Tumor Thrombi

Background: The prognosis of hepatocellular carcinoma (HCC) with tumor thrombus in the major portal vein has been extremely poor. We investigated the outcome of hepatic resection in HCC with major portal vein tumor thrombus (PVTT). Methods: We retrospectively evaluated 52 consecutive patients who underwent hepatic resection for HCC with tumor thrombi in the first branch or trunk of the portal vein. Factors related to disease-free survival (DFS) and overall survival (OS) were analyzed. Results: The median DFS and OS times were 8.9 and 27.6 months for the whole cohort, respectively. Multiple tumors (hazard ratio 2.12; 95% CI 1.11-4.33; p = 0.023), positive surgical margins (hazard ratio 2.45; 95% CI 1.19-4.81; p = 0.016), and non-adjuvant hepatic arterial infusion chemotherapy (HAIC; hazard ratio 2.07; 95% CI 1.11-3.90; p = 0.023) were independent risk factors for DFS. Non-adjuvant HAIC (hazard ratio 1.84; 95% CI 1.01-3.37; p = 0.047) was an independent risk factor for OS. Conclusions: Macroscopically curative resection seems to be of benefit to HCC patients with PVTT, even with tumor thrombi in the first branch or trunk of the portal vein. Adjuvant postoperative HAIC might improve DFS and OS in such patients.

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